Water diffusion in rat brain in vivo as detected at very large b values is multicompartmental

Pfeuffer, Josef

doi:10.1016/s1352-8661(99)00013-7

Cited by 70 publications

(124 citation statements)

References 47 publications

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“…The range of diffusion coefficients in vivo may approach a continuum and not reflect only two components (Pfeuffer, et al 1999). The exact origins of the diffusion components continue to remain a topic of debate.…”

Section: Discussionmentioning

confidence: 99%

Cognitive functions correlate with white matter architecture in a normal pediatric population: A diffusion tensor MRI study

Schmithorst¹,

Wilke²,

Dardzinski³

et al. 2005

Human Brain Mapping

364

233

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A possible relationship between cognitive abilities and white matter structure as assessed by magnetic resonance diffusion tensor imaging (DTI) was investigated in the pediatric population. DTI was performed on 47 normal children ages 5–18. Using a voxelwise analysis technique, the fractional anisotropy (FA) and mean diffusivity (MD) were tested for significant correlations with Wechsler full‐scale IQ scores, with subject age and gender used as covariates. Regions displaying significant positive correlations of IQ scores with FA were found bilaterally in white matter association areas, including frontal and occipito‐parietal areas. No regions were found exhibiting correlations of IQ with MD except for one frontal area significantly overlapping a region containing a significant correlation with FA. The positive direction of the correlation with FA is the same as that found previously with age, and indicates a positive relationship between fiber organization and/or density with cognitive function. The results are consistent with the hypothesis that regionally specific increased fiber organization is a mechanism responsible for the normal development of white matter tracts. Hum Brain Mapp, 2005. © 2005 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Cognitive functions correlate with white matter architecture in a normal pediatric population: A diffusion tensor MRI study

Schmithorst¹,

Wilke²,

Dardzinski³

et al. 2005

Human Brain Mapping

364

233

View full text Add to dashboard Cite

show abstract

“…45 The non-monoexponential signal attenuation of the diffusion curves has subsequently been confirmed in other neural fibres such as the rat sciatic nerve, 80 bovine optic nerve, 57,60,61 frog sciatic nerve, 58 rat spinal cord white matter, 62,81 and human brain white matter. [82][83][84][85] The degree of curvature and the signal amplitude at which the curves level off are typically greater for neural fibres than for grey matter in the rat brain [86][87][88][89] or human brain.…”

Section: Mgmentioning

confidence: 99%

The basis of anisotropic water diffusion in the nervous system – a technical review

2002

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Anisotropic water diffusion in neural fibres such as nerve, white matter in spinal cord, or white matter in brain forms the basis for the utilization of diffusion tensor imaging (DTI) to track fibre pathways. The fact that water diffusion is sensitive to the underlying tissue microstructure provides a unique method of assessing the orientation and integrity of these neural fibres, which may be useful in assessing a number of neurological disorders. The purpose of this review is to characterize the relationship of nuclear magnetic resonance measurements of water diffusion and its anisotropy (i.e. directional dependence) with the underlying microstructure of neural fibres. The emphasis of the review will be on model neurological systems both in vitro and in vivo. A systematic discussion of the possible sources of anisotropy and their evaluation will be presented followed by an overview of various studies of restricted diffusion and compartmentation as they relate to anisotropy. Pertinent pathological models, developmental studies and theoretical analyses provide further insight into the basis of anisotropic diffusion and its potential utility in the nervous system.

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“…72 ) did then, however, demonstrate a clear diffusion time dependence over the same range of diffusion times as in Niendorf et al 97 At this range of b-values the data could only be modeled successfully using a three component exponential fit. 99 In the most recent data, here obtained under in vivo conditions from a rat brain 100 with b-values up to 7 Â 10 4 s mm À2 a continuous distribution of diffusion coefficients is allowed, which however are resolvable into three main peaks. It should be noted that these three peaks are not the same as the three components of the triexponential fit described in Assaf et al 99 The model developed by Stanisz et al 69 and described above was primarily developed to account for the data obtained from excised bovine optic nerve.…”

Section: 78mentioning

confidence: 99%

The effects of microscopic tissue parameters on the diffusion weighted magnetic resonance imaging experiment

2001

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This review examines the way in which microscopic tissue parameters can affect MR experiments which are sensitive to diffusion. The interaction between the intra-and extravascular as well as that between the intraand extracellular spaces is examined. Susceptibility gradients due to the presence of deoxyhemoglobin can cause diffusion-induced signal losses which are significant in functional magnetic resonance experiments, particularly at higher main magnetic field strengths. This is also true of the fast response that manifests itself as an early negative signal change in functional magnetic resonance experiments. The fields surrounding paramagnetic vessels are described and the way in which diffusion in these fields contributes to functional signal changes is examined. Flow in the capillary bed can be a confounding factor in experiments which aim to examine the diffusion characteristics of extravascular water. It is potentially also a method for assessing capillary perfusion. The intravoxel incoherent motion experiment is described in terms of how significantly this effect can influence diffusion attenuation curves from water. The major models for describing water diffusion in tissue are presented, as are the main experimental results that have contributed to an understanding of the mechanisms of diffusion contrast. The widely accepted view that changes in the diffusion characteristics are caused by a shift of water to the intracellular space and a concomitant change in extracellular tortuosity is examined critically. More recent experiments that indicate that a reduction in the intracellular diffusion may occur simultaneously with the cell swelling are described and their compatibility with existing models discussed.

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Water diffusion in rat brain in vivo as detected at very large b values is multicompartmental

Cited by 70 publications

References 47 publications

Cognitive functions correlate with white matter architecture in a normal pediatric population: A diffusion tensor MRI study

Cognitive functions correlate with white matter architecture in a normal pediatric population: A diffusion tensor MRI study

The basis of anisotropic water diffusion in the nervous system – a technical review

The effects of microscopic tissue parameters on the diffusion weighted magnetic resonance imaging experiment

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