Water-Content Electrical Property Tomography (wEPT) for Mapping Brain Tissue Conductivity in the 200–1000 kHz Range: Results of an Animal Study

Wenger, Cornelia; Hershkovich, Hadas Sara; Tempel-Brami, Catherine; Giladi, Moshe; Bomzon, Zéev

doi:10.1007/978-3-030-21293-3_20

Cited by 8 publications

(6 citation statements)

References 43 publications

(52 reference statements)

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“…One possible approach that might help to improve the accuracy of the results consists in using a technique named water-content based electrical properties tomography (wEPT), as discussed by Wenger et al ( 2019 ). The basis of this technique is that tissue electric conductivity is highly correlated with its water content and by estimating the latter it is possible to predict the former.…”

Section: Discussionmentioning

confidence: 99%

Temperature and Impedance Variations During Tumor Treating Fields (TTFields) Treatment

Gentilal

Abend²,

Naveh³

et al. 2022

Front. Hum. Neurosci.

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Tumor Treating Fields (TTFields) is an FDA-approved cancer treatment technique used for glioblastoma multiforme (GBM). It consists in the application of alternating (100–500 kHz) and low-intensity (1–3 V/cm) electric fields (EFs) to interfere with the mitotic process of tumoral cells. In patients, these fields are applied via transducer arrays strategically positioned on the scalp using the NovoTAL™ system. It is recommended that the patient stays under the application of these fields for as long as possible. Inevitably, the temperature of the scalp increases because of the Joule effect, and it will remain above basal values for most part of the day. Furthermore, it is also known that the impedance of the head changes throughout treatment and that it might also play a role in the temperature variations. The goals of this work were to investigate how to realistically account for these increases and to quantify their impact in the choice of optimal arrays positions using a realistic head model with arrays positions obtained through NovoTAL™. We also studied the impedance variations based on the log files of patients who participated in the EF-14 clinical trial. Our computational results indicated that the layouts in which the arrays were very close to each other led to the appearance of a temperature hotspot that limited how much current could be injected which could consequently reduce treatment efficacy. Based on these data, we suggest that the arrays should be placed at least 1 cm apart from each other. The analysis of the impedance showed that the variations seen during treatment could be explained by three main factors: slow and long-term variations, array placement, and circadian rhythm. Our work indicates that both the temperature and impedance variations should be accounted for to improve the accuracy of computational results when investigating TTFields.

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Section: Discussionmentioning

confidence: 99%

Temperature and Impedance Variations During Tumor Treating Fields (TTFields) Treatment

Gentilal

Abend²,

Naveh³

et al. 2022

Front. Hum. Neurosci.

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“…In addition to MRI based techniques, water‐content electrical property tomography has also been used for mapping brain tissue conductivities in the intermediate frequency range 200–1000 kHz. [ 156 ] GM and WM surface meshes (most typically using anisotropic conductivity tensors [ 157 ] ) are created in software's like the SimNibs pipeline while other tissue meshes can be modelled using the Brainsuite package. Mimics are an additional software package used to create virtual tumors and to correct bumps or holes in the total mesh.…”

Section: Tumour‐treating Fieldsmentioning

confidence: 99%

Electrotherapies for Glioblastoma

et al. 2021

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Non-thermal, intermediate frequency (100-500 kHz) electrotherapies present a unique therapeutic strategy to treat malignant neoplasms. Here, pulsed electric fields (PEFs) which induce reversible or irreversible electroporation (IRE) and tumour-treating fields (TTFs) are reviewed highlighting the foundations, advances, and considerations of each method when applied to glioblastoma (GBM). Several biological aspects of GBM that contribute to treatment complexity (heterogeneity, recurrence, resistance, and blood-brain barrier(BBB)) and electrophysiological traits which are suggested to promote glioma progression are described. Particularly, the biological responses at the cellular and molecular level to specific parameters of the electrical stimuli are discussed offering ways to compare these parameters despite the lack of a universally adopted physical description. Reviewing the literature, a disconnect is found between electrotherapy techniques and how they target the biological complexities of GBM that make treatment difficult in the first place. An attempt is made to bridge the interdisciplinary gap by mapping biological characteristics to different methods of electrotherapy, suggesting important future research topics and directions in both understanding and treating GBM. To the authors' knowledge, this is the first paper that attempts an in-tandem assessment of the biological effects of different aspects of intermediate frequency electrotherapy methods, thus offering possible strategies toward GBM treatment.

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“…In order to properly perform numerical simulations of TTFields delivery, it is necessary to create accurate computational models that are patient-specific [11,12,[24][25][26]. This involves creating a 3D volume representing the patient, in which dielectric properties (primarily conductivity) are assigned to each voxel.…”

Section: Patient-specific Model Creationmentioning

confidence: 99%

Tumor-Treating Fields at EMBC 2019: A Roadmap to Developing a Framework for TTFields Dosimetry and Treatment Planning

Bomzon¹,

Wenger²,

Proescholdt

et al. 2020

Brain and Human Body Modeling 2020

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Tumor Treating Fields (TTFields) are electric fields known to exert an anti-mitotic effect on cancerous tumors. TTFields have been approved for the treatment of glioblastoma and malignant pleural mesothelioma. Recent studies have shown a correlation between TTFields doses delivered to the tumor bed and patient survival. These findings suggest that patient outcome could be significantly improved with rigorous treatment planning, in which numerical simulations are used to plan treatment in order to optimize delivery of TTFields to the tumor bed.Performing such adaptive planning in a practical and meaningful manner requires a rigorous and scientifically proven framework defining TTFields dose and showing how dose distribution influences disease progression in different malignancies (TTFields dosimetry). At EMBC 2019, several talks discussing key components related to TTFields dosimetry and treatment planning were presented. Here we provide a short overview of this work and discuss how it sets the foundations for the emerging field of TTFields dosimetry and treatment planning.

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Water-Content Electrical Property Tomography (wEPT) for Mapping Brain Tissue Conductivity in the 200–1000 kHz Range: Results of an Animal Study

Cited by 8 publications

References 43 publications

Temperature and Impedance Variations During Tumor Treating Fields (TTFields) Treatment

Temperature and Impedance Variations During Tumor Treating Fields (TTFields) Treatment

Electrotherapies for Glioblastoma

Tumor-Treating Fields at EMBC 2019: A Roadmap to Developing a Framework for TTFields Dosimetry and Treatment Planning

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