Water composed of reduced hydrogen bonds activated by localized surface plasmon resonance effectively enhances anti-viral and anti-oxidative activities of melatonin

Renn, Ting Yi; Yang, Chih Ping; Wu, Un‐In; Chen, Li You; Der, Fu; Tikhonova, Maria A.; Amstislavskaya, Tamara G.; Liao, Wen Chieh; Lin, Che Tong; Liu, Yu Chuan; Chang, Hong-Yeh

doi:10.1016/j.cej.2021.131626

Cited by 7 publications

(5 citation statements)

References 42 publications

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“…Additionally, although melatonin does not possess direct antiviral capacity, supplemental melatonin has shown favorable effects, eliminating the pathogenicity of highly deadly viruses [461][462][463][464][465]. This has been extensively documented in various case reports, with the prevention of hemorrhagic shock syndrome from Ebola virus infection being particularly promising [466].…”

Section: Post-stroke Melatonin Treatmentmentioning

confidence: 99%

Non-Excitatory Amino Acids, Melatonin, and Free Radicals: Examining the Role in Stroke and Aging

Carretero,

Ramos,

Segura-Chama

et al. 2023

Antioxidants

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The aim of this review is to explore the relationship between melatonin, free radicals, and non-excitatory amino acids, and their role in stroke and aging. Melatonin has garnered significant attention in recent years due to its diverse physiological functions and potential therapeutic benefits by reducing oxidative stress, inflammation, and apoptosis. Melatonin has been found to mitigate ischemic brain damage caused by stroke. By scavenging free radicals and reducing oxidative damage, melatonin may help slow down the aging process and protect against age-related cognitive decline. Additionally, non-excitatory amino acids have been shown to possess neuroprotective properties, including antioxidant and anti-inflammatory in stroke and aging-related conditions. They can attenuate oxidative stress, modulate calcium homeostasis, and inhibit apoptosis, thereby safeguarding neurons against damage induced by stroke and aging processes. The intracellular accumulation of certain non-excitatory amino acids could promote harmful effects during hypoxia-ischemia episodes and thus, the blockade of the amino acid transporters involved in the process could be an alternative therapeutic strategy to reduce ischemic damage. On the other hand, the accumulation of free radicals, specifically mitochondrial reactive oxygen and nitrogen species, accelerates cellular senescence and contributes to age-related decline. Recent research suggests a complex interplay between melatonin, free radicals, and non-excitatory amino acids in stroke and aging. The neuroprotective actions of melatonin and non-excitatory amino acids converge on multiple pathways, including the regulation of calcium homeostasis, modulation of apoptosis, and reduction of inflammation. These mechanisms collectively contribute to the preservation of neuronal integrity and functions, making them promising targets for therapeutic interventions in stroke and age-related disorders.

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Section: Post-stroke Melatonin Treatmentmentioning

confidence: 99%

Non-Excitatory Amino Acids, Melatonin, and Free Radicals: Examining the Role in Stroke and Aging

Carretero,

Ramos,

Segura-Chama

et al. 2023

Antioxidants

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“…Essentially, the elevated interactions with other molecules via increased free water molecules in PAW enhance the intrinsic activities of these molecules. Melatonin is known to dissolve poorly in water [ 249 ]; however, melatonin is able to form stronger hydrogen bonds in PAW resulting in enhancement of solubility between ~120% [ 248 ] to ~150% [ 250 ].…”

Section: Light Water and Melatonin: Ancient Synergies In A Modern Worldmentioning

confidence: 99%

“…Melatonin prepared in PAW compared to bulk deionized water exhibited enhanced clearance of hydroxyl radical at 11.9% vs. 6.69%, respectively; its antiviral potency against dengue virus in infected human hepatocarcinoma cells is also enhanced, reducing infectivity by 14.7% vs. 20.6% in bulk [ 250 ]. Male Wistar rats subjected to chronic sleep deprivation (CSD) using the disc-on-water methodology [ 254 ] and treated with 10 mg/kg melatonin via intraperitoneal (IP) injection dissolved in PAW exhibited significantly better results in all parameters detected, including hepatic function and metabolic activity, than control (no treatment), CSD only, and CSD + melatonin dissolved in bulk deionized water groups [ 250 ]. It is plausible that when melatonin is dissolved in PAW, the intrinsic anti-inflammatory properties of PAW may also be responsible for molecular mechanisms that support/enhance melatonin’s antiviral and antioxidative features.…”

Section: Light Water and Melatonin: Ancient Synergies In A Modern Worldmentioning

confidence: 99%

“…However, the addition of only one water molecule that provides an H-bonding relay pathway significantly lowered the energy barrier in the tautomerization step to enhance the scavenging potential by melatonin [ 271 ]. The fact that melatonin prepared in PAW exhibit 78% increased effectiveness in • OH scavenging compared to bulk (11.9% vs. 6.69%) [ 250 ] implies that melatonin may adopt more favorable conformations that enhance its intrinsic activities as a result of stronger H-bonds formed in water with reduced viscosity and H-bonds compared to bulk.…”

Section: Light Water and Melatonin: Ancient Synergies In A Modern Worldmentioning

confidence: 99%

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Light, Water, and Melatonin: The Synergistic Regulation of Phase Separation in Dementia

Loh¹,

Reíter

2023

IJMS

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The swift rise in acceptance of molecular principles defining phase separation by a broad array of scientific disciplines is shadowed by increasing discoveries linking phase separation to pathological aggregations associated with numerous neurodegenerative disorders, including Alzheimer’s disease, that contribute to dementia. Phase separation is powered by multivalent macromolecular interactions. Importantly, the release of water molecules from protein hydration shells into bulk creates entropic gains that promote phase separation and the subsequent generation of insoluble cytotoxic aggregates that drive healthy brain cells into diseased states. Higher viscosity in interfacial waters and limited hydration in interiors of biomolecular condensates facilitate phase separation. Light, water, and melatonin constitute an ancient synergy that ensures adequate protein hydration to prevent aberrant phase separation. The 670 nm visible red wavelength found in sunlight and employed in photobiomodulation reduces interfacial and mitochondrial matrix viscosity to enhance ATP production via increasing ATP synthase motor efficiency. Melatonin is a potent antioxidant that lowers viscosity to increase ATP by scavenging excess reactive oxygen species and free radicals. Reduced viscosity by light and melatonin elevates the availability of free water molecules that allow melatonin to adopt favorable conformations that enhance intrinsic features, including binding interactions with adenosine that reinforces the adenosine moiety effect of ATP responsible for preventing water removal that causes hydrophobic collapse and aggregation in phase separation. Precise recalibration of interspecies melatonin dosages that account for differences in metabolic rates and bioavailability will ensure the efficacious reinstatement of the once-powerful ancient synergy between light, water, and melatonin in a modern world.

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“…29 The resulting electron-doping PAW with reduced HBs demonstrated many distinct properties, which significantly differed from those of untreated bulk water. 29,30 The potential for innovative applications of PAW in chemistry, 31,32 physics 33,34 and medicine 35,36 was previously intensively investigated. However, there are always issues of concern with catalyzed hydrogen evolution reactions (HERs) 37 and oxygen evolution reactions (OERs) 38 utilizing PAW with a trace of Au of ca .…”

Section: Introductionmentioning

confidence: 99%

Preparation of pure active water for auto-catalytic reactions performed in it

Yang

Mai

et al. 2023

Nanoscale

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Water composed of reduced hydrogen bonds activated by localized surface plasmon resonance effectively enhances anti-viral and anti-oxidative activities of melatonin

Cited by 7 publications

References 42 publications

Non-Excitatory Amino Acids, Melatonin, and Free Radicals: Examining the Role in Stroke and Aging

Non-Excitatory Amino Acids, Melatonin, and Free Radicals: Examining the Role in Stroke and Aging

Light, Water, and Melatonin: The Synergistic Regulation of Phase Separation in Dementia

Preparation of pure active water for auto-catalytic reactions performed in it

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