Water-compatible surface-imprinted microspheres for high adsorption and selective recognition of peptide drug from aqueous media

Du, Chunbao; Hu, Xiaoling; Guan, Ping; Guo, Longxia; Qian, Liwei; Song, Renyuan; Li, Ji; Wang, Chaoli

doi:10.1039/c4tb02030h

Cited by 34 publications

(15 citation statements)

References 48 publications

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“…Thus, electrostatic interactions play a leading role in the adsorption of the template in NIPs. Using [Bvim][Phe] as an ion‐pair dummy template for preparing MIPs, the charged imidazolium was located inside the imprinted cavities, which would be lead to multiple interactions with l‐ Phe . Hence, salt concentration marginally affects adsorption.…”

Section: Resultsmentioning

confidence: 99%

Preparation of l‐phenylalanine‐imprinted solid‐phase extraction sorbent by Pickering emulsion polymerization and the selective enrichment of l‐phenylalanine from human urine

Guan

et al. 2016

J of Separation Science

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A novel l-phenylalanine molecularly imprinted solid-phase extraction sorbent was synthesized by the combination of Pickering emulsion polymerization and ion-pair dummy template imprinting. Compared to other polymerization methods, the molecularly imprinted polymers thus prepared exhibit a high specific surface, large pore diameter, and appropriate particle size. The key parameters for solid-phase extraction were optimized, and the result indicated that the molecularly imprinted polymer thus prepared exhibits a good recovery of 98.9% for l-phenylalanine. Under the optimized conditions of the procedure, an analytical method for l-phenylalanine was well established. By comparing the performance of the molecularly imprinted polymer and a commercial reverse-phase silica gel, the obtained molecularly imprinted polymer as an solid-phase extraction sorbent is more suitable, exhibiting high precision (relative standard deviation 3.2%, n = 4) and a low limit of detection (60.0 ± 1.9 nmol·L(-1) ) for the isolation of l-phenylalanine. Based on these results, the combination of the Pickering emulsion polymerization and ion-pair dummy template imprinting is effective for preparing selective solid-phase extraction sorbents for the separation of amino acids and organic acids from complex biological samples.

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Section: Resultsmentioning

confidence: 99%

Preparation of l‐phenylalanine‐imprinted solid‐phase extraction sorbent by Pickering emulsion polymerization and the selective enrichment of l‐phenylalanine from human urine

Guan

et al. 2016

J of Separation Science

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“…However, multiple interactions commonly exist due to the diversity of biomacromolecules and carriers, including ion-ion electrostatic interactions (20-80 kcal mol À1 ), coordination bonding (20-50 kcal mol À1 ), hydrogen bonding (1-30 kcal mol À1 ), p-p stacking (0-12 kcal mol À1 ), and van der Waals interactions. 30,46 Combined with the above analysis, it could be conrmed that the adsorption of SiO 2 @IL was driven by the synergistic interactions of electrostatic interaction, hydrogen bonding and p-p stacking. The differences between these non-covalent interactions were the probability and binding strength, which obey the Boltzmann distribution.…”

Section: Effect Of Ph On Immobilization Capacitymentioning

confidence: 88%

“…This binding energy of Cl 2p 3/2 showed that it was solely associated with Cl À which was in good agreement with the reference. 30 According to analysis of the XPS results, it was conrmed that the ionic liquid functionalization of SiO 2 @IL had been carried out successfully.…”

Section: Ionic Liquid Functionalization Of Sio 2 Nanoparticlesmentioning

confidence: 99%

Non-covalent loading of ionic liquid-functionalized nanoparticles for bovine serum albumin: experiments and theoretical analysis

Jia

Wang

et al. 2019

RSC Adv.

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“…Microspheres have diverse merits including wide distribution of particle size ranging from several nano‐ to micro‐meters, changeable appearances of solid‐, hollow‐, dumbbell‐, and onion‐like structures, good dispersibility in different solvents, facile preparation approaches, and so on. Depending on the different characters of selected substrates, organic as well as inorganic microspheres both have potentials to allow an imprinting shell generated on their external surface …”

Section: The Currently Popular Imprinting Materialsmentioning

confidence: 99%

Molecularly Imprinted Materials for Selective Biological Recognition

Zhang

et al. 2019

Macromol. Rapid Commun.

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Molecular imprinting is an approach of generating imprinting cavities in polymer structures that are compatible with the target molecules. The cavities have memory for shape and chemical recognition, similar to the recognition mechanism of antigen–antibody in organisms. Their structures are also called biomimetic receptors or synthetic receptors. Owing to the excellent selectivity and unique structural predictability of molecularly imprinted materials (MIMs), practical MIMs have become a rapidly evolving research area providing key factors for understanding separation, recognition, and regenerative properties toward biological small molecules to biomacromolecules, even cell and microorganism. In this review, the characteristics, morphologies, and applicability of currently popular carrier materials for molecular imprinting, especially the fundamental role of hydrogels, porous materials, hierarchical nanoparticles, and 2D materials in the separation and recognition of biological templates are discussed. Moreover, through a series of case studies, emphasis is given on introducing imprinting strategies for biological templates with different molecular scales. In particular, the differences and connections between small molecular imprinting (bulk imprinting, “dummy” template imprinting, etc.), large molecular imprinting (surface imprinting, interfacial imprinting, etc.), and cell imprinting strategies are demonstrated in detail. Finally, future research directions are provided.

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Water-compatible surface-imprinted microspheres for high adsorption and selective recognition of peptide drug from aqueous media

Abstract: Through employing a synergetic effect of directional and non-directional interactions, surface-imprinted microspheres can selectively recognize thymopentin in aqueous media.

Cited by 34 publications

References 48 publications

Preparation of l‐phenylalanine‐imprinted solid‐phase extraction sorbent by Pickering emulsion polymerization and the selective enrichment of l‐phenylalanine from human urine

Preparation of l‐phenylalanine‐imprinted solid‐phase extraction sorbent by Pickering emulsion polymerization and the selective enrichment of l‐phenylalanine from human urine

Non-covalent loading of ionic liquid-functionalized nanoparticles for bovine serum albumin: experiments and theoretical analysis

Molecularly Imprinted Materials for Selective Biological Recognition

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