Water behavior study for tailoring fructose-citric acid based natural deep eutectic solvent properties towards antibiotics solubilization

Lorenzetti, Anabela S.; Fiego, Marcos J. Lo; Silva, María Fernanda; Domini, Claudia E.; Gomez, Federico José Vicente

doi:10.1016/j.molliq.2022.119917

Cited by 15 publications

(8 citation statements)

References 34 publications

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“…They measured the density, viscosity, surface tension, and refractive index of neat DES. Lorenzetti et al 20 measured the conductivity, viscosity, density, refractive index, and contact angle of the DES of a (citric acid + fructose) + water mixture. Also, they investigated the water content of DES on ciprofloxacin solubility.…”

Section: ■ Introductionmentioning

confidence: 99%

Density, Viscosity, and Refractive Index of a Choline Chloride + d-(−)-Fructose Deep Eutectic Solvent + Water Mixture at Different Temperatures: An Experimental Study and Thermodynamic Modeling

Seyf

Zarei

2022

J. Chem. Eng. Data

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In the present study, first, the deep eutectic solvent (DES) of choline chloride + D-(−)-fructose was prepared using the heating method. Then, its physical properties including density, viscosity, and refractive index were experimentally measured at temperatures in the range of 283.15−343.15 K and a full composition range of DES at atmospheric pressure (83.09 kPa). The values of these three properties decrease with an increase in temperature, while the mole fraction has a nonlinear effect on these properties. For the density and refractive index, an increase in the mole fraction of DES to 0.3 causes a sharp increase in these physical properties, while from 0.3 to 1, this increase occurs slowly. For viscosity, increasing the mole fraction of DES has little effect at first, but at high mole fractions of DES, a sharp increase in viscosity occurs. In addition, the sharp change in the viscosity of DES depends on the temperature so that at low temperatures, this phenomenon occurs faster. So, adding water to DES will tailor the viscosity of the mixture to facilitate its applications. A polynomial equation was used to describe the density and refractive index as a function of temperature and mole fraction. Experimental viscosity was fitted to the Vogel−Tammann−Fulcher (VTF) equation. Using the measured data, in sequence, the values of excess molar volume (V m Ex ), viscosity deviation (Δη), and refractive index deviation (Δn D ) were calculated. The Redlich−Kister polynomial equation, finally, was used to correlate the values of V m Ex , Δη, and Δn D .

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Section: ■ Introductionmentioning

confidence: 99%

Density, Viscosity, and Refractive Index of a Choline Chloride + d-(−)-Fructose Deep Eutectic Solvent + Water Mixture at Different Temperatures: An Experimental Study and Thermodynamic Modeling

Seyf

Zarei

2022

J. Chem. Eng. Data

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“…[88] The results present in the compound buffer are less discrepant among themselves, thus, the mixed nature of the buffered system favored the quantification of ions by presenting greater precision between the results. This behavior can be explained by the presence of citric acid in the medium, enabling strong intermolecular interactions, [89,90] such as hydrogen bonds, which may have improved the stability of the colloidal system. [80]…”

Section: Quantification Stagementioning

confidence: 99%

Bottom‐Up Synthesis Optimization Through The Design Of Experiments Using Blue N,S‐Carbon Dots With Interesting Affinity For Potentially Toxic Elements

Silva de Araújo,

Costa Ferrer,

Seagesser Santos

et al. 2023

ChemistrySelect

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Water contamination by heavy metals is a global issue for environmental safety and new technologies have been developed aim to evaluate the contamination, mainly by anthropogenic action. In this work, we synthesized blue light‐emitting carbon dots (CDs) from ionic sources for sensing applications of heavy metal cations in an aqueous solution. Spectroscopic and morphologic characteristics of the CDs were performed using Fourier transform infrared (FTIR) spectroscopy, fluorescence, and absorption techniques, besides transmission electron microscopy (TEM), dynamic light scattering (DLS), and zeta potential (ZP) measurements. Moreover, a two‐level full factorial design of experiments (DOE) was carried out to achieve the best hydrothermal parameters of synthesis, including the number of mols of precursors, temperature, and reaction time. The pH and buffer nature were evaluated for the quantification step to improve the N,S‐CDs response. We have obtained a range of 2.23–8.57 μmol L−1 (among Bi3+, Cd2+, Hg22+, Hg2+, Pb2+, and Sb3+) in terms of limit of detection (LOD). These aspects frame the material as a potential sensor for the identification of heavy metals in water.

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“…9,14,[30][31][32][33] In addition, and albeit not targeting biosensing applications, a few groups have recently reported the possibility to synthetize beads mixing the alginate solution with deep eutectic solvents (DES). 19,[34][35][36] These DES (mixtures of two or more pure compounds for which the eutectic temperature is below that of the ideal liquid mixture) [37][38][39] can not only be made with natural molecules (acids, sugars, alcohols, etc.) but can also open the door to unique modifications (polarity, vapor pressure, viscosity, etc.)…”

Section: Introductionmentioning

confidence: 99%

Lab-on-a-Bead: Polymeric Natural Deep Eutectic Solvents as a Versatile Platform for (Bio)sensor Design

Gomez

Vidal

Zanini

et al. 2023

Preprint

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Natural polymers offer not only low-cost, wide availability, biocompatibility, and biodegradability but also a rich chemical functionality towards custom modifications and new applications. Among those, sodium alginate (ALG) offers a number of competitive advantages, including the possibility to form beads by a simple process call spherification as well as their modification by a wide number of processes, including the possibility to mixing the alginate solution with deep eutectic solvents (DES). Thus, and considering the capacity of DES to stabilize enzymes, the main objective of this work was to design and fabricate a new PODES (using ALG as one of the components, ALGPODES) and to deploy this material as a new phase to develop colorimetric biosensors. The formed beads displayed a narrow size distribution (2.9 0.1 mm) and a permeable structure with large internal cavities (25-100 m). The applicability of these beads towards analytical applications (lab-on-a-bead) was demonstrated by integrating three sensing platforms and by their application in real food samples.

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Water behavior study for tailoring fructose-citric acid based natural deep eutectic solvent properties towards antibiotics solubilization

Cited by 15 publications

References 34 publications

Density, Viscosity, and Refractive Index of a Choline Chloride + d-(−)-Fructose Deep Eutectic Solvent + Water Mixture at Different Temperatures: An Experimental Study and Thermodynamic Modeling

Density, Viscosity, and Refractive Index of a Choline Chloride + d-(−)-Fructose Deep Eutectic Solvent + Water Mixture at Different Temperatures: An Experimental Study and Thermodynamic Modeling

Bottom‐Up Synthesis Optimization Through The Design Of Experiments Using Blue N,S‐Carbon Dots With Interesting Affinity For Potentially Toxic Elements

Lab-on-a-Bead: Polymeric Natural Deep Eutectic Solvents as a Versatile Platform for (Bio)sensor Design

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