Water-based synthesis and processing of novel biodegradable elastomers for medical applications

Hsu, Shan‐hui; Hung, Kun‐Che; Lin, Yi-Cheng; Su, Chi‐Cheung; Yeh, Hsi-Yi; Jeng, U‐Ser; Lu, Chun‐Yi; Dai, Shenghong A.; Fu, Wei‐En; Lin, Jinru

doi:10.1039/c4tb00572d

Cited by 82 publications

(68 citation statements)

References 52 publications

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“…Waterborne PU was a dispersion of compact NPs, each consisting of hundreds of polymer chains. 27 We speculated that the elasticity 25 and low Tg of PU chain segment may allow SPIO NPs to be embedded into PU NPs under ultrasonic high frequency and temperature operation (close to 60°C). Because PU NPs accommodated foreign SPIO NPs (~10 nm), the chain segment of PU NPs stretched and their zeta potential decreased, and the primary SPIO-PUs may further aggregate to reach a stable suspension state.…”

Section: Discussionmentioning

confidence: 99%

“…We explain this situation from the aspect of water swelling ratio of various PU NPs because degradation had not occurred at this time. 25 The high water swelling ratio of PU3 NPs may introduce more water to the polymer chains and interfere with the diffusion of hydrophobic drug. At 50°C, the release rate of VK3-PU3 NPs was still lower but closer to that of VK3-PU2, compared to that at 37°C.…”

Section: Discussionmentioning

confidence: 99%

“…A volume of 1 mL of the dispersion of SPIO NPs or SPIO-PU3 NPs, each containing 1 wt% SPIO NPs, was heated using high-frequency oscillating magnetic field. PU3 was selected in this experiment because of its excellent biocompatibility 25 and higher inorganic iron ratio after sonication with SPIO NPs. The dispersion of SPIO NPs or SPIO-PU3 NPs in a glass tube was placed in the middle of the coil and the five-turn coil generated a magnetic field (~20 kA/m).…”

Section: Magnetic Heating Testmentioning

confidence: 99%

“…PU NPs were synthesized according to the procedures described previously. 25 Briefly, prepolymerization was carried out by adding oligodiols, isophorone diisocyanate (IPDI, Evonik Degussa GmbH, Essen, Germany), and the catalyst tin(II)2-ethylhexanoate (T-9, Alfa Aesar) at 75°C for 3 h under nitrogen environment with mechanical stirring at 180 rpm. After this, 2,2-bis(hydroxymethyl)propionic acid (Sigma-Aldrich) and methyl ethyl ketone (MEK) (Avantor Performance Materials, Pennsylvania, PA, USA) were added and made to react for 1 h. The temperature was cooled down to 45°C and triethylamine (Avantor Performance Materials) was added.…”

Section: Synthesis Of Waterborne Biodegradable Pumentioning

confidence: 99%

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A facile method to prepare superparamagnetic iron oxide and hydrophobic drug-encapsulated biodegradable polyurethane nanoparticles

Cheng

Hsu

2017

IJN

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Superparamagnetic iron oxide nanoparticles (SPIO NPs) have a wide range of biomedical applications such as in magnetic resonance imaging, targeting, and hyperthermia therapy. Aggregation of SPIO NPs can occur because of the hydrophobic surface and high surface energy of SPIO NPs. Here, we developed a facile method to encapsulate SPIO NPs in amphiphilic biodegradable polymer. Anionic biodegradable polyurethane nanoparticles (PU NPs) with ~35 nm size and different chemistry were prepared by waterborne processes. SPIO NPs were synthesized by chemical co-precipitation. SPIO NPs were then added to the aqueous dispersion of PU NPs, followed by application of high-frequency (~20 kHz) ultrasonic vibration for 3 min. This method rendered SPIO-PU hybrid NPs (size ~110 nm) suspended in water. SPIO-PU hybrid NPs contained ~50–60 wt% SPIO and retained the superparamagnetic property (evaluated by a magnetometer) as well as high contrast in magnetic resonance imaging. SPIO-PU NPs also showed the ability to provide cell hyperthermic treatment. Using the same ultrasonic method, hydrophobic drug (Vitamin K3 [VK3]) or (9-(methylaminomethyl) anthracene [MAMA]) could also be encapsulated in PU NPs. The VK3-PU or MAMA-PU hybrid NPs had ~35 nm size and different release profiles for PUs with different chemistry. The encapsulation efficiency for VK3 and MAMA was high (~95%) without burst release. The encapsulation mechanism may be attributed to the low glass transition temperature (Tg) and good mechanical compliance of PU NPs. The new encapsulation method involving waterborne biodegradable PU NPs is simple, rapid, and effective to produce multimodular NP carriers.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Magnetic Heating Testmentioning

confidence: 99%

Section: Synthesis Of Waterborne Biodegradable Pumentioning

confidence: 99%

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A facile method to prepare superparamagnetic iron oxide and hydrophobic drug-encapsulated biodegradable polyurethane nanoparticles

Cheng

Hsu

2017

IJN

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“…16 The bioink was a novel aqueous dispersion of PU nanoparticles, which may form hydrogel upon heating without any crosslinker. 18 The modulus of the hydorgel could be easily adjusted by the solid content of the dispersion to mimic the stiffness of neural tissue. The NSC-embedded PU hydrogel constructs were printed by a selfdeveloped fused deposition manufacturing (FDM) equipment.…”

Section: A Novel Bioink For 3d Bioprinting For Neural Tissue Repairmentioning

confidence: 99%

3D bioprinting: A new insight into the therapeutic strategy of neural tissue regeneration

Hsieh

Hsu

2015

Organogenesis

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ABSTRACT. Acute traumatic injuries and chronic degenerative diseases represent the world's largest unmet medical need. There are over 50 million people worldwide suffering from neurodegenerative diseases. However, there are only a few treatment options available for acute traumatic injuries and neurodegenerative diseases. Recently, 3D bioprinting is being applied to regenerative medicine to address the need for tissues and organs suitable for transplantation. In this commentary, the newly developed 3D bioprinting technique involving neural stem cells (NSCs) embedded in the thermoresponsive biodegradable polyurethane (PU) bioink is reviewed. The thermoresponsive and biodegradable PU dispersion can form gel near 37 C without any crosslinker. NSCs embedded within the water-based PU hydrogel with appropriate stiffness showed comparable viability and differentiation after printing. Moreover, in the zebrafish embryo neural deficit model, injection of the NSC-laden PU hydrogels promoted the repair of damaged CNS. In addition, the function of adult zebrafish with traumatic brain injury was rescued after implantation of the 3D-printed NSC-laden constructs. Therefore, the newly developed 3D bioprinting technique may offer new possibilities for future therapeutic strategy of neural tissue regeneration.

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Recent Advances of Novel Materials for3D/4DPrinting in Biomedical Applications

Ahmed

2018

3D and 4D Printing in Biomedical Applications

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Water-based synthesis and processing of novel biodegradable elastomers for medical applications

Abstract: Novel biodegradable nanoelastomers are synthesized. They can self-assemble and generate morphologies in nanometric, micrometric, or bulk scale with tunable properties. They are smart biodegradable materials with potential applications.

Cited by 82 publications

References 52 publications

A facile method to prepare superparamagnetic iron oxide and hydrophobic drug-encapsulated biodegradable polyurethane nanoparticles

A facile method to prepare superparamagnetic iron oxide and hydrophobic drug-encapsulated biodegradable polyurethane nanoparticles

3D bioprinting: A new insight into the therapeutic strategy of neural tissue regeneration

Recent Advances of Novel Materials for3D/4DPrinting in Biomedical Applications

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