Water and Electrolytes in Cervical Mucus from Patients with Cystic Fibrosis

Kopito, Louis; Kosasky, Harold J.; Shwachman, Harry

doi:10.1016/s0015-0282(16)39790-4

Cited by 138 publications

(10 citation statements)

References 5 publications

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“…In two studies SD could not be calculated [ 53 , 54 ]. Also, one study in teeth [ 15 ], one in cervical mucus [ 55 ], one in pancreatic tissue [ 17 ], three in hair [ 16 , 56 , 57 ] were not included in the quantitative analysis, and finally 11 studies were included in the meta-analysis to check the zinc status in circulatory reservoirs ( Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

Zinc status in cystic fibrosis patients; a systematic review and meta-analysis

Malekahmadi,

Soltani,

Pahlavani

et al. 2024

Heliyon

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Section: Resultsmentioning

confidence: 99%

Zinc status in cystic fibrosis patients; a systematic review and meta-analysis

Malekahmadi,

Soltani,

Pahlavani

et al. 2024

Heliyon

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“…Symptoms of CF extend to the reproductive system ( Kaplan et al, 1968 ). Since the 1970 s, wwCF were described having lower fertility rates compared with healthy women ( Kopito et al, 1973 ; Shteinberg et al, 2019 ). Dehydrated cervical mucus and disrupted pH balance can disrupt sperm viability for successful fertilisation ( Kopito et al, 1973 ; Chan et al, 2002 ; Wang et al, 2003 ; Hughan et al, 2019 ).…”

Section: Cystic Fibrosis and Pregnancymentioning

confidence: 99%

“…Since the 1970 s, wwCF were described having lower fertility rates compared with healthy women ( Kopito et al, 1973 ; Shteinberg et al, 2019 ). Dehydrated cervical mucus and disrupted pH balance can disrupt sperm viability for successful fertilisation ( Kopito et al, 1973 ; Chan et al, 2002 ; Wang et al, 2003 ; Hughan et al, 2019 ). Furthermore, CFTR has been identified in the hypothalamus of both rats and humans where the regulation of homeostatic reproductive functions such as gonadotrophin-releasing hormone production may consequently be disrupted in CF patients ( Mulberg et al, 1998 ; Hughan et al, 2019 ; Qiu et al, 2020 ).…”

Section: Cystic Fibrosis and Pregnancymentioning

confidence: 99%

Ocular development after highly effective modulator treatment early in life

Zhu,

Li,

Reyes-Ortega

et al. 2023

Front. Pharmacol.

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Highly effective cystic fibrosis (CF) transmembrane conductance regulator (CFTR) modulator therapies (HEMT), including elexacaftor-tezacaftor-ivacaftor, correct the underlying molecular defect causing CF. HEMT decreases general symptom burden by improving clinical metrics and quality of life for most people with CF (PwCF) with eligible CFTR variants. This has resulted in more pregnancies in women living with CF. All HEMT are known to be able pass through the placenta and into breast milk in mothers who continue on this therapy while pregnant and breast feeding. Toxicity studies of HEMT in young rats demonstrated infant cataracts, and case reports have reported the presence of congenital cataracts in early life exposure to HEMT. This article reviews the evidence for how HEMT influences the dynamic and interdependent processes of healthy and abnormal lens development in the context of HEMT exposure during pregnancy and breastfeeding, and raises questions that remain unanswered.

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“…1); the causes of infertility in female individuals are incompletely understood. Possible etiologies include thick cervical mucus secondary to high expression of dysfunctional CFTR in cervical epithelium, delayed puberty and ovulation, poor nutritional status, abnormal uterine bicarbonate levels, low ovarian reserve, and the presence of dysfunctional CFTR in areas of the brain involved in reproductive functions including hormone levels [3][4][5][6][7][8][9]. In the cervix, because CFTR modulators treat the underlying protein abnormality, both cervical mucous viscosity and pH likely improve and consequently increase fertility [10][11][12].…”

Section: Female Sex Assigned At Birthmentioning

confidence: 99%

The modern landscape of fertility, pregnancy, and parenthood in people with cystic fibrosis

Jain,

Kazmerski,

Taylor-Cousar

2023

Current Opinion in Pulmonary Medicine

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Purpose of review With improved long-term survival and the expanding availability of cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies that treat the underlying genetic defect in cystic fibrosis, more people are interested in parenthood. Cystic fibrosis care centers and people with cystic fibrosis need more information to guide decisions related to parenting. Recent findings Here we present currently available data on fertility, pregnancy, and parenthood in the modern era of cystic fibrosis care. Fertility may be improving in female individuals with cystic fibrosis with the use of CFTR modulator therapies, and there is an associated increase in annual pregnancies. Infertility in male individuals with cystic fibrosis remains approximately 97–98% and is unchanged with CFTR modulators in those already born with cystic fibrosis. As more female individuals with cystic fibrosis experience pregnancy, questions remain about the impact of pregnancy on their health and that of their child. Fortunately, there are multiple routes to becoming a parent; however, more work is needed to understand the impact of pregnancy and parenthood in the context of CF as some previous data suggests potential challenges to the health of parents with cystic fibrosis. Summary We encourage cystic fibrosis care teams to have knowledge and resources available to support the reproductive goals of all individuals with cystic fibrosis.

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Water and Electrolytes in Cervical Mucus from Patients with Cystic Fibrosis

Cited by 138 publications

References 5 publications

Zinc status in cystic fibrosis patients; a systematic review and meta-analysis

Zinc status in cystic fibrosis patients; a systematic review and meta-analysis

Ocular development after highly effective modulator treatment early in life

The modern landscape of fertility, pregnancy, and parenthood in people with cystic fibrosis

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