Wastewater Virus Detection Complements Clinical COVID-19 Testing to Limit Spread of Infection at Kenyon College

Barich, Daniel; Slonczewski, Joan L.

doi:10.1101/2021.01.09.21249505

Cited by 14 publications

(6 citation statements)

References 9 publications

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“…Analyses performed by partners of the OWMN using Ohio's data indicated that the monitored sites showed significant correlation between SARS-CoV-2 concentrations in wastewater and new case counts in monitored communities 14,28,29…”

Section: Contextmentioning

confidence: 99%

Ohio Coronavirus Wastewater Monitoring Network: Implementation of Statewide Monitoring for Protecting Public Health

Bohrerova,

Brinkman,

Chakravarti

et al. 2023

Journal of Public Health Management and Practice

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Context: Prior to the COVID-19 pandemic, wastewater influent monitoring for tracking disease burden in sewered communities was not performed in Ohio, and this field was only on the periphery of the state academic research community. Program: Because of the urgency of the pandemic and extensive state-level support for this new technology to detect levels of community infection to aid in public health response, the Ohio Water Resources Center established relationships and support of various stakeholders. This enabled Ohio to develop a statewide wastewater SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) monitoring network in 2 months starting in July 2020. Implementation: The current Ohio Coronavirus Wastewater Monitoring Network (OCWMN) monitors more than 70 unique locations twice per week, and publicly available data are updated weekly on the public dashboard. Evaluation: This article describes the process and decisions that were made during network initiation, the network progression, and data applications, which can inform ongoing and future pandemic response and wastewater monitoring. Discussion: Overall, the OCWMN established wastewater monitoring infrastructure and provided a useful tool for public health professionals responding to the pandemic.

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Section: Contextmentioning

confidence: 99%

Ohio Coronavirus Wastewater Monitoring Network: Implementation of Statewide Monitoring for Protecting Public Health

Bohrerova,

Brinkman,

Chakravarti

et al. 2023

Journal of Public Health Management and Practice

Self Cite

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“…Currently, several public and private organizations are conducting building surface surveillance and developing data-driven action plans. During the COVID-19 pandemic, many academic institutions ( Betancourt et al, 2020 ; Barich and Slonczewski, 2021 ; Gibas et al, 2021 ; Harris-Lovett et al, 2021 ) and jurisdictional authorities ( Gonzalez et al, 2020 ; Larsen and Wigginton, 2020 ; Medema et al, 2020 ; Peccia et al, 2020 ) around the globe rapidly developed and deployed wastewater and building air HVAC surveillance tools ( Hermesch et al, 2020 ; Horve et al, 2020 ). These data sets provide the opportunity to develop best practices and validate sample collection and processing methods.…”

Section: Identified Capacity Needs and Opportunities For Coordinated Science And Technology Investmentmentioning

confidence: 99%

Critical Capability Needs for Reduction of Transmission of SARS-CoV-2 Indoors

Morrow

Packman

Martinez³

et al. 2021

Front. Bioeng. Biotechnol.

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Coordination of efforts to assess the challenges and pain points felt by industries from around the globe working to reduce COVID-19 transmission in the indoor environment as well as innovative solutions applied to meet these challenges is mandatory. Indoor infectious viral disease transmission (such as coronavirus, norovirus, influenza) is a complex problem that needs better integration of our current knowledge and intervention strategies. Critical to providing a reduction in transmission is to map the four core technical areas of environmental microbiology, transmission science, building science, and social science. To that end a three-stage science and innovation Summit was held to gather information on current standards, policies and procedures applied to reduce transmission in built spaces, as well as the technical challenges, science needs, and research priorities. The Summit elucidated steps than can be taken to reduce transmission of SARS-CoV-2 indoors and calls for significant investments in research to enhance our knowledge of viral pathogen persistence and transport in the built environment, risk assessment and mitigation strategy such as processes and procedures to reduce the risk of exposure and infection through building systems operations, biosurveillance capacity, communication form leadership, and stakeholder engagement for optimal response. These findings reflect the effective application of existing knowledge and standards, emerging science, and lessons-learned from current efforts to confront SARS-CoV-2.

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“…Additionally, in the absence of widespread clinical testing, WBE can act as a health surveillance tool to monitor viral dynamics, as it has been shown to presage new case and subsequent hospitalization rates [ 22 , 25 ]. Accordingly, numerous higher educational institutions have adopted building-level wastewater testing in combination with contact tracing and isolation/quarantine protocols to support campus public health and guide clinical testing resources to “hotspot” locations [ 25 , 26 , 27 , 28 , 29 , 30 ]. Due to its ability to capture population-level health information, WBE will continue to serve as a valuable means to monitor and inform public health programming and response.…”

Section: Introductionmentioning

confidence: 99%

Quantifying the Relationship between SARS-CoV-2 Wastewater Concentrations and Building-Level COVID-19 Prevalence at an Isolation Residence: A Passive Sampling Approach

Acer

Kelly

Lover

et al. 2022

IJERPH

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SARS-CoV-2 RNA loads can be detected in the excreta of individuals with COVID-19 and have demonstrated positive correlations with clinical infection trends. Consequently, wastewater-based epidemiology (WBE) approaches have been implemented globally as a public health surveillance tool to monitor community-level prevalence of infections. The majority of wastewater specimens are gathered as either composite samples via automatic samplers (autosamplers) or grab samples. However, autosamplers are expensive and can be challenging to maintain in cold weather, while grab samples are particularly susceptible to temporal variation when sampling sewage directly from complex matrices outside residential buildings. Passive sampling can provide an affordable, practical, and scalable sampling system while maintaining a reproducible SARS-CoV-2 signal. In this regard, we deployed tampons as passive samplers outside of a COVID-19 isolation unit (a segregated residence hall) at a university campus from 1 February 2021–21 May 2021. Samples (n = 64) were collected 3–5 times weekly and remained within the sewer for a median duration of 24 h. SARS-CoV-2 RNA was quantified using reverse-transcription quantitative polymerase chain reaction (RT-qPCR) targeting the N1 and N2 gene fragments. We quantified the mean viral load captured per individual and the association between the daily viral load and total persons, adjusting for covariates using multivariable models to provide a baseline estimate of viral shedding. Samples were processed through two distinct laboratory pipelines on campus, yielding highly correlated N2 concentrations. Data obtained here highlight the success of passive sampling utilizing tampons to capture SARS-CoV-2 in wastewater coming from a COVID-19 isolation residence, indicating that this method can help inform building-level public health responses.

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Wastewater Virus Detection Complements Clinical COVID-19 Testing to Limit Spread of Infection at Kenyon College

Cited by 14 publications

References 9 publications

Ohio Coronavirus Wastewater Monitoring Network: Implementation of Statewide Monitoring for Protecting Public Health

Ohio Coronavirus Wastewater Monitoring Network: Implementation of Statewide Monitoring for Protecting Public Health

Critical Capability Needs for Reduction of Transmission of SARS-CoV-2 Indoors

Quantifying the Relationship between SARS-CoV-2 Wastewater Concentrations and Building-Level COVID-19 Prevalence at an Isolation Residence: A Passive Sampling Approach

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