2021
DOI: 10.1016/j.envint.2021.106641
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Wastewater treatment plants as a reservoir of integrase and antibiotic resistance genes – An epidemiological threat to workers and environment

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Cited by 115 publications
(62 citation statements)
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“…4 ). Class I integrons carrying intI1 have previously been shown to be the most abundant class of integrons in WWTPs and often contain clinically important ARGs [ 9 , 18 , 72 ]. Concordantly, intI1 was the most abundant integrase detected in all treatments with a mean of 1.14 × 10 4 gene copies per mL and 4.00 × 10 3 gene copies per ng DNA (Fig.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…4 ). Class I integrons carrying intI1 have previously been shown to be the most abundant class of integrons in WWTPs and often contain clinically important ARGs [ 9 , 18 , 72 ]. Concordantly, intI1 was the most abundant integrase detected in all treatments with a mean of 1.14 × 10 4 gene copies per mL and 4.00 × 10 3 gene copies per ng DNA (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…4 ). The presence of intI1 is associated with specific resistance gene families such as streptomycin resistance genes ( aadA ), sulfonamide resistance genes ( sul1 and sul2 ), as well as captured beta-lactam resistance genes [ 18 , 72 74 ]. The findings of low GCN abundance of intI2 across the different treatments (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…4). The presence of intI1 is associated with specific resistance gene families such as streptomycin resistance genes (aadA), sulfonamide resistance genes (sul1 and sul2), as well as captured beta-lactam resistance genes [18,[72][73][74]. The findings of low GCN abundance of intI2 across the different treatments (Fig.…”
Section: Comparison Of Gcn Across Treatments and Timementioning
confidence: 94%
“…Antibiotic therapy is also a risk factor for carriage of AR by individuals. Other potential risk factors include travels to high-risk areas for AR , nutrition (28,29), health status (21,25), and occupation (30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45). However, most of the studies examining potential risk factors focus on high-risk populations such as travelers (8,10,14,18,20,25,26,46), healthcare workers and patients (39,44,45,47,48), swimmers (49)(50)(51), farmers (32)(33)(34)(35)37,38,40,42,43), and slaughterhouse workers (31), and often using small convenience samples of e.g.…”
Section: Introductionmentioning
confidence: 99%