Wastewater-based epidemiology biomarkers: Past, present and future

Choi, Phil M.; Tscharke, Benjamin J.; Donner, Erica; O’Brien, Jake; Grant, Sharon; Kaserzon, Sarit; Mackie, Rachel; O’Malley, Elissa; Crosbie, Nicholas D.; Thomas, Kevin V.; Mueller, Jochen F.

doi:10.1016/j.trac.2018.06.004

Cited by 354 publications

(252 citation statements)

References 261 publications

Supporting

Mentioning

242

Contrasting

Unclassified

Order By: Relevance

“…A large number of international long-term monitoring initiative have since been established worldwide with the most active networks in Europe (European Monitoring Centre for Drugs and Drug Addiction, 2016; Thomas et al, 2012), Australia Lai et al, 2018Lai et al, , 2016O'Brien et al, 2019;Benjamin J. Tscharke et al, 2016) and in the USA (Halden et al, 2019). The successes of WBE that have been demonstrated on global scales have given rise to discussions on future outlooks for the technique (Choi et al, 2018;Daughton, 2018;Kasprzyk-Hordern et al, 2014;Thomas and Reid, 2011). Initially, work was entirely focused upon illicit drug usage, including heroin, cocaine and methamphetamines (Boleda et al, 2007;Castiglioni et al, 2006;Kasprzyk-Hordern et al, 2008;Zuccato et al, 2008) but have since expanded to include a diverse range of other endogenous biomarkers, varying from ones linked to lifestyle choices such as alcohol consumption (Boogaerts et al, 2016;Reid et al, 2011;Rodríguez-Álvarez et al, 2014a), tobacco (Castiglioni et al, 2015;Lai et al, 2017;Rodríguez-Álvarez et al, 2014b;Ben J. Tscharke et al, 2016) and psychoactive substances (Kinyua et al, 2015;Mardal and Meyer, 2014;Reid et al, 2014).…”

Section: Water Fingerprinting Via Wastewater-based Epidemiology -A Nementioning

confidence: 99%

“…WBE has already demonstrated successes in monitoring drug consumption, lifestyle choices and population-wide exposure. Several studies have discussed the future of WBE and the expansion to include biomarkers linked to other aspects of public health, including diet, stress, and biological based monitoring linked with illness (Choi et al, 2018;Daughton, 2018;Gracia-Lor et al, 2017). Due to the wide array of endogenous chemical and biological urinary biomarkers linked with disease, there is clearly huge potential for WBE to be utilised to monitor infectious diseases and the spread of epidemics at the community level (Table 2).…”

Section: Water Fingerprinting For Community-wide Infectious Disease Dmentioning

confidence: 99%

See 1 more Smart Citation

Future perspectives of wastewater-based epidemiology: Monitoring infectious disease spread and resistance to the community level

Sims

Kasprzyk-Hordern

2020

Environment International

447

348

View full text Add to dashboard Cite

Infectious diseases are acknowledged as one of the most critical threats to global public health today. Climate change, unprecedented population growth with accelerated rates of antimicrobial resistance, have resulted in both the emergence of novel pathogenic organisms and the re-emergence of infections that were once controlled. The consequences have led to an increased vulnerability to infectious diseases globally. The ability to rapidly monitor the spread of diseases is key for prevention, intervention and control, however several limitations exist for current surveillance systems and the capacity to cope with the rapid population growth and environmental changes. Wastewater-Based Epidemiology (WBE) is a new epidemiology tool that has potential to act as a complementary approach for current infectious disease surveillance systems and an early warning system for disease outbreaks. WBE postulates that through the analysis of population pooled wastewater, infectious disease and resistance spread, the emergence of new disease outbreak to the community level can be monitored comprehensively and in real-time. This manuscript provides critical overview of current infectious disease surveillance status, as well as it introduces WBE and its recent advancements. It also provides recommendations for further development required for WBE application as an effective tool for infectious disease surveillance.

show abstract

Section: Water Fingerprinting Via Wastewater-based Epidemiology -A Nementioning

confidence: 99%

Section: Water Fingerprinting For Community-wide Infectious Disease Dmentioning

confidence: 99%

Future perspectives of wastewater-based epidemiology: Monitoring infectious disease spread and resistance to the community level

Sims

Kasprzyk-Hordern

2020

Environment International

447

348

View full text Add to dashboard Cite

show abstract

“…In addition to the determination of drug concentrations, the studies on population biomarkers present in wastewater are also increasing [31]. In several studies [28,29], creatinine, a product of muscle metabolism produced at a relatively constant rate throughout the day, has been employed as a normalization factor to account for population variations among sampling periods.…”

Section: Introductionmentioning

confidence: 99%

Wastewater analysis for nicotine, cocaine, amphetamines, opioids and cannabis in New York City

Centazzo

Frederick

Jacox

et al. 2019

Forensic Sciences Research

View full text Add to dashboard Cite

According to current surveys and overdoses data, there is a drug crisis in the USA. Wastewater-based epidemiology (WBE) is an evolving discipline that analyses wastewater samples to detect drugs and metabolites to estimate drug consumption in a certain community. This study demonstrates how drug relative presence could be tracked by testing wastewater, providing real-time results, in different boroughs in New York City throughout 1 year. We developed and fully validated two analytical methods, one for 21 drugs and metabolites, including nicotine, cocaine, amphetamines, opioids and cannabis markers; and another for the normalization factor creatinine. Both methods were performed by liquid chromatography tandem mass spectrometry (LC-MS/MS) using positive electrospray ionization, achieving a limit of quantification of 5-10 ng/L for drugs and metabolites, and 0.01 mg/L for creatinine. These methods were applied to 48 one-time grab wastewater samples collected from six wastewater treatment plants in New York City (Manhattan, The Bronx, Queens and Brooklyn), eight different times throughout 2016, before and after major holidays, including Memorial Day, 4th of July, Labour Day and New Year's. In this study, the drug group normalized concentrations present in the wastewater samples, in decreasing order, were cocaine, nicotine, opioids, cannabis and amphetamines. When looking at individual compounds, the one with the highest normalized concentration was benzoylecgonine (BE), followed by cotinine, morphine and 11-nor-9-carboxy-tetrahydrocannabinol (THCCOOH). To estimate community use, these concentrations were multiplied by the corresponding correction factor, and the most present were THCCOOH, followed by BE, cotinine and morphine. When comparing the treatment plants by drug group (nicotine, cocaine, amphetamines, opioids and cannabis), samples collected from The Bronx had the highest normalized concentrations for nicotine, cocaine and opioids; The Bronx and Manhattan for cannabis; and Manhattan and Queens for amphetamines. In most of the cases, no effect due to holiday was observed. This study provides the first snapshot of drug use in New York City and how that changes between key calendar dates employing wastewater analysis.

show abstract

“…20 Wastewater-based epidemiology (WBE) is a non-invasive technique that can provide spatial and temporal information on the use of and exposure to chemicals within the general population. 19,21,22 It has previously been applied to detect and quantify chemicals such as prescription, over-the-counter and illicit drugs, personal care products, and environmental contaminants in wastewater samples collected from the influent of wastewater treatment plants (WWTPs) and has been used for monitoring purposes. [23][24][25][26][27][28] WBE has the potential for being an intelligence-gathering tool for authorities 25 and data can be compared nationally and internationally for prevention and rehabilitation purposes.…”

mentioning

confidence: 99%

A pilot wastewater‐based epidemiology assessment of anabolic steroid use in Queensland, Australia

Shimko

O’Brien

Barron

et al. 2019

Drug Testing and Analysis

Self Cite

View full text Add to dashboard Cite

Anabolic‐androgenic steroids are synthetic compounds prohibited due to their performance‐enhancing characteristics. The use of these substances is known to cause health‐related issues, which highlights the importance of being able to evaluate the scale of consumption by the general population. However, most available research on the analysis of anabolic steroids is focused on animals and athletes in connection with doping. The potential of wastewater‐based epidemiology as an intelligence tool for the assessment of community level use of anabolic steroids is presented herein. A liquid chromatography tandem mass spectrometry method was developed for the analysis of 10 anabolic‐androgenic steroids and 14 endogenous hormones in influent wastewater. The validated method was applied to sixteen 24‐hour composite wastewater influent samples that were collected over a period of five years from two wastewater treatment plants in Queensland, Australia. Nine investigated compounds were found to be present at concentrations between 14 and 611 ng L−1 which translated into 3–104 mg excreted per 1000 individuals per day. It was concluded that the developed analytical method is suitable for the analysis of AAS in wastewater matrix. Additionally, both the inclusion of metabolites and further investigation into deconjugation by enzymatic hydrolysis would aid in understanding and evaluating community anabolic steroid use. For the first time, this study presents the application of wastewater‐based epidemiology on anabolic‐androgenic steroids in Australia.

show abstract

Wastewater-based epidemiology biomarkers: Past, present and future

Cited by 354 publications

References 261 publications

Future perspectives of wastewater-based epidemiology: Monitoring infectious disease spread and resistance to the community level

Future perspectives of wastewater-based epidemiology: Monitoring infectious disease spread and resistance to the community level

Wastewater analysis for nicotine, cocaine, amphetamines, opioids and cannabis in New York City

A pilot wastewater‐based epidemiology assessment of anabolic steroid use in Queensland, Australia

Contact Info

Product

Resources

About