Waste-minimized, solvent-free and continuous flow synthesis of α-ketoamides from aryl methyl ketones using recyclable CuBr2 catalyst, via bromo intermediate

A copper(ii) bromide/NMO system for α-amination of esters under continuous-flow conditions with reduced catalyst loading

“…The continuous flow process also facilitates the reaction with reduced catalyst loading in comparison to the corresponding batch process. 28 Our lab is working on the development of new synthetic methods using a flow reactor. 29 We attempted to study the α-amination of esters using a CuBr 2 catalyst, as part of our lab's current ongoing research on the development of Cu-catalysed synthetic methods and synthesis of APIs.…”

Metal-free synthesis of selenoesters directly from carboxylic acids using bifunctional selenoureas under batch and continuous-flow conditions

“…Flow chemistry is considered as a green technology for the safe handling of hazardous materials, unstable intermediates, and the reduction of waste and time of reaction. 34,35 We anticipated that continuous-flow conditions may help in maintaining an excellent inert atmosphere and reducing the molecular oxygen mediated oxidation of selenols. The commercial Vaportec R series flow reactor containing fluorinated ethylene propylene (FEP) tubing (volume: 10 mL) was used.…”