Wasp stings (Vespa affinis) induced acute kidney injury following rhabdomyolysis in a 25-year-old woman

Ullah, Parash; Alamgir, Chowdhury; Isha, Ishrat Tahsin; Mahmood, Sultan; Chowdhury, Fazle Rabbi; Abir, Mohammad Zeesan-ul; Manna, Aziz Al; Patwary, Muhammad Ismail

doi:10.15171/jept.2016.08

Cited by 6 publications

(7 citation statements)

References 8 publications

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“…When a person is stung by a Hymenoptera, their venom is introduced into the person’s skin [ 3 ]. Their venom is a concentrated mixture of various biogenic amines, such as kinins, phospholipases, hyaluronidase, histamines, acid phosphatases, etc., and they have direct and indirect hemolytic, neurotoxic, myotoxic, nephrotoxic, hepatotoxic, and vasoactive properties [ 3 , 5 - 6 ]. The responses to Hymenoptera stings are classified as normal local reactions, large local reactions, systemic anaphylactic reactions, systemic toxic reactions, and unusual reactions [ 7 - 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…The allergic manifestation of a wasp sting is well recognized by most, but there are numerous other systemic reactions that have been reported worldwide, namely, rhabdomyolysis, acute kidney injury, acute tubular necrosis, hemolysis, centrilobular necrosis of the liver, disseminated intravascular coagulation, subendocardial necrosis, intracerebral hemorrhage, etc. [ 5 ]. There is also a case report of posterior reversible encephalopathy syndrome occurring in Malaysia, acute pancreatitis occurring in Sri Lanka, and myocardial infarction post anaphylaxis to wasp sting ascribed to Kounis syndrome or allergic angina [ 11 - 13 ].…”

Section: Discussionmentioning

confidence: 99%

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Acute Liver Injury, Rhabdomyolysis, and Acute Kidney Injury Following Mass Envenomation by Wasps in Malaysia

Kaisbain¹,

Rajappan²,

Lim³

et al. 2022

Cureus

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A wasp sting is not uncommon in rural areas, especially in developing countries. While severe allergic reactions to wasp sting are well known, many are unaware of its dangerous systemic toxic reactions. In addition, these systemic toxic reactions occur more gradually as compared to anaphylaxis reactions, which occur rapidly. These deadly systemic reactions can be deceiving, as the local reactions may seem benign and harmless. In an untrained eye with a low index of suspicion, these systemic toxic reactions may be missed without repeated laboratory evaluations and may prove fatal without the timely institution of supportive treatments.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acute Liver Injury, Rhabdomyolysis, and Acute Kidney Injury Following Mass Envenomation by Wasps in Malaysia

Kaisbain¹,

Rajappan²,

Lim³

et al. 2022

Cureus

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“…Maybe if these individuals were stung at many times, they would face severe complications such as muscle destruction, kidney failure, and even death (52)(53)(54)(55). These complications may be seen more in children, elders, and patients whose physical strength is weak (56)(57)(58). Of course velvet ants are not aggressive and no group attacks, like other bees and wasps, have been reported from them so far (59).…”

Section: Discussionmentioning

confidence: 99%

Introducing of a New Sting Agent of Velvet Ant Dentilla sp. (Hymenoptera: Mutillidae) in Kashan, Centerl of Iran (2014 - 2015)

Dehghani

Kassiri

Gharali³

et al. 2018

Arch Clin Infect Dis

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Background: Velvet ants (Mutillid wasps) are among the venomous and stinging insects, which their existence has been reported from different areas of Iran.Objectives: Since no study has been done so far in Iran in regards to their sting, their clinical complications and their sting are studied for the first time in Kashan. Methods:In this descriptive cross-sectional study that was performed during 2014 -2015, 49 individuals stung by velvet ants in the residential areas in Kashan were assessed. Identification of the sting agent was according to the morphologic specifications of the collected samples of the insect in the houses of the injured. Sting complications in the individuals were studied according to the clinical manifestation and the time of the sting, which was from June to September. Results:In this study, the sting agent was identified as velvet ants, Dentilla genus. Most sting cases were in the age group of 11 -20 years with 30.5% and the lowest belonged to the age groups of 31 -40 and 41 -50 years. The first sign of the sting was a severe and sharp pain. The highest percentage of redness in the individuals was 47% in the first day, and the lowest belonged to four or five days after the sting with 2%. Intense itching was one of the main symptoms of velvet ant stings. In the final stages of pain and itching, hemolysis and bruise signs were observed as brown spots.Conclusions: Velvet ant stings have not been reported so far from Kashan. Due to the high cases of stinging in the women carpet weaving workshops, their sitting rooms, and bed rooms, it can be concluded that this arthropod is a domestic pest. Therefore, control and prevention of its potential damages must be programmed accordingly.

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“…The secreted toxic components from venom glands are vital to wasp survival in protection against enemies and in prey hunting [2]. The toxin leads to local allergic reactions; acute renal failure; dysfunction of organs, including hemolytic and hepatitis dysfunction; and even fatal allergy [3,4]. In addition, vespid venom component composes three major proteins, including phospholipase A 1 , protease, and hyaluronidase [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

A Role of Newly Found Auxiliary Site in Phospholipase A1 from Thai Banded Tiger Wasp (Vespa affinis) in Its Enzymatic Enhancement: In Silico Homology Modeling and Molecular Dynamics Insights

Teajaroen

Phimwapi

Daduang

et al. 2020

Toxins

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Phospholipase A1 from Thai banded tiger wasp (Vespa affinis) venom also known as Ves a 1 plays an essential role in fatal vespid allergy. Ves a 1 becomes an important therapeutic target for toxin remedy. However, established Ves a 1 structure or a mechanism of Ves a 1 function were not well documented. This circumstance has prevented efficient design of a potential phospholipase A1 inhibitor. In our study, we successfully recruited homology modeling and molecular dynamic (MD) simulation to model Ves a 1 three-dimensional structure. The Ves a 1 structure along with dynamic behaviors were visualized and explained. In addition, we performed molecular docking of Ves a 1 with 1,2-Dimyristoyl-sn-glycero-3-phosphorylcholine (DMPC) lipid to assess a possible lipid binding site. Interestingly, molecular docking predicted another lipid binding region apart from its corresponding catalytic site, suggesting an auxiliary role of the alternative site at the Ves a 1 surface. The new molecular mechanism related to the surface lipid binding site (auxiliary site) provided better understanding of how phospholipase A1 structure facilitates its enzymatic function. This auxiliary site, conserved among Hymenoptera species as well as some mammalian lipases, could be a guide for interaction-based design of a novel phospholipase A1 inhibitor.

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Wasp stings (Vespa affinis) induced acute kidney injury following rhabdomyolysis in a 25-year-old woman

Cited by 6 publications

References 8 publications

Acute Liver Injury, Rhabdomyolysis, and Acute Kidney Injury Following Mass Envenomation by Wasps in Malaysia

Acute Liver Injury, Rhabdomyolysis, and Acute Kidney Injury Following Mass Envenomation by Wasps in Malaysia

Introducing of a New Sting Agent of Velvet Ant Dentilla sp. (Hymenoptera: Mutillidae) in Kashan, Centerl of Iran (2014 - 2015)

A Role of Newly Found Auxiliary Site in Phospholipase A1 from Thai Banded Tiger Wasp (Vespa affinis) in Its Enzymatic Enhancement: In Silico Homology Modeling and Molecular Dynamics Insights

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