“…Over the last decade, the actin cytoskeleton was shown to play a central role in NKIS formation and maturation, and as a mechanosensor for NK cell responses to mechanical stimuli, beyond its critical role as a scaffold for signaling molecules [ 9 ]. One such molecule, the Wiskott-Aldrich syndrome protein (WASp), activates actin polymerization by serving as a nucleation promoting factor (NPF) for the Arp2/3 complex, a macromolecular machinery that nucleates branched actin filaments in response to cellular signals [ 10 , 11 , 12 ]. Upon NK cell activation, WASp forms a multi-protein complex with WASp-interacting protein (WIP), actin, and myosin, and these associations are abrogated during NK cell inhibition [ 13 , 14 , 15 , 16 ].…”