PurposeThis study aims to evaluate how the structure of medical compression stockings, including three compression levels and five cross-sections from the ankle to the thigh part, will be changed after washing in different conditions and further investigate the effect of the washing parameters on the medical compression stockings.Design/methodology/approachBy washing medical compression stockings in different conditions and measuring the structures (including the density, the girth, the transversal and lengthwise dimension, the weight per unit area and the thickness) of medical compression stockings from the knee to the thigh part.FindingsIt was concluded that the density, the weight per unit and the thickness increase and the girth, the transversal and lengthwise dimension, the weight per unit and the thickness decrease. The change degree of Class one and Class two is greater than Class 3. Moreover, the washing temperature is the most significant factor affecting all the structures of medical compression stockings. Meanwhile, the mechanical actions of the washing machine, like drum speed and washing time, also influence different medical compression stockings structures to different degrees.Research limitations/implicationsThe washing parameter not only includes the temperature and washing cycles but also has other factors, such as the drum speed and washing time. In addition, different kinds of factors will be influenced by each other.Originality/valueThis study can provide consumers advices on the washing of medical compression stockings, and attribute to the optimization of materials and structures to maintain its properties for manufacturers.