WASF3 overexpression affects the expression of circular RNA hsa-circ-0100153, which promotes breast cancer progression by sponging hsa-miR-31, hsa-miR-767-3p, and hsa-miR-935

Mokhtari, Majid; Khoshbakht, Samane; Esmaeil Akbari, Mohammad; Sayyed Sajjad, Moravveji

doi:10.1016/j.heliyon.2023.e22874

Heliyon

2023

DOI: 10.1016/j.heliyon.2023.e22874

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WASF3 overexpression affects the expression of circular RNA hsa-circ-0100153, which promotes breast cancer progression by sponging hsa-miR-31, hsa-miR-767-3p, and hsa-miR-935

Majid Mokhtari,

Samane Khoshbakht,

Mohammad Esmaeil Akbari

et al.

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2024

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Cited by 3 publications

References 52 publications

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Environmental cadmium-induced circRNA-miRNA-mRNA network regulatory mechanism in human normal liver cell model

Qu,

Deng,

Feng

et al. 2024

Current Research in Toxicology

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Environmental cadmium-induced circRNA-miRNA-mRNA network regulatory mechanism in human normal liver cell model

Qu,

Deng,

Feng

et al. 2024

Current Research in Toxicology

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The endogenous association among MMP2/miR-1248/Circ_0087558/miR-643/ MAP2K6 axis can contribute to brain metastasis in basal-like subtype of breast cancer

Khoshbakht,

Zomorodi Anbaji,

Darzi

et al. 2024

Heliyon

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Investigating the interplay between the mir-183/182/96 cluster and the adherens junction pathway in early-stage breast cancer

Noun,

Kurdi,

Maatouk

et al. 2024

Sci Rep

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Although the miR-183/182/96 cluster is overexpressed in breast cancer (BC), little is known about its role in the development of pre-carcinogenic lesions which harbor disrupted adherens junctions (AJ) and may promote BC. Here, we used microRNA and RNA sequencing data from The Cancer Genome Atlas (TCGA) Breast Cancer project to investigate the relationship between the miR-183/182/96 cluster and AJ signaling in early-stage BC. We found that all members of the cluster are significantly overexpressed in early-stage BC, the AJ signaling pathway is enriched for genes down-regulated in early-stage BC, and the AJ signaling pathway is enriched for experimentally validated targets of the miR-183/182/96 cluster. The expression of hsa-miR-182 correlates inversely with the mRNA expression of four of its target genes belonging to the AJ signaling pathway: WASF3, EGFR, MET, and CTNNA3. However, the correlations between hsa-miR-182 and AJ gene expression did not differ significantly between targets and non-targets of hsa-miR-182. This suggests that regulatory effects of microRNAs are less pronounced in cancer, as has been shown by other studies. Furthermore, WASF3, EGFR, and MET are oncogenes that tend to be upregulated in later BC stages, implying that the role of some AJ genes changes with different BC stages. Supplementary Information The online version contains supplementary material available at 10.1038/s41598-024-73632-0.

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WASF3 overexpression affects the expression of circular RNA hsa-circ-0100153, which promotes breast cancer progression by sponging hsa-miR-31, hsa-miR-767-3p, and hsa-miR-935

Cited by 3 publications

References 52 publications

Environmental cadmium-induced circRNA-miRNA-mRNA network regulatory mechanism in human normal liver cell model

Environmental cadmium-induced circRNA-miRNA-mRNA network regulatory mechanism in human normal liver cell model

The endogenous association among MMP2/miR-1248/Circ_0087558/miR-643/ MAP2K6 axis can contribute to brain metastasis in basal-like subtype of breast cancer

Investigating the interplay between the mir-183/182/96 cluster and the adherens junction pathway in early-stage breast cancer

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