Warty Dyskeratoma

Szymanski, Frederick J.

doi:10.1001/archderm.1957.01550160093012

Cited by 96 publications

(14 citation statements)

References 2 publications

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“…1 These variants may be observed not only in the classical dermatoses that coined the term but also in various other skin diseases such as Grover's disease, acantholytic acanthoma, 2 warty dyskeratoma, 3 linear epidermal naevus, 4 naevus corniculatus, 5 oral focal dyskeratosis 6 and acantholytic dermatosis localized to the vulvocrural area. 1 These variants may be observed not only in the classical dermatoses that coined the term but also in various other skin diseases such as Grover's disease, acantholytic acanthoma, 2 warty dyskeratoma, 3 linear epidermal naevus, 4 naevus corniculatus, 5 oral focal dyskeratosis 6 and acantholytic dermatosis localized to the vulvocrural area.…”

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confidence: 99%

A localized variant of paraneoplastic pemphigus: acantholysis associated with malignant melanoma

et al. 2001

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We report a 72-year-old male patient with a nodular malignant melanoma that was associated with focal suprabasal acantholysis (FSA). This phenomenon, which is regarded as an incidental finding by dermatopathologists, may be associated with inflammatory and also neoplastic skin diseases. Haematoxylin and eosin stained sections from an erythematous plaque surrounding the patient's tumour showed FSA, direct immunofluorescence (DIF) and indirect immunofluorescence (IIF) on normal human skin, monkey oesophagus and rat urinary bladder were negative. On electron microscopy few desmosomes could be detected in the basal cell layer of the acantholytic areas and there was a nearly complete loss of these structures in the spinous cell layer. Only remnants of cytoplasmic plaques and keratin filaments could be observed in those areas. In contrast, adherens junctions appeared to be well preserved. An enzyme-linked immunosorbent assay (ELISA) using recombinant fusion proteins as antigens did not show circulating autoantibodies against desmoglein 1 (Dsg1) or desmoglein 3 (Dsg3). In contrast, immunoblotting revealed autoantibodies directed against keratinocyte antigens with a molecular weight of 85 kDa and 250 kDa, the first band corresponding to the molecular weight of comigrating plakoglobin. Immunoprecipitation with patient serum also revealed a 85-kDa band. We conclude that these autoantibodies, probably in conjunction with cofactors produced by the tumour, could play a part in the pathogenesis of this variant of FSA, for which we propose the term 'localized paraneoplastic pemphigus.'

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confidence: 99%

A localized variant of paraneoplastic pemphigus: acantholysis associated with malignant melanoma

et al. 2001

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“…In Szymanski's series [7] of 7 cases, 6 had solitary lesions and in only one of them were there three lesions. None of Graham and Helwig's [8] 50 cases was multiple.…”

Section: Discussionmentioning

confidence: 96%

Darier’s Disease Limited to the Wall of a Cyst

Hyman¹,

Dreizin²

1963

Dermatology

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“…Cases presenting three [2] and multiple [5] lesions have been reported. The case described above had two lesions, histologically proved, and probably a third, left untouched.…”

Section: Discussionmentioning

confidence: 99%