Warthin's Tumors and Their Relationship to Lung Cancer

White, Christine Klimowicz; Williams, Kimberly A.; Rodriguez-Figueroa, Jorge; Langer, Corey J.

doi:10.3109/07357907.2014.979365

Cited by 11 publications

(8 citation statements)

References 12 publications

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“…Most previous studies have not addressed follow up time [8][9][10][11]. However, a study looking at patients with lung cancer and Warthin tumor showed that three patients were diagnosed with lung carcinoma between 1 and 6 years after the diagnosis of Warthin tumor [47].…”

Section: Discussionmentioning

confidence: 99%

Incidence of Non-Salivary Gland Neoplasms in Patients with Warthin Tumor: A Study of 73 Cases

Zaccarini

Khurana

2019

Head and Neck Pathol

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Warthin tumor is the second most common benign parotid neoplasm. Its association with non-salivary gland neoplasms has been sporadically reported. We reviewed clinical records of Warthin tumor diagnosed on aspiration cytology and surgical pathology to determine if there is any association with other extra-salivary gland malignant neoplasms. Computer search was made for all cases of Warthin tumor diagnosed in the parotid gland by aspiration cytology and surgical pathology at our institution between January 2007 and August 2016. Clinical records of all cases were reviewed for any associated malignant neoplasms and any surgical follow up. All available cytology and histologic material was reviewed. Seventy-three patients (mean 66.9, M:F 1.1:1, age range 43 to 87 years) with Warthin tumor were identified. 45 (62%) were diagnosed on aspiration cytology only, 19 (26%) had cytologic diagnosis as well as concordant surgical follow up, and 9 (12%) were diagnosed based on surgical pathology only. Average age for patients with and without secondary malignancy was 70.5-years, and 63.4-years, respectively (p < 0.05). Average pack years for patients with and without secondary malignancy was 45.4, and 39.8, respectively (p > 0.05). Twenty-seven (37.0%) patients harbored a malignant neoplasm. Association of extra salivary gland malignant neoplasms in 37.0% of our cases suggest that the prevalence of secondary non-salivary neoplasms in patients harboring Warthin tumor might have been underestimated. Squamous cell carcinoma was the most commonly associated non-salivary malignant neoplasm. The association of Warthin tumor with smoking plays an important role in this increased rate of malignancy, and this is supported by the fact that smoking is highly associated with head and neck and lung cancers.

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Section: Discussionmentioning

confidence: 99%

Incidence of Non-Salivary Gland Neoplasms in Patients with Warthin Tumor: A Study of 73 Cases

Zaccarini

Khurana

2019

Head and Neck Pathol

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“…Dua et al [13] reported a case with bilateral synchronous and multifocal WT mimicking metastasis from lung cancer, Arora et al [14] reported 3 cases, and Thomas et al [15] reported 2 cases. Although there has been no proven association, a retrospective study by White et al [3] reported that, among 144 patients with WT, 24 (19%) had a concomitant lung cancer, the most common being NSCLC. They suggested that given the association between WT and lung cancer, earlier recognition of these benign lesions might potentially facilitate earlier diagnosis of lung malignancies [3].…”

Section: Discussionmentioning

confidence: 99%

“…Although there has been no proven association, a retrospective study by White et al [3] reported that, among 144 patients with WT, 24 (19%) had a concomitant lung cancer, the most common being NSCLC. They suggested that given the association between WT and lung cancer, earlier recognition of these benign lesions might potentially facilitate earlier diagnosis of lung malignancies [3].…”

Section: Discussionmentioning

confidence: 99%

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Lung cancer and warthin"s tumor: a case report and review of the literature

Zorlu¹,

Atasoy²,

Günal³

et al. 2018

Curr Thorac Surg

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Warthin's tumor (WT) is a salivary gland neoplasm, which is also called as papillary cyst adenoma lymphomatosis. Herein, we present an uncommon coexistence of WT in an 80-year-old patient with PET/CT positive cervical lymph nodes, during the diagnostic workup of a pulmonary mass lesion. Histopathologic diagnosis of the lymph node was reported as Warthin tumor and transthoracic biopsy of the mass as non-small cell lung carcinoma. We want to emphasize that it would be essential to identify patients with WT as an association with lung cancer was suggested in the recent literature.

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“…The negative impact of VitD deficiency has been demonstrated in plasma cell neoplasms, with a direct correlation with low serum VitD levels—a late disease stage according to the International Staging System (ISS)—and higher serum C-reactive protein in a large cohort of patients [ 93 , 94 ]. Similarly, in 2015, researchers reported that increased plasma cells in BM are correlated with VitD levels < 10 ng mL –1 [ 95 ]. In MM patients, most of whom lack vitamin D [ 96 ], this correlation was also valid in a long-term follow-up study, where the risk of progression, development of MBD and osteoporosis, and all-cause mortality was low in patients with adequate VitD levels (>75 nmol L −1 ) [ 97 ].…”

Section: Vitamin D Status In Multiple Myelomamentioning

confidence: 99%

Reviewing the Significance of Vitamin D Substitution in Monoclonal Gammopathies

Innao

Allegra

Ginaldi

et al. 2021

IJMS

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Vitamin D is a steroid hormone that is essential for bone mineral metabolism and it has several other effects in the body, including anti-cancer actions. Vitamin D causes a reduction in cell growth by interrupting the cell cycle. Moreover, the active form of vitamin D, i.e., 1,25-dihydroxyvitamin D, exerts various effects via its interaction with the vitamin D receptor on the innate and adaptive immune system, which could be relevant in the onset of tumors. Multiple myeloma is a treatable but incurable malignancy characterized by the growth of clonal plasma cells in protective niches in the bone marrow. In patients affected by multiple myeloma, vitamin D deficiency is commonly correlated with an advanced stage of the disease, greater risk of progression, the development of pathological fractures, and a worse prognosis. Changes in the vitamin D receptor often contribute to the occurrence and progress of deficiencies, which can be overcome by supplementation with vitamin D or analogues. However, in spite of the findings available in the literature, there is no clear standard of care and clinical practice varies. Further research is needed to better understand how vitamin D influences outcomes in patients with monoclonal gammopathies.

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Warthin's Tumors and Their Relationship to Lung Cancer

Cited by 11 publications

References 12 publications

Incidence of Non-Salivary Gland Neoplasms in Patients with Warthin Tumor: A Study of 73 Cases

Incidence of Non-Salivary Gland Neoplasms in Patients with Warthin Tumor: A Study of 73 Cases

Lung cancer and warthin"s tumor: a case report and review of the literature

Reviewing the Significance of Vitamin D Substitution in Monoclonal Gammopathies

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