Warthin-Like Variant of Papillary Thyroid Carcinoma: An Uncommon Variant

Kumar, Tarun; Nigam, Jitendra Singh; Tewari, Prerna; Jha, Chandan Kumar

doi:10.7759/cureus.12350

Cited by 3 publications

(9 citation statements)

References 15 publications

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“…[3] WLPTC first described by Apel et al was so named due to its resemblance to warthin tumor of salivary gland histologically. [2] WLPTC has a female predilection and occur generally a decade earlier than classic variant with highest prevalence being in the fourth decade. [2] Grossly the size of tumor varies from 3 to 22 mm.…”

Section: Discussionmentioning

confidence: 99%

“…[2] WLPTC has a female predilection and occur generally a decade earlier than classic variant with highest prevalence being in the fourth decade. [2] Grossly the size of tumor varies from 3 to 22 mm. [2] The oncocytic changes seen in WLPTC could be related to Hashimoto's/lymphocytic thyroiditis.…”

Section: Discussionmentioning

confidence: 99%

“…[2] Grossly the size of tumor varies from 3 to 22 mm. [2] The oncocytic changes seen in WLPTC could be related to Hashimoto's/lymphocytic thyroiditis. [4] Dailey et al have demonstrated an association between PTC and Hashimoto's thyroiditis.…”

Section: Discussionmentioning

confidence: 99%

“…For cytological diagnosis the presence of both features is essential. [2] The cytologic diagnosis is difficult due to overlapping features of both PTCs and Hashimoto's thyroiditis [1] WLPTC needs to be distinguished from other oncocyte rich thyroid neoplasm such as tall cell variant of PTC, Hurthle cell carcinoma and Hashimoto's thyroiditis. [1] Tall cell variant show papillae lined by oncocytes whose height is three times more than width of cell and lack lymphoplasmacytic infiltrate in the papillary cores.…”

Section: Discussionmentioning

confidence: 99%

“…WLPTC is a rare variant and was first described in 1995 by Apel et al and is considered to have similar or less aggressive clinical behaviour to classic PTC. [2] Case report Case1 A 27 year old female presented to our institute with complaints of swelling in the neck. Thyroid function test revealed a decreased TSH.…”

Section: Introductionmentioning

confidence: 99%

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Warthin like Variant of Papillary Carcinoma Thyroid with BRAF Mutation

Fonseca

Arya

Lahari

et al. 2021

Indian J Otolaryngol Head Neck Surg

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Warthin like Variant of Papillary Carcinoma Thyroid with BRAF Mutation

Fonseca

Arya

Lahari

et al. 2021

Indian J Otolaryngol Head Neck Surg

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The Warthin-like variant of papillary thyroid carcinomas: a clinicopathologic analysis report of two cases

Zhao,

Zhang,

Hao

et al. 2023

Oncologie

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Obejectives Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma, comparising various subtypes including classical PTC (accounting for approximately 55–65 % of cases) and several variants. The identified variants include papillary microcarcinoma, encapsulated variant, follicular variant, diffuse sclerosing variant, tall cell variant, columnar cell variant, cribriform-morular variant, and Warthin-like variant (WLV-PTC). WLV-PTC is a rare malignant neoplasm. Case presentation The present study introduced two cases of WLV-PTC from Affiliated Hospital of Chengde Medical College in retrospect. The macroscopic characteristics, histological feature, immunophenotyping, gene mutations, local invasion, and distant metastasis of the tumors were observed, and the relevant literature on WLV-PTC was reviewed. The tumor cells exhibited nuclear the characteristics similar to those of classic papillary thyroid carcinoma. Immunohistochemical analysis showed strong positivity for thyroid transcription factor 1, cytokeratin 19, Galectin-3, and CK, weak positivity for thyroglobulin, and the Ki-67 proliferation index ranging from 5 to 10 %. Gene mutation analysis revealed that Case 1 had a BRAF V600E mutation, whereas Case 2 had a wild-type mutation. WLV-PTC has histological features similar to those of Warthin tumor originating from salivary gland. Conclusions The prognosis of WLV-PTC is similar to that of conventional PTC of comparable size and stage.

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Papillary thyroid carcinoma of the Warthin like type, a rare variant: A case report

Akioud

Abainou²,

El-hadri³

et al. 2022

IJPO

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The Warthin-like variant is a rare and relatively unknown entity of papillary thyroid carcinoma. It is frequently associated with Hashimoto's thyroiditis. The cytologic diagnosis is difficult to evaluate because of the overlap of its findings with the classic variant and Hashimoto's thyroiditis. However, this variant has unique morphologic features that make it easily recognizable on histologic examination. These tumors have a resemblance to Warthin's tumor of salivary gland origin.The few case series reported in the literature have suggested that the mean age, sex distribution, circumstances of discovery, and prognosis are the same as those reported for classic papillary thyroid carcinoma.We report here a case of Warthin like variant papillary thyroid carcinoma in a 42-year-old female patient followed for Hashimoto's thyroiditis.

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Warthin-Like Variant of Papillary Thyroid Carcinoma: An Uncommon Variant

Cited by 3 publications

References 15 publications

Warthin like Variant of Papillary Carcinoma Thyroid with BRAF Mutation

Warthin like Variant of Papillary Carcinoma Thyroid with BRAF Mutation

The Warthin-like variant of papillary thyroid carcinomas: a clinicopathologic analysis report of two cases

Papillary thyroid carcinoma of the Warthin like type, a rare variant: A case report

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