Warning Signs and Symptoms of Oral Cancer and its Differential Diagnosis

Muthu, Kavitha; Vaishnavi, Vedam; Ganapathy, Sivadas

doi:10.5530/jyp.2018.10.32

Cited by 7 publications

(3 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…13 White or red patches, non-healing ulcer, oral bleeding, loose teeth, earache, and dysphagia are common symptoms of oral cancer. 21 Very few (5.2%) students were aware of the tongue as the most common site to develop oral cancer. In contrast to this finding, more than half of the students were aware of the tongue as the most common site in other studies.…”

Section: Discussionmentioning

confidence: 99%

Assessment of awareness of oral cancer among nursing students at BPKIHS, Nepal

Keshwar

Sarraf²,

Shrestha³

et al. 2020

JCMC

View full text Add to dashboard Cite

Background: Early recognition of oral cancer is essential for higher cure rate and better prognosis. Nurses can play a significant role in the early diagnosis of cancers. The study aimed to assess the awareness of oral cancer among nursing students. Methods: A cross-sectional survey was conducted among Bachelor of Nursing Students at College of Nursing, B.P. Koirala Institute of Health Sciences. A semi-structured questionnaire was used to collect the sociodemographic data and awareness of cancer. Descriptive statistics were calculated using Statistical Package for Social Sciences version 22.0. Results: Out of 116, 89 (76.7%) students were of age 21-25 years. One hundred and twelve students (96.6%) were aware that various form of tobacco increases risk of oral cancer; however, only 55 (47.4%) students knew alcohol drinking as a risk factor. Only 29 (25.0%) students were aware of loose-fitting denture as a risk factor for oral cancer. Ninety-six (82.8%) students knew white or red patch as possible signs of oral cancer; however, only six (5.2%) students were aware of the most common site of oral cancer. Only 16 (13.8%) students considered that they are adequately trained to screen oral cancer. One hundred and fifteen (99.1%) students demanded more education on oral cancer. Conclusions: This study revealed that nursing students’ awareness of risk factors and the importance of screening of oral cancer is suboptimal. It highlights a need for basic education on oral cancer to make them more aware and further competent toward oral cancer screening and referral.

show abstract

Section: Discussionmentioning

confidence: 99%

Assessment of awareness of oral cancer among nursing students at BPKIHS, Nepal

Keshwar

Sarraf²,

Shrestha³

et al. 2020

JCMC

View full text Add to dashboard Cite

show abstract

“…OSCC symptoms include recurrent mouth sores or ulcers that do not heal, red or white patches in the mouth, pain while swallowing, a chronic sore throat, a lump or mass in the mouth or neck, ear ache, and changes in speech or voice [7]. Notably, if any of these symptoms are present, it is important to consult a health care professional for further evaluation.…”

Section: Introductionmentioning

confidence: 99%

Epigenetic Regulation in Oral Squamous Cell Carcinoma Microenvironment: A Comprehensive Review

Mesgari,

Esmaelian,

Nasiri

et al. 2023

Cancers

View full text Add to dashboard Cite

Oral squamous cell carcinoma (OSCC) is a prevalent and significant type of oral cancer that has far-reaching health implications worldwide. Epigenetics, a field focused on studying heritable changes in gene expression without modifying DNA sequence, plays a pivotal role in OSCC. Epigenetic changes, encompassing DNA methylation, histone modifications, and miRNAs, exert control over gene activity and cellular characteristics. In OSCC, aberrant DNA methylation of tumor suppressor genes (TSG) leads to their inactivation, subsequently facilitating tumor growth. As a result, distinct patterns of gene methylation hold promise as valuable biomarkers for the detection of OSCC. Oral cancer treatment typically involves surgery, radiation therapy, and chemotherapy, but even with these treatments, cancer cells cannot be effectively targeted and destroyed. Researchers are therefore exploring new methods to target and eliminate cancer cells. One promising approach is the use of epigenetic modifiers, such as DNA methyltransferase (DNMT) inhibitors and histone deacetylase (HDAC) inhibitors, which have been shown to modify abnormal epigenetic patterns in OSCC cells, leading to the reactivation of TSGs and the suppression of oncogenes. As a result, epigenetic-targeted therapies have the potential to directly alter gene expression and minimize side effects. Several studies have explored the efficacy of such therapies in the treatment of OSCC. Although studies have investigated the efficacy of epigenetic therapies, challenges in identifying reliable biomarkers and developing effective combination treatments are acknowledged. Of note, epigenetic mechanisms play a significant role in drug resistance in OSCC and other cancers. Aberrant DNA methylation can silence tumor suppressor genes, while alterations in histone modifications and chromatin remodeling affect gene expression related to drug metabolism and cell survival. Thus, understanding and targeting these epigenetic processes offer potential strategies to overcome drug resistance and improve the efficacy of cancer treatments in OSCC. This comprehensive review focuses on the complex interplay between epigenetic alterations and OSCC cells. This will involve a deep dive into the mechanisms underlying epigenetic modifications and their impact on OSCC, including its initiation, progression, and metastasis. Furthermore, this review will present the role of epigenetics in the treatment and diagnosis of OSCC.

show abstract

“…In the advanced stage of the disease, patients present with a number of clinical presentations including ulceration or growth in the oral cavity, loosening of teeth, pain, malodour (halitosis), excessive salivation, bleeding, difficulty in speaking and swallowing, referred pain to the ear, swelling and ulceration of the face and neck swelling. The symptoms vary depending on the site of involvement (Muthu, Vaishnavi, & Sivadas, 2018). The exact aetiology of OSCC is unknown however it has been strongly associated with tobacco use and alcohol consumption, human papilloma virus and some other risk factors (Bugshan & Farooq, 2020;Mehrotra &Yadav, 2006).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Characteristics of Oral Squamous Cell Carcinoma in Fiji: A Retrospective Study

Dean¹,

Gavidi²,

Mohammadnezhad³

et al. 2022

GJHS

View full text Add to dashboard Cite

BACKGROUND: Oral squamous cell carcinoma (OSCC) is malignant epithelial neoplasm that affects the oral cavity. Despite the large number of studies on OSCC in the literature, details on the demographic profile of these lesions in different populations are limited, especially amongst the Fijian population, thus this study aimed to determine the prevalence and characteristics of OSCC cases diagnosed from 2011 to 2015 at the Colonial War Memorial Hospital (CWMH), Suva, Fiji Islands. MATERIALS & METHODS: A retrospective quantitative study was carried out at the CWMH Histology department looking at OSCC cases diagnosed from 2011–2015. All confirmed cases were included in the study and excluded cases were suspected cases that were pending diagnosis and children. An extraction sheet was used for data collection which was designed to meet the requirements of study finding. This data was entered in SPSS software and then analyzed using the simple analytical tool as bar graphs and tables.  RESULTS: There were 74 OSCC cases diagnosed in the study period. The occurrence of OSCC cases over the 5-year period was fluctuant with the year 2013 recording the highest number of cases (24 cases, 32%). During the reported period, more men suffered (53 cases, 72%) from this condition with the tongue (40%) being the commonest oral cancer site followed by the lip and vermillion border (28%). Individuals in the 40 to 60 years’ age group (35 cases, 47.3%) were mostly affected with the I-taukei population (38 cases, 51.4%) recording the highest occurrence of OSCC. The results show that, the common occurrence is the tongue (40.5%) while the least presentation sight is Buccal mucosa/buccal sulcus area (8.1%). CONCLUSION: The study concluded that more men suffer from oral squamous cell carcinoma compared to woman and the ethnicity that was most affected was I-taukei population. More detailed record keeping and reporting of oral cancer is needed to help evaluate progress in controlling oral cancer in the Fiji Islands. This availability of geographic data would further assist the Ministry of Health of Fiji in data collection and planning of preventative activities

show abstract

Warning Signs and Symptoms of Oral Cancer and its Differential Diagnosis

Cited by 7 publications

References 29 publications

Assessment of awareness of oral cancer among nursing students at BPKIHS, Nepal

Assessment of awareness of oral cancer among nursing students at BPKIHS, Nepal

Epigenetic Regulation in Oral Squamous Cell Carcinoma Microenvironment: A Comprehensive Review

Prevalence and Characteristics of Oral Squamous Cell Carcinoma in Fiji: A Retrospective Study

Contact Info

Product

Resources

About