Warming drives ecological community changes linked to host-associated microbiome dysbiosis

Greenspan, Sasha E.; Migliorini, Gustavo H.; Lyra, Mariana L.; Pontes, Mariana Retuci; Carvalho, Tamilie; Ribeiro, Luisa P.; Moura-Campos, Diego; Haddad, Célio F. B.; Toledo, Luı́s Felipe; Romero, Gustavo Q.; Becker, C. Guilherme

doi:10.1038/s41558-020-0899-5

Cited by 63 publications

(54 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The impact of E. coli genetic diversity, virulence and AMR on biodiversity and conservation of wild animals is largely unknown. Stress, such as that resulting from habitat destruction, decreased food availability and other negative outcomes of anthropogenic environmental change, has been implicated as a factor related to shifts in wild animal microbiomes toward lower gut bacterial diversity and higher pathogen load [ 4 , 5 ]. This could lead to higher rates of pathogen and AMR shed into the environment and thus increase transmission among wild animals and potentially into human populations.…”

Section: Introductionmentioning

confidence: 99%

The under-investigated wild side ofEscherichia coli: genetic diversity, pathogenicity and antimicrobial resistance in wild animals

Lagerstrom

Hadly

2021

Proc. R. Soc. B.

View full text Add to dashboard Cite

A striking paucity of information exists on Escherichia coli in wild animals despite evidence that they harbour pathogenic and antimicrobial-resistant E. coli in their gut microbiomes and may even serve as melting pots for novel genetic combinations potentially harmful to human health. Wild animals have been implicated as the source of pathogenic E. coli outbreaks in agricultural production, but a lack of knowledge surrounding the genetics of E. coli in wild animals complicates source tracking and thus contamination curtailment efforts. As human populations continue to expand and invade wild areas, the potential for harmful microorganisms to transfer between humans and wildlife increases. Here, we conducted a literature review of the small body of work on E. coli in wild animals. We highlight the geographic and host taxonomic coverage to date, and in each, identify significant gaps. We summarize the current understanding of E. coli in wild animals, including its genetic diversity, host and geographic distribution, and transmission pathways within and between wild animal and human populations. The knowledge gaps we identify call for greater research efforts to understand the existence of E. coli in wild animals, especially in light of the potentially strong implications for global public health.

show abstract

Section: Introductionmentioning

confidence: 99%

The under-investigated wild side ofEscherichia coli: genetic diversity, pathogenicity and antimicrobial resistance in wild animals

Lagerstrom

Hadly

2021

Proc. R. Soc. B.

View full text Add to dashboard Cite

show abstract

“…In the present study, landuse significantly altered the diversity of soil faunal microbiome, which also confirmed this viewpoint. A recent study showed that anthropogenic climate warming altered animal microbiomes [ 64 ]. Thus, more attention should be focused on potential changes to soil faunal microbiomes under global change.…”

Section: Discussionmentioning

confidence: 99%

Trophic level drives the host microbiome of soil invertebrates at a continental scale

et al. 2021

View full text Add to dashboard Cite

Background Increasing our knowledge of soil biodiversity is fundamental to forecast changes in ecosystem functions under global change scenarios. All multicellular organisms are now known to be holobionts, containing large assemblages of microbial species. Soil fauna is now known to have thousands of species living within them. However, we know very little about the identity and function of host microbiome in contrasting soil faunal groups, across different terrestrial biomes, or at a large spatial scale. Here, we examined the microbiomes of multiple functionally important soil fauna in contrasting terrestrial ecosystems across China. Results Different soil fauna had diverse and unique microbiomes, which were also distinct from those in surrounding soils. These unique microbiomes were maintained within taxa across diverse sampling sites and in contrasting terrestrial ecosystems. The microbiomes of nematodes, potworms, and earthworms were more difficult to predict using environmental data, compared to those of collembolans, oribatid mites, and predatory mites. Although stochastic processes were important, deterministic processes, such as host selection, also contributed to the assembly of unique microbiota in each taxon of soil fauna. Microbial biodiversity, unique microbial taxa, and microbial dark matter (defined as unidentified microbial taxa) all increased with trophic levels within the soil food web. Conclusions Our findings demonstrate that soil animals are important as repositories of microbial biodiversity, and those at the top of the food web harbor more diverse and unique microbiomes. This hidden source of biodiversity is rarely considered in biodiversity and conservation debates and stresses the importance of preserving key soil invertebrates.

show abstract

“…Rather, similar dynamics in the microbiome‐epigenome‐immunity axis may have occurred in response to past non‐anthropogenic climate change and contributed to the evolutionary trajectory of our and other species. [ 172 ] To further explore the consequences of these ideas in humans, a closer look at the microbiome‐epigenome‐immunity axis is warranted. This axis connects two so‐far insufficiently interlinked fields of research: human health and human evolution.…”

Section: Discussionmentioning

confidence: 99%

Global climate change, diet, and the complex relationship between human host and microbiome: Towards an integrated picture

et al. 2021

View full text Add to dashboard Cite

Dietary changes can alter the human microbiome with potential detrimental consequences for health. Given that environment, health, and evolution are interconnected, we ask: Could diet-driven microbiome perturbations have consequences that extend beyond their immediate impact on human health? We address this question in the context of the urgent health challenges posed by global climate change. Drawing on recent studies, we propose that not only can diet-driven microbiome changes lead to dysbiosis, they can also shape life-history traits and fuel human evolution. We posit that dietary shifts prompt mismatched microbiome-host genetics configurations that modulate human longevity and reproductive success. These mismatches can also induce a heritable intra-holobiont stress response, which encourages the holobiont to reestablish equilibrium within the changed nutritional environment. Thus, while mismatches between climate change-related genetic and epigenetic configurations within the holobiont increase the risk and severity of diseases, they may also affect life-history traits and facilitate adaptive responses. These propositions form a framework that can help systematize and address climate-related dietary challenges for policy and health interventions.

show abstract

Warming drives ecological community changes linked to host-associated microbiome dysbiosis

Cited by 63 publications

References 68 publications

The under-investigated wild side ofEscherichia coli: genetic diversity, pathogenicity and antimicrobial resistance in wild animals

The under-investigated wild side ofEscherichia coli: genetic diversity, pathogenicity and antimicrobial resistance in wild animals

Trophic level drives the host microbiome of soil invertebrates at a continental scale

Global climate change, diet, and the complex relationship between human host and microbiome: Towards an integrated picture

Contact Info

Product

Resources

About