Warm ischemia lung protection with pinacidil: an ATP regulated potassium channel opener

Tang, Daniel; Pavot, Dawn R.; Mouria, Michelle M; Holwitt, Dana; Cohen, Noal

doi:10.1016/s0003-4975(03)00452-1

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…81 Activation of mitochondrial K ATP channels after IP was protective in murine, rabbit and canine organs exposed to subsequent I/R. 17,82,83 Another possible mechanism of protection is by inhibition of mitochondrial permeability transition pores (MPTP). 84 Opening of these pores within a few minutes of reperfusion in conditions of increased Ca CC and Pi, ATP depletion, oxidative stress and increased matrix pH, can initiate apoptotic cell death.…”

Section: Mechanism Of Protectionmentioning

confidence: 99%

Ischaemic Preconditioning Protects Against Ischaemia/Reperfusion Injury: Emerging Concepts

Pasupathy

Homer‐Vanniasinkam

2005

European Journal of Vascular and Endovascular Surgery

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IP utilises endogenous mechanisms in skeletal muscle, liver, lung, kidney, intestine and brain in animal models to convey varying degrees of protection from I/R injury. To date there are few human studies, but recent reports suggest that human liver, lung and skeletal muscle acquire similar protection after IP. Specifically, preconditioned tissues exhibit reduced energy requirements, altered energy metabolism, better electrolyte homeostasis and genetic re-organisation, giving rise to the concept of 'ischaemia tolerance'. IP also induces 'reperfusion tolerance' with less reactive oxygen species and activated neutrophils released, reduced apoptosis and better microcirculatory perfusion compared to non-preconditioned tissue. Systemic I/R injury is also diminished by preconditioning. IP is ubiquitous but more research is required to fully translate these findings to the clinical arena.

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Section: Mechanism Of Protectionmentioning

confidence: 99%

Ischaemic Preconditioning Protects Against Ischaemia/Reperfusion Injury: Emerging Concepts

Pasupathy

Homer‐Vanniasinkam

2005

European Journal of Vascular and Endovascular Surgery

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Ischemic Preconditioning and Lung Preservation

Chambers

Fallouh²,

Kassem³

2010

Principles of Pulmonary Protection in Heart Surgery

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ATP-dependent potassium channels as a key target for the treatment of myocardial and vascular dysfunction

Pollesello

Mebazaa

2004

Current Opinion in Critical Care

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The most recent data on the physiologic roles of sarcolemmal and mitochondrial ATP-dependent potassium channels and the pharmacology of potassium channel openers in the cardiovascular system are summarized and discussed. Finally, the effects of potassium channel opener drugs including minoxidil, nicorandil, pinacidil, bimakalin, and levosimendan, a dual-action potassium channel opener and calcium sensitizer with inodilator and cardioprotective activity, are discussed.

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Warm ischemia lung protection with pinacidil: an ATP regulated potassium channel opener

Cited by 3 publications

References 14 publications

Ischaemic Preconditioning Protects Against Ischaemia/Reperfusion Injury: Emerging Concepts

Ischaemic Preconditioning Protects Against Ischaemia/Reperfusion Injury: Emerging Concepts

Ischemic Preconditioning and Lung Preservation

ATP-dependent potassium channels as a key target for the treatment of myocardial and vascular dysfunction

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