Warfarin-induced skin necrosis progressing to calciphylaxis

Breakey, William; Hall, Catriona; Jones, Simon Vann; Husain, Akhtar; Kernohan, Michael

doi:10.1016/j.bjps.2014.05.053

Cited by 8 publications

(7 citation statements)

References 5 publications

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“…Drawing these aspects together, Hayashi et al [5] proposed a diagnostic criteria. Key differential diagnosis (owing to their similar clinical appearance) include warfarin-induced skin necrosis, cholesterol embolisation, pyoderma gangrenosum and primary vasculitis [15][16][17]. The history in this case did not indicate these alternatives.…”

Section: Accepted Manuscriptmentioning

confidence: 81%

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Calciphylaxis – A case study in a patient with Maori heritage

Kingi

Grech

Lam

et al. 2016

Journal of Tissue Viability

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This case history describes a rare complaint -Calciphylaxis, seen in a New Zealand Maori patient undergoing renal dialysis. This condition causes non-healing tissue ulceration, typically with sepsis and is associated with a very high mortality rate. The need for vigilance among health professionals is highlighted, including the risk factors that may faciliate an early diagnosis; together with the value associated with a multi-disciplinary team approach to management.

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Section: Accepted Manuscriptmentioning

confidence: 81%

“…However, surgical debribement is controversial owing to vasculopathy [2,15]. Debridement reportedly increases one-year survival rates [21], but requires experienced teams owing to the complexity of these wounds [6,22].…”

Section: Managementmentioning

confidence: 99%

Calciphylaxis – A case study in a patient with Maori heritage

Kingi

Grech

Lam

et al. 2016

Journal of Tissue Viability

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“…Pharmaceutical options include calcimimetic agents such as cinacalcet that suppress parathyroid hormone, bisphosphonates, and sodium thiosulphate. 2,6,14-17…”

Section: Discussionmentioning

confidence: 99%

A Case of Nonuremic Calciphylaxis Treated Effectively With Systemic Corticosteroids

2015

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Calciphylaxis is a syndrome of systemic calcification of the arteries leading to painful tissue necrosis and ulceration. The disease has a high mortality rate with no clear etiology. There is a strong correlation of calciphylaxis with end-stage renal disease, but it can also affect people with normal renal function. Treatment of the disease has been successful at times with various modalities, but in the case of systemic corticosteroids, there is conflicting evidence. In this case report, the authors present a patient with acute nonuremic calciphylaxis who responded very positively to systemic corticosteroids.

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“…Ils auraient également un effet direct sur le phénomène de calcification vasculaire [9]. Nous n'en avons pas l'expérience dans notre cas ; par ailleurs, le rôle des AVK est clairement établi car certaines protéines impliquées dans le phénomène de calcification vasculaire sont vitamine K dépendantes [15]. Cependant, l'utilisation des héparines en injection sous-cutanée peut aussi être à l'origine de lésions de calciphylaxie par les microtraumatismes engendrés.…”

Section: Discussionunclassified