Warfarin-induced Necrosis of the Skin

Warfarin-induced skin necrosis

“…1,[8][9][10][11] The first descriptions of this disorder came from the work of McLean 12 in 1916 and, later, Flood et al 13 in 1943 in the form of ''thrombophlebitis migrans disseminata'' of the breast. 8 Thirteen additional cases were later reported by Verhagen 3 in 1954 that identified warfarin as the causative agent of skin necrosis.…”

“…1,[8][9][10][11] The first descriptions of this disorder came from the work of McLean 12 in 1916 and, later, Flood et al 13 in 1943 in the form of ''thrombophlebitis migrans disseminata'' of the breast. 8 Thirteen additional cases were later reported by Verhagen 3 in 1954 that identified warfarin as the causative agent of skin necrosis. 1,8 This complication has a high propensity for involvement of areas with increased subcutaneous fat such as the abdomen, buttocks, thighs, legs, and mammary tissue in girls and women (Fig 5), although presentation in other areas including the arms, back, and penis have also been reported.…”

“…8 Thirteen additional cases were later reported by Verhagen 3 in 1954 that identified warfarin as the causative agent of skin necrosis. 1,8 This complication has a high propensity for involvement of areas with increased subcutaneous fat such as the abdomen, buttocks, thighs, legs, and mammary tissue in girls and women (Fig 5), although presentation in other areas including the arms, back, and penis have also been reported. 1,3,8,[14][15][16] Acral involvement is not typical.…”

“…1,8 This complication has a high propensity for involvement of areas with increased subcutaneous fat such as the abdomen, buttocks, thighs, legs, and mammary tissue in girls and women (Fig 5), although presentation in other areas including the arms, back, and penis have also been reported. 1,3,8,[14][15][16] Acral involvement is not typical. 15 Approximately one third of patients are affected in multiple sites.…”

La calciphylaxie et ses manifestations stomatologiques

“…D'autres hypothèses ont été proposées par De Franzo et al 17 , comme par exemple, une hypersensibilité immunologique à la warfarine ou une toxicité de la warfarine.…”