“…Nowadays, VK is quite well known in vertebrates to be required for blood coagulation [ 35 , 36 , 37 ], skeletal and joint tissues [ 19 , 38 , 39 , 40 , 41 , 42 ], and pathological calcification and inflammation [ 37 , 43 , 44 , 45 ]. There are some reports on their potential role on redox homeostasis [ 41 , 46 , 47 ], sphingolipid [ 48 , 49 ] and glucose metabolism [ 50 ], neural development and cognitive capacities [ 20 , 48 , 51 , 52 ], as well as angiogenesis [ 53 ]. Furthermore, some evidences have been presented regarding the potential role of VK on the reproduction of mammalian [ 54 , 55 ] and fish species [ 37 , 49 , 55 ].…”