Want to Cure Cancer? Then Revisit the Past; “Warburg Was Correct”, Cancer Is a  Metabolic Disease

Elliott, Robert L.; Xian, Jing; Head, Jonathan F.

doi:10.4236/jct.2014.53036

Cited by 5 publications

(1 citation statement)

References 49 publications

(35 reference statements)

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“…The importance of cancer as a metabolic disease was described in detail in our paper entitled: Want to Cure Cancer? Then Revisit the Past; "Warburg was Correct," Cancer is a Metabolic Disease [15].…”

Section: Cancer Metabolism and Metabolic Therapymentioning

confidence: 99%

Improving 21<sup>st</sup> Century Cancer Therapy: Correcting Treatment Paradoxes and Combining Integrative and Conventional Oncology

Elliott¹,

Jiang²,

Baucom³

2020

JCT

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Recently there have been many advances in cancer treatment, however, treatment results would be much better if clinical oncologists were educated on the research of cancer metabolism and basic cancer immunology. Many medical oncologists have deficiency in these areas and are devoted to treatment protocols and totally against integrative oncology. One neglected problem is a lack of attention to the cancer patient's host immunity, which should be evaluated at diagnosis. This huge barrier between integrative and conventional oncology should be eliminated for the benefit of the cancer patient. This communication is an attempt to resolve these important treatment details and bring awareness to this problem.

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Section: Cancer Metabolism and Metabolic Therapymentioning

confidence: 99%

Improving 21<sup>st</sup> Century Cancer Therapy: Correcting Treatment Paradoxes and Combining Integrative and Conventional Oncology

Elliott¹,

Jiang²,

Baucom³

2020

JCT

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Multi-dimensional roles of ketone bodies in cancer biology: Opportunities for cancer therapy

Feng

Wang

Liu

et al. 2019

Pharmacological Research

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NADH as a cancer medicine

Forrest

2015

Preprint

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We propose that NADH will exert a specific kill action against some cancers. NADH is a natural metabolite. We envisage a low side effect profile and that NADH therapy will, additionally, combat the wastage and weakness of cancer patients, which can be the cause of death in some cases. Significantly, NADH can be administered orally and has already cleared clinical trials, all be it for other pathologies. BackgroundAerobic respiration consists of glycolysis in the cytoplasm and in the mitochondria: the Krebs cycle and oxidative phosphorylation (OXPHOS) [1,2]. It requires O 2 and net yields 30 ATPs from one glucose molecule. Anaerobic respiration, consisting of glycolysis only, does not require O 2 but produces merely 2 ATPs from one glucose molecule. When O 2 is available, normal animal cells tend to favour aerobic respiration because of its higher ATP yield.Aerobic glycolysis is the sole use of glycolysis to produce ATP, even in the presence of O 2 . Pyruvate and NADH, the outputs of glycolysis, are not fed into the further, mitochondrial steps of the Krebs cycle and OXPHOS to gain a higher ATP yield; despite the presence of O 2 . Pyruvate is converted to lactate, which requires all the glycolytic NADH output to be converted to NAD + , and this lactate is then excreted from the cell. So, aerobic glycolysis does not net output any NADH. Cancer cells use aerobic glycolysis some or all of the timeCancer cells produce ATP through aerobic glycolysis (Warburg effect) some or all of the time [3][4][5][6][7]. This metabolic fingerprint is already exploited clinically to diagnose cancer using the radiolabeled glucose analogue -18 Fluoro-deoxyglucose (FDG) -in positron emission tomography (PET) [8]. Cancer cells utilising aerobic glycolysis have higher glucose uptake rates than surrounding, untransformed cells utilising aerobic respiration. It is this disparity that permits tumour identification. The vast majority of metastatic tumours are highly glycolytic (>90%) [9-10] and it may be that all of them are, but not all can be resolved at the present sensitivity and selectivity of the technique [11] e.g. those smaller than 0.8 cm 3 .

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Want to Cure Cancer? Then Revisit the Past; “Warburg Was Correct”, Cancer Is a Metabolic Disease

Cited by 5 publications

References 49 publications

Improving 21<sup>st</sup> Century Cancer Therapy: Correcting Treatment Paradoxes and Combining Integrative and Conventional Oncology

Improving 21<sup>st</sup> Century Cancer Therapy: Correcting Treatment Paradoxes and Combining Integrative and Conventional Oncology

Multi-dimensional roles of ketone bodies in cancer biology: Opportunities for cancer therapy

NADH as a cancer medicine

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Want to Cure Cancer? Then Revisit the Past; “Warburg Was Correct”, Cancer Is a Metabolic Disease

Cited by 5 publications

References 49 publications

Improving 21&lt;sup&gt;st&lt;/sup&gt; Century Cancer Therapy: Correcting Treatment Paradoxes and Combining Integrative and Conventional Oncology

Improving 21&lt;sup&gt;st&lt;/sup&gt; Century Cancer Therapy: Correcting Treatment Paradoxes and Combining Integrative and Conventional Oncology

Multi-dimensional roles of ketone bodies in cancer biology: Opportunities for cancer therapy

NADH as a cancer medicine

Contact Info

Product

Resources

About

Improving 21<sup>st</sup> Century Cancer Therapy: Correcting Treatment Paradoxes and Combining Integrative and Conventional Oncology

Improving 21<sup>st</sup> Century Cancer Therapy: Correcting Treatment Paradoxes and Combining Integrative and Conventional Oncology