Waning and aging of cellular immunity to<i>B. pertussis</i>

Twillert, Inonge van; Han, Wanda G. H.; van, Cécile A. C. M.

doi:10.1093/femspd/ftv071

Cited by 27 publications

(28 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The recent resurgence of pertussis is particularly associated with children aged 6 to 11 years or adolescents and young adults and has been linked to the waning of pertussis-specific immunity, despite the addition of a booster vaccination with the aP vaccine in this age bracket (15,(36)(37)(38)(39)(40). It would thus appear that a key difference or differences exist in pertussis immunity as a function of the original childhood vaccination with aP compared with wP.…”

Section: Resultsmentioning

confidence: 99%

Th1/Th17 polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters

Antunes¹,

Babor²,

Carpenter³

et al. 2018

Journal of Clinical Investigation

108

110

View full text Add to dashboard Cite

In the mid-1990s, whole-cell pertussis (wP) vaccines were associated with local and systemic adverse events that prompted their replacement with acellular pertussis (aP) vaccines in many high-income countries. In the past decade, rates of pertussis disease have increased in children receiving only aP vaccines. We compared the immune responses to aP boosters in individuals who received their initial doses with either wP or aP vaccines using activation-induced marker (AIM) assays. Specifically, we examined pertussis-specific memory CD4+ T cell responses ex vivo, highlighting a type 2/Th2 versus type 1/Th1 and Th17 differential polarization as a function of childhood vaccination. Remarkably, after a contemporary aP booster, cells from donors originally primed with aP were (a) associated with increased IL-4, IL-5, IL-13, IL-9, and TGF-β and decreased IFN-γ and IL-17 production, (b) defective in their ex vivo capacity to expand memory cells, and (c) less capable of proliferating in vitro. These differences appeared to be T cell specific, since equivalent increases of antibody titers and plasmablasts after aP boost were seen in both groups. In conclusion, our data suggest that there are long-lasting effects and differences in polarization and proliferation of T cell responses in adults originally vaccinated with aP compared with those that initially received wP, despite repeated acellular boosters.

show abstract

Section: Resultsmentioning

confidence: 99%

Th1/Th17 polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters

Antunes¹,

Babor²,

Carpenter³

et al. 2018

Journal of Clinical Investigation

108

110

View full text Add to dashboard Cite

show abstract

“…Several immunological mechanisms have been proposed to explain the decreasing efficacy of B. pertussis vaccination [8–10, 22], including the possibility that vaccination with aP induces a qualitatively different T cell response, at the level of which antigens and epitopes are recognized, and/or the phenotypes of T cells recognizing them. Surprisingly, a comparison of immunological parameters observed following aP booster immunization in teenagers originally primed in childhood with aP versus older adults originally primed with wP has not been performed.…”

Section: Introductionmentioning

confidence: 99%

Th1 versus Th2 T cell polarization by whole-cell and acellular childhood pertussis vaccines persists upon re-immunization in adolescence and adulthood

Bancroft

Dillon

Antunes

et al. 2016

Cellular Immunology

View full text Add to dashboard Cite

The recent increase in cases of whooping cough among teenagers in the US suggests that the acellular Bordetella pertussis vaccine (aP) that became standard in the mid 1990s might be relatively less effective than the whole-bacteria formulation (wP) previously used since the 1950s. To understand this effect, we compared antibody and T cell responses to a booster immunization in subjects who received either the wP or aP vaccine as their initial priming dose in childhood. Antibody responses in wP- and aP-primed donors were similar. Magnitude of T cell responses was higher in aP-primed individuals. Epitope mapping revealed the T cell immunodominance patterns were similar for both vaccines. Further comparison of the ratios of IFNγ and IL-5 revealed that IFNγ strongly dominates the T cell response in wP-primed donors, while IL-5 is dominant in aP primed individuals. Surprisingly, this differential pattern is maintained after booster vaccination, at times from eighteen years to several decades after the original aP/wP priming. These findings suggest that childhood aP versus wP vaccination induces functionally different T cell responses to pertussis that become fixed and are unchanged even upon boosting.

show abstract

“…Although the goal of vaccination is to establish durable, lifelong immunity, it has become clear that for a number of infectious diseases, vaccine-induced host protective immunity wanes over time (4)(5)(6)(7)(8)(9)(10). Participants in an NIAID-sponsored workshop, "Waning Immunity and Microbial Vaccines," reviewed research on six representative vaccines and assessed the issue of waning immunity and possible approaches to generate long-term protection.…”

mentioning

confidence: 99%

Waning Immunity and Microbial Vaccines—Workshop of the National Institute of Allergy and Infectious Diseases

Plotkin

Edwards

et al. 2017

Clin Vaccine Immunol

View full text Add to dashboard Cite

Since the middle of the 20th century, vaccines have made a significant public health impact by controlling infectious diseases globally. Although long-term protection has been achieved with some vaccines, immunity wanes over time with others, resulting in outbreaks or epidemics of infectious diseases. Long-term protection against infectious agents that have a complex life cycle and antigenic variation remains a key challenge. Novel strategies to characterize the short-and long-term immune responses to vaccines and to induce immune responses that mimic natural infection have recently emerged. New technologies and approaches in vaccinology, such as adjuvants, delivery systems, and antigen formulations, have the potential to elicit more durable protection and fewer adverse reactions; together with in vitro systems, these technologies have the capacity to model and accelerate vaccine development. The National Institute of Allergy and Infectious Diseases (NIAID) held a workshop on 19 September 2016 that focused on waning immunity to selected vaccines (for Bordetella pertussis, Salmonella enterica serovar Typhi, Neisseria meningitidis, influenza, mumps, and malaria), with an emphasis on identifying knowledge gaps, future research needs, and how this information can inform development of more effective vaccines for infectious diseases.

show abstract

Waning and aging of cellular immunity toB. pertussis

Cited by 27 publications

References 98 publications

Th1/Th17 polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters

Th1/Th17 polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters

Th1 versus Th2 T cell polarization by whole-cell and acellular childhood pertussis vaccines persists upon re-immunization in adolescence and adulthood

Waning Immunity and Microbial Vaccines—Workshop of the National Institute of Allergy and Infectious Diseases

Contact Info

Product

Resources

About