Walnut leaf extract inhibits PTP1B and enhances glucose-uptake in vitro

Pitschmann, Anna; Zehl, Martin; Atanasov, Atanas G.; Dirsch, Verena M.; Heiss, Elke H.; Glasl, Sabine

doi:10.1016/j.jep.2014.02.017

Cited by 33 publications

(32 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Leaf methanolic extracts obtained from this tree were shown to inhibit the activity of protein tyrosine phosphatase 1B (PTP1B), which is in charge of the negative regulation of insulin-signaling pathway [37]. Furthermore, chlorogenic acid has been observed to enhance glucose uptake in myocytes by inhibition of PTP1B [38]. Moreover, in diabetic rats (but not in the normoglycemic animals), quercetin has been shown to significantly increase the activity of hepatic glucokinase, which mediates the conversion of glucose into glucose-6-phosphate (G6P) and is involved in insulin functional pathway [39].…”

Section: Mechanisms Of Action Of Momentioning

confidence: 99%

Effects of Moringa oleifera on Glycaemia and Insulin Levels: A Review of Animal and Human Studies

2019

View full text Add to dashboard Cite

Diabetes and related neurological complications are serious worldwide public health problems. The increasing number of affected individuals make it necessary to implement novel nutritional and therapeutic interventions. The tree Moringa oleifera (MO) has been used as a food source and for traditional medicine purposes due to possible antihyperglycemic, antioxidant, anti-inflammatory, and lipid regulating properties. These properties may be explained by the presence of numerous phytochemicals in the leaves, fruits, roots and, oil of the tree. The evidence for acute antihyperglycemic effects of MO extract on diabetic animal models seems to be robust, but more chronic and long-term studies are needed. In contrast, the hypoglycemic effects of MO on humans are not as clear. The scarce number of human studies, together with a diverse range of methodologies and MO doses, may explain this. In addition, evidence regarding changes in insulin levels due to MO intervention is ambiguous, both in animal and human studies. Therefore, more structured studies are needed to clarify if MO has an effect on insulin levels or activity.

show abstract

Section: Mechanisms Of Action Of Momentioning

confidence: 99%

Effects of Moringa oleifera on Glycaemia and Insulin Levels: A Review of Animal and Human Studies

2019

View full text Add to dashboard Cite

show abstract

“…Estos resultados se podrían explicar por lo hallado en otros estudios similares (42) en miembros de la familia Juglans, donde se encontró capacidad de disminución de la captación de glucosa e inhibición de la protein-tirosina fosfatasa 1B (PTP1B).…”

Section: Resultsunclassified

“…No se encontraron estudios previos relacionados a la actividad hipoglicemiante de esta especie en animales de experimentación; sin embargo, se han realizado ensayos clínicos (41,42) en seres humanos con extractos de Juglans regia donde se ha encontrado actividad hipoglicemiante a concentraciones de 100 mg. con diferencias signiicativas en comparación al tratamiento convencional (glibenclamida y metformina), a diferencia del presente estudio, donde la dosis que presentó una mejor correlación al momento de comparar las diferencias antes y después de la administración, fue la de 250 mg/kg.…”

Section: Resultsunclassified

Toxicidad, actividad antioxidante in vitro e hipoglicemiante in vitro e in vivo del extracto acuoso de Juglans neotropica Diels (nogal peruano)

Aranda-Ventura¹,

Vallejo²,

Sotero³

et al. 2017

Rev. per. med. integr.

View full text Add to dashboard Cite

Objetivos: Evaluar la toxicidad, actividad antioxidante e hipoglicemiante del extracto acuoso liofilizado de Juglans neotropica Diels “nogal peruano”. Materiales y Métodos: Se realizó una caracterización fitoquímica mediante cromatografía de gases y espectrometría de masas. La toxicidad fue medida en larvas de Artemia salina. La actividad antioxidante fue medida usando el test de 2,2-difenil-1-picrilhidrazil (DPPH). La actividad hipoglicemiante in vitro fue evaluada mediante la prueba de inhibición de α-glucosidasa; e in vivo mediante el uso de 36 ratas albinas divididas en cuatro grupos de acuerdo a la dosis suministrada (Glibenclamida 10 mg/kg, J.neotropica 100 mg/kg, 250 mg/kg y 500 mg/kg).Resultados: dentro de los fitoconstituyentes se encontraron compuestos piranos, carbohidratos y fenoles.Con respecto a la letalidad, se encontró una CL50 de 3108 ug/mL. La mayor actividad antioxidante con el test de DPPH fue encontrada en la concentración de 20 mg/mL (86.68 ± 0.71%) con una IC50: (3.8 ± 0.31 mg/mL). La concentración de 2000 ug/mL y 1750 ug/mL mostraron la mejor actividad inhibitoria de la α-glucosidasa (IC50: 399.39 ug/mL). Se observó que había diferencia significativa (p<0.05) al comparar el grupo glibenclamida con la dosis de Juglans neotropica D 250 mg/kg (CIC: 0.95; IC95%: 0.59-0.99) y 500 mg/kg. Conclusiones: El extracto acuoso liofilizado de Juglans neotropica Diels “nogal peruano” no es tóxico, tiene buena capacidad antioxidante y actividad hipoglicemiante in vitro e in vivo a unas concentraciones de 2000 ug/mL y 250 mg/kg, respectivamente.

show abstract

“…In Mediterranean and Asiatic countries, air-dried leaves of Juglans regia have been employed to treat diabetic symptoms (Hosseini et al, 2014a), and the potential of walnut leaves to ameliorate hyperglycaemia in humans has been investigated by both in vitro and in vivo. The methanolic extract obtained from walnut leaves has been proven to enhance glucose uptake in myocytes by inhibition of PTP1B, whereas it did not exert any effect on PPARγ (Pitschmann et al, 2014). A human trial designed to determine the hypoglycaemic effects of J. regia leaf aqueous extract in type II diabetic patients has been recently conducted.…”

Section: Introductionmentioning

confidence: 99%

“…The mechanisms of action underlying the antihyperglycaemic effect of the walnut leaf extracts were investigated by in vitro studies. Hence, the inhibition of α-amylase (Rahimzadeh, Jahanshahi, Moein, & Moein, 2014), the inhibition of glycation and oxidation reactions (Ahmad, Khan, & Wahid, 2012), and the inhibition of PTP1B have been suggested (Pitschmann et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Bioassay-guided identification of the antihyperglycaemic constituents of walnut ( Juglans regia ) leaves

Forino

Stiuso

Lama

et al. 2016

Journal of Functional Foods

View full text Add to dashboard Cite

Walnut leaf extract inhibits PTP1B and enhances glucose-uptake in vitro

Cited by 33 publications

References 13 publications

Effects of Moringa oleifera on Glycaemia and Insulin Levels: A Review of Animal and Human Studies

Effects of Moringa oleifera on Glycaemia and Insulin Levels: A Review of Animal and Human Studies

Toxicidad, actividad antioxidante in vitro e hipoglicemiante in vitro e in vivo del extracto acuoso de Juglans neotropica Diels (nogal peruano)

Bioassay-guided identification of the antihyperglycaemic constituents of walnut ( Juglans regia ) leaves

Contact Info

Product

Resources

About