This study was designed to examine the nephroprotective effect of Bromelain against oxidative stress caused by Tyloxopol-induced hyperlipidemia in rats. Accordingly, rats (n=6) were evaluated under three groups. I: Control (C) Group: The group that did not make any application and only received distilled water; II: Tyloxapol (TX) Group: The group that received Tylaxopol (400 mg/kg, i.p); III: Tyloxapol + Bromelain (TX+BR) Group: Group that received of Bromelain (250 mg/kg, o.d) for 18 days. Results: As a result of Tyloxapol application, there was a decrease in the levels of oxidative stress parameters SOD and CAT, while an increase in MDA levels was observed. In addition, histopathological variations were detected in kidney sections. In contrast, lipid peroxidation was reduced in rats given bromelain alone in the study, and most of the parameters studied were improved. As a result, it is thought that bromelain may be a potential agent with a protective effect for further studies.