Walnut Allergy Across Europe: Distribution of Allergen Sensitization Patterns and Prediction of Severity

Lyons, Sarah; Datema, Mareen R.; Le, Thuy‐My; Asero, Riccardo; Barreales, Laura; Bělohlávková, Simona; Blay, F. De; Clausen, Michael; Dubakiene, R.; Fernández‐Pérez, Cristina; Fritsche, Philipp; Gíslason, Davíð; Hoffmann‐Sommergruber, Karin; Jędrzejczak-Czechowicz, Monika; Jongejan, Laurian; Kowalski, Marek L.; Kralimarkova, Tanya; Lidholm, Jonas; Papadopoulos, Nikolaos G.; Pontoppidan, Bo; Popov, Todor A.; Prado, Náyade del; Purohit, Ashok; Reig, Isabel; Seneviratne, Suranjith L.; Sinaniotis, A.; Vassilopoulou, Εmilia; Versteeg, Serge A.; Vieths, Stefan; Zwinderman, Aeilko H.; Welsing, Paco; Mills, E.N. Clare; Ballmer‐Weber, Barbara; Knulst, André C.; Fernández‐Rivas, Montserrat; Ree, Ronald van

doi:10.1016/j.jaip.2020.08.051

Cited by 24 publications

(35 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, as for other major tree nuts, walnut ingestion may pose a health risk due to the possibility of inducing hypersensitivity in sensitized/allergic individuals. In fact, one of the most important nut allergies in Europe is linked to the consumption of walnut [ 171 ]. Since 1993, walnut and other tree nuts have been defined as one of the 8 groups responsible for almost 90% of human food allergies.…”

Section: Overview Of Nuts and Peanut Allergens Composition And Analyt...mentioning

confidence: 99%

Tree Nuts and Peanuts as a Source of Beneficial Compounds and a Threat for Allergic Consumers: Overview on Methods for Their Detection in Complex Food Products

Luparelli

Losito

Angelis

et al. 2022

Foods

View full text Add to dashboard Cite

Consumption of tree nuts and peanuts has considerably increased over the last decades due to their nutritional composition and the content of beneficial compounds. On the other hand, such widespread consumption worldwide has also generated a growing incidence of allergy in the sensitive population. Allergy to nuts and peanuts represents a global relevant problem, especially due to the risk of the ingestion of hidden allergens as a result of cross-contamination between production lines at industrial level occurring during food manufacturing. The present review provides insights on peanuts, almonds, and four nut allergens—namely hazelnuts, walnuts, cashew, and pistachios—that are likely to cross-contaminate different food commodities. The paper aims at covering both the biochemical aspect linked to the identified allergenic proteins for each allergen category and the different methodological approaches developed for allergens detection and identification. Attention has been also paid to mass spectrometry methods and to current efforts of the scientific community to identify a harmonized approach for allergens quantification through the detection of allergen markers.

show abstract

Section: Overview Of Nuts and Peanut Allergens Composition And Analyt...mentioning

confidence: 99%

Tree Nuts and Peanuts as a Source of Beneficial Compounds and a Threat for Allergic Consumers: Overview on Methods for Their Detection in Complex Food Products

Luparelli

Losito

Angelis

et al. 2022

Foods

View full text Add to dashboard Cite

show abstract

“…Peanut and tree nuts are reportedly the most common causes of food-induced anaphylaxis ( 1 ). In recent papers on hazelnut allergy ( 20 ) and walnut allergy ( 21 ), we set out to develop prediction models in which a patient's demographic and clinical background is combined with results from routine extract-based tests and from component-resolved diagnostics (CRD). For both tree nuts, models combining clinical background information with measures of IgE-sensitization were shown to improve the accuracy of predicting severe reactions significantly compared with clinical variables, IgE to extract, or IgE to allergen components alone.…”

Section: Introductionmentioning

confidence: 99%

Estimating the Risk of Severe Peanut Allergy Using Clinical Background and IgE Sensitization Profiles

Datema¹,

Lyons²,

Fernández‐Rivas³

et al. 2021

Front.Allergy

Self Cite

View full text Add to dashboard Cite

Background: It is not well-understood why symptom severity varies between patients with peanut allergy (PA).Objective: To gain insight into the clinical profile of subjects with mild-to-moderate and severe PA, and investigate individual and collective predictive accuracy of clinical background and IgE to peanut extract and components for PA severity.Methods: Data on demographics, patient history and sensitization at extract and component level of 393 patients with probable PA (symptoms ≤ 2 h + IgE sensitization) from 12 EuroPrevall centers were analyzed. Univariable and penalized multivariable regression analyses were used to evaluate risk factors and biomarkers for severity.Results: Female sex, age at onset of PA, symptoms elicited by skin contact with peanut, family atopy, atopic dermatitis, house dust mite and latex allergy were independently associated with severe PA; birch pollen allergy with mild-to-moderate PA. The cross-validated AUC of all clinical background determinants combined (0.74) was significantly larger than the AUC of tests for sensitization to extract (0.63) or peanut components (0.54–0.64). Although larger skin prick test wheal size, and higher IgE to peanut extract, Ara h 1 and Ara h 2/6, were associated with severe PA, and higher IgE to Ara h 8 with mild-to-moderate PA, addition of these measurements of sensitization to the clinical background model did not significantly improve the AUC.Conclusions: Models combining clinical characteristics and IgE sensitization patterns can help establish the risk of severe reactions for peanut allergic patients, but clinical background determinants are most valuable for predicting severity of probable PA in an individual patient.

show abstract

“…To our knowledge, this is the first Italian study to provide a comprehensive characterization of children with nut allergies [15], although a Turkish study has recently been published on the same topic [22]. Indeed, most of the studies about nut allergies have focused on a single type of nut, especially peanut, walnut, or hazelnut, or summarized the main characteristics of nut allergies without making a distinction between the various kinds of nuts [11,[23][24][25][26]. Conversely, we retrospectively analyzed the demographic, clinical, and allergological characteristics of Italian children with nut allergies and compared them.…”

Section: Discussionmentioning

confidence: 99%

Nut Allergy: Clinical and Allergological Features in Italian Children

et al. 2021

View full text Add to dashboard Cite

Background: Nut allergies are an increasingly frequent health issue in the pediatric population. Tree nuts (TN) and peanuts are the second cause of food anaphylaxis in Italy. Unfortunately, knowledge of the clinical characteristics of a TN allergy in Italian children is limited. Our study aimed to identify the clinical and allergological characteristics of Italian children with a nut allergy (TN and peanut). Methods: A retrospective observational analysis was performed on the clinical charts of children with a history of nut reaction referred to the allergy unit of the hospital from 2015 to 2019. The studied population was represented by children with a confirmed nut allergy based on positive prick by prick and/or serum-specific IgE to nut plus a positive nut oral food challenge. Demographic, clinical, and allergological features were studied and compared among different nuts. Results: In total, 318 clinical charts were reviewed. Nut allergy was confirmed in 113 patients. Most patients (85/113, 75%) had a familial history of allergy and/or a concomitant allergic disorder (77/113, 68%). Hazelnut and walnut were the more common culprit nuts observed in allergic children. Anaphylaxis was the first clinical manifestation of nut allergy in a high percentage of children (54/113, 48%). The mean age of the first nut reaction was statistically higher with pine nuts. Over 75% of children reported a single nut reaction. During the OFCs, the signs and symptoms involved mainly the gastrointestinal system (82/113, 73%) and resolved spontaneously in most cases. Severe reactions were not frequent (22/113, 19%). Conclusion: To our knowledge, this is the first Italian study that provided a comprehensive characterization of children with a nut allergy. These results are important for clinicians treating children with a nut allergy.

show abstract

Walnut Allergy Across Europe: Distribution of Allergen Sensitization Patterns and Prediction of Severity

Cited by 24 publications

References 30 publications

Tree Nuts and Peanuts as a Source of Beneficial Compounds and a Threat for Allergic Consumers: Overview on Methods for Their Detection in Complex Food Products

Tree Nuts and Peanuts as a Source of Beneficial Compounds and a Threat for Allergic Consumers: Overview on Methods for Their Detection in Complex Food Products

Estimating the Risk of Severe Peanut Allergy Using Clinical Background and IgE Sensitization Profiles

Nut Allergy: Clinical and Allergological Features in Italian Children

Contact Info

Product

Resources

About