Wall shear stress in hypertensive patients is associated with carotid vascular deformation assessed by speckle tracking strain imaging

Yang, Joung Wook; Cho, Kyoung Im; Kim, Jehun; Kim, Soo Young; Kim, Cheol Su; You, Ga In; Lee, Jin Young; Choi, Seon Yoon; Lee, Sea Won; Kim, Hyun Soo; Heo, Jung Ho; Joon, Tae; Lee, Jae Woo

doi:10.1186/2056-5909-20-10

Cited by 31 publications

(21 citation statements)

References 36 publications

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“…Because of the lack of techniques to assess WSS in vivo, WSS has been calculated according to Poiseuille's law using recorded velocity profiles and whole-blood viscosity in large arteries 10) . Our previous study suggested that local shear stress measured by US was associated with carotid vascular deformation, which could be an underlying mechanism for the progression of atherosclerosis 29) . Because high WSS is atheroprotective and low WSS may be atherogenic, the atheroprotective effect may be maximal above a given value, and classic risk factors would be required to cause arterial damage in these cases.…”

Section: Conflicts Of Interestmentioning

confidence: 96%

Low Carotid Artery Wall Shear Stress is Associated with Significant Coronary Artery Disease in Patients with Chest Pain

Cho

Kim

et al. 2016

J Atheroscler Thromb

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Aim:To investigate the relationships among carotid wall shear stress (WSS), carotid intima-media thickness (IMT), and total plaque area (TPA) using ultrasound (US) in the common carotid artery (CCA) in patients with suspected coronary artery disease (CAD). Methods: Carotid artery US was performed in 950 patients with suspected CAD, and mean IMT, TPA, and hemodynamic parameters of CCA, including peak and mean WSS, were measured. We

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Section: Conflicts Of Interestmentioning

confidence: 96%

Low Carotid Artery Wall Shear Stress is Associated with Significant Coronary Artery Disease in Patients with Chest Pain

Cho

Kim

et al. 2016

J Atheroscler Thromb

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“…Hence, such an approach may be highly promising for the production of theranostic nanoparticles with a good safety profile. Unfortunately, an increase in blood shear stress is often also a result of other CVDs, such as hypertension and aneurysms 108 , 109 , thus the applicability of shear responsive systems may be limited in patients suffering such diseases. The double-shell design employed here also increases the complexity of fabrication and thus reduces the cost-effectiveness, though the development of a more simplistic design may negate this issue.…”

Section: Responsive Theranostic Nanocarriersmentioning

confidence: 99%

Theranostic nanoparticles for the management of thrombosis

Russell¹,

Hagemeyer²,

Esser³

et al. 2022

Theranostics

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Acute thrombosis and thromboembolisms are one of the leading causes of mortality and morbidity in both developed and developing countries, placing a huge burden on health and economic systems. Early diagnosis is critical but currently limited in accuracy and hampered by a narrow time frame, where the short therapeutic window also severely restricts treatment options. Additionally, clinically used antithrombotics and thrombolytics suffer from severe side effects and are limited in efficacy by a short half-life and susceptibility to degradation. The use of systems containing both diagnostic and therapeutic moieties, known as theranostics, can potentially improve patient outcomes by increasing the precision and efficacy of diagnosis and treatment, enabling personalised and precision medicine. Leveraging nanomedicine may further improve treatment by improving the system's pharmacokinetic properties including controlled drug delivery. This review provides an overview of the development of such theranostic nanoparticle systems, with a focus on approaches that may be utilised to usher this field towards clinical use.

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“…An altered WSS profile also appears to correlate with local elastic changes in the vasculature [ 8 ]. As hemodynamic parameters like the WSS play a key role in local plaque development [ 8 ], and as ultrasound-measurements indicate a possible link between higher PWV and lowered WSS [ 9 ], the simultaneous measurement of these two parameters is of great interest. In comparison to ultrasound, cardiovascular magnetic resonance (CMR) provides better tissue contrast and higher dimensional flow measurements.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous measurements of 3D wall shear stress and pulse wave velocity in the murine aortic arch

Winter

Andelovic

Kampf

et al. 2021

Journal of Cardiovascular Magnetic Resonance

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Purpose Wall shear stress (WSS) and pulse wave velocity (PWV) are important parameters to characterize blood flow in the vessel wall. Their quantification with flow-sensitive phase-contrast (PC) cardiovascular magnetic resonance (CMR), however, is time-consuming. Furthermore, the measurement of WSS requires high spatial resolution, whereas high temporal resolution is necessary for PWV measurements. For these reasons, PWV and WSS are challenging to measure in one CMR session, making it difficult to directly compare these parameters. By using a retrospective approach with a flexible reconstruction framework, we here aimed to simultaneously assess both PWV and WSS in the murine aortic arch from the same 4D flow measurement. Methods Flow was measured in the aortic arch of 18-week-old wildtype (n = 5) and ApoE−/− mice (n = 5) with a self-navigated radial 4D-PC-CMR sequence. Retrospective data analysis was used to reconstruct the same dataset either at low spatial and high temporal resolution (PWV analysis) or high spatial and low temporal resolution (WSS analysis). To assess WSS, the aortic lumen was labeled by semi-automatically segmenting the reconstruction with high spatial resolution. WSS was determined from the spatial velocity gradients at the lumen surface. For calculation of the PWV, segmentation data was interpolated along the temporal dimension. Subsequently, PWV was quantified from the through-plane flow data using the multiple-points transit-time method. Reconstructions with varying frame rates and spatial resolutions were performed to investigate the influence of spatiotemporal resolution on the PWV and WSS quantification. Results 4D flow measurements were conducted in an acquisition time of only 35 min. Increased peak flow and peak WSS values and lower errors in PWV estimation were observed in the reconstructions with high temporal resolution. Aortic PWV was significantly increased in ApoE−/− mice compared to the control group (1.7 ± 0.2 versus 2.6 ± 0.2 m/s, p < 0.001). Mean WSS magnitude values averaged over the aortic arch were (1.17 ± 0.07) N/m2 in wildtype mice and (1.27 ± 0.10) N/m2 in ApoE−/− mice. Conclusion The post processing algorithm using the flexible reconstruction framework developed in this study permitted quantification of global PWV and 3D-WSS in a single acquisition. The possibility to assess both parameters in only 35 min will markedly improve the analyses and information content of in vivo measurements.

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Wall shear stress in hypertensive patients is associated with carotid vascular deformation assessed by speckle tracking strain imaging

Cited by 31 publications

References 36 publications

Low Carotid Artery Wall Shear Stress is Associated with Significant Coronary Artery Disease in Patients with Chest Pain

Low Carotid Artery Wall Shear Stress is Associated with Significant Coronary Artery Disease in Patients with Chest Pain

Theranostic nanoparticles for the management of thrombosis

Simultaneous measurements of 3D wall shear stress and pulse wave velocity in the murine aortic arch

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