Wall-Less Flow Phantoms With Tortuous Vascular Geometries: Design Principles and a Patient-Specific Model Fabrication Example

Ho, Chung Kit; Chee, Adrian J. Y.; Yiu, Billy Y. S.; Tsang, Arthur; Chow, K. W.; Yu, Alfred C. H.

doi:10.1109/tuffc.2016.2636129

Cited by 33 publications

(46 citation statements)

References 54 publications

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“…The flow phantom was fabricated based on investment casting principles according to the protocol reported in our previous work . In this study, a PVA‐based wall‐less flow phantom with a 15 mm diameter flow channel across a tissue mimicking slab was fabricated.…”

Section: Methodsmentioning

confidence: 99%

High frame rate doppler ultrasound bandwidth imaging for flow instability mapping

Yiu

Chee

Tang³

et al. 2019

Medical Physics

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Purpose Flow instability has been shown to contribute to the risk of future cardiovascular and cerebrovascular events. Nonetheless, it is challenging to noninvasively detect and identify flow instability in blood vessels. Here, we present a new framework called Doppler ultrasound bandwidth imaging ( DUBI ) that uses high‐frame‐rate ultrasound and Doppler bandwidth analysis principles to assess flow instability within an image view. Methods Doppler ultrasound bandwidth imaging seeks to estimate the instantaneous Doppler bandwidth based on autoregressive modeling at every pixel position of data frames acquired from high‐frame‐rate plane wave pulsing. This new framework is founded upon the principle that flow instability naturally gives rise to a wide range of flow velocities over a sample volume, and such velocity range in turn yields a larger Doppler bandwidth estimate. The ability for DUBI to map unstable flow was first tested over a range of fluid flow conditions (ranging from laminar to turbulent) with a nozzle‐flow phantom. As a further demonstration, DUBI was applied to assess flow instability in healthy and stenosed carotid bifurcation phantoms. Results Nozzle‐flow phantom results showed that DUBI can effectively detect and visualize the difference in Doppler bandwidth magnitude (increased from 2.1 to 5.2 kH z) at stable and unstable flow regions in an image view. Receiver operating characteristic analysis also showed that DUBI can achieve optimal sensitivity and specificity of 0.72 and 0.83, respectively. In the carotid phantom experiments, differences were observed in the spatiotemporal dynamics of Doppler bandwidth over a cardiac cycle. Specifically, as the degree of stenosis increased (from 50% to 75%), DUBI showed an increase in Doppler bandwidth magnitude from 1.4 kH z in the healthy bifurcation to 7.7 kH z at the jet tail located downstream from a 75% stenosis site, thereby indicating flow perturbation in the stenosed bifurcations. Conclusion DUBI can detect unstable flow. This new technique can provide useful hemodynamic information that may aid clinical diagnosis of atherosclerosis.

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Section: Methodsmentioning

confidence: 99%

High frame rate doppler ultrasound bandwidth imaging for flow instability mapping

Yiu

Chee

Tang³

et al. 2019

Medical Physics

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“…With adding 5-μm-diameter of Orgasol ™ as a scattering material, the physical and acoustical properties matched the real human blood cells. [ 66 ]…”

Section: T Ypes Of S Uspension mentioning

confidence: 99%

A review of suspension-Scattered particles used in blood-mimicking fluid for doppler ultrasound imaging

et al. 2018

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Doppler ultrasound imaging system description and calibration need blood-mimicking fluids (BMFs) for the test target of medical ultrasound diagnostic tools, with known interior features and acoustic and physical properties of this fluid (BMF). Physical and acoustical properties determined in the International Electrotechnical Commission (IEC) standard are specified as constant values, the materials used in the BMF preparation should have values similar to the IEC standard values. However, BMF is ready-made commercially from a field of medical usage, which may not be appropriate in the layout of ultrasound system or for an estimate of novel imaging mechanism. It is often eligible to have the capability to make sound properties and mimic blood arrangement for specific applications. In this review, sufficient BMF materials, liquids, and measures are described which have been generated by utilizing diverse operation mechanism and materials that have sculptured a range of biological systems.

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“…Clear images of small vessels can also be obtained by using eigenvalue filters to suppress clutter signals (Yu and Lovstakken 2010;Song et al 2017a and2017b). In addition, blood flow in complicated structures, such as the bifurcation of an artery can be measured (Yiu et al 2014;Chee et al 2016), as can urinary flow (Ho et al 2017;Ishii et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Ultrasound Sub-pixel Motion-tracking Method with Out-of-plane Motion Detection for Precise Vascular Imaging

Yoshikawa

Yamamoto

Tanaka

et al. 2020

Ultrasound in Medicine & Biology

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Ultrasound vascularity imaging provides important information for differential diagnosis of tumors. Peak-hold (PH) is a useful technique for precisely imaging small vessels by selecting a maximum brightness in each pixel through the frames obtained sequentially. To use PH successfully one needs motion compensation to reduce image blur, but out-of-plane motion cannot be avoided. To address this problem, we developed a sub-pixel motion-tracking method with out-of-plane motion detection (OPMD). It is a combination of the sum of the absolute differences (SAD) method and the Kanade-Lucas-Tomasi method and can be accurately applied to various motions. The value from OPMD (g) is defined as a statistical value obtained from the distribution of residual values in the SAD procedure with the obtained frames. The value is ideally 0, and the frames having large g are removed from the PH procedure. The accuracy of the proposed tracking method was found by a simulation study to be approximately 20 mm. We also found, through a phantom experiment, that the value of g sensitively increased enough to detect out-of-plane motion. Most important, g begins to increase before tracking errors occur. This suggests that OPMD can be used to predict tracking errors and effectively remove frames from the PH procedure. An in vivo experiment with a rabbit showed that the PH image obtained with motion tracking clearly revealed peripheral vessels that were blurred in the PH image obtained without motion tracking. We also found that the image quality becomes better when OPMD was used to remove frames including out-of-plane motion.

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Wall-Less Flow Phantoms With Tortuous Vascular Geometries: Design Principles and a Patient-Specific Model Fabrication Example

Cited by 33 publications

References 54 publications

High frame rate doppler ultrasound bandwidth imaging for flow instability mapping

High frame rate doppler ultrasound bandwidth imaging for flow instability mapping

A review of suspension-Scattered particles used in blood-mimicking fluid for doppler ultrasound imaging

Ultrasound Sub-pixel Motion-tracking Method with Out-of-plane Motion Detection for Precise Vascular Imaging

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