Wall-lesion development in gaps: The role of the adhesive bonding material

Montagner, Anelise Fernandes; Kuper, N.K.; Opdam, N.J.M.; Bronkhorst, Ewald M.; Cenci, Maximiliano Sérgio; Huysmans, M.C.D.N.J.M.

doi:10.1016/j.jdent.2015.04.007

Cited by 21 publications

(15 citation statements)

References 18 publications

(25 reference statements)

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“…The presence of bonding material could act as a retention factor for biofilm growth, and this could explain the increase of secondary caries progression in this condition. Although the thickness of the biofilm was not measured, results from a recent in situ study performed by our group corroborate this [Montagner et al, 2015].…”

Section: Doi: 101159/000490195supporting

confidence: 59%

“…It has been demonstrated that CHX used as an MMP inhibitor in demineralized dentin after etching and prior adhesive procedures improves the hybrid layer integrity and bond strength between the tooth and the composite resin [Carrilho et al, 2007b;Montagner et al, 2015], but these results have not been confirmed in recent clinical trials [Gostemeyer and Schwendicke, 2016;Favetti et al, 2017]. It is speculated that MMPs remain inhibited for as long as CHX remains bonded to the collagenous matrix, but there is still no consensus about how long a CHX solution will retain its MMP inhibitory activity in a dentin substrate [Carrilho et al, 2007b].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Chlorhexidine, a Matrix Metalloproteinase Inhibitor and the Development of Secondary Caries Wall Lesions in a Microcosm Biofilm Model

Maske¹,

Kuper²,

Cenci

et al. 2018

Caries Res

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This study investigated the role of a matrix metalloproteinase (MMP) inhibitor (CHX 2%) in the development of secondary caries wall lesions in different interface conditions with small (run 1) and wider gaps (run 2). Dentin discs were restored and pretreated with or without CHX 2%. In run 1, interfaces were made with gaps of 30, 60, or 90 µm. Interfaces with composite placed directly onto the dentin were either bonded (Adper Single Bond 2) or not bonded. In run 2, interfaces were made with gaps of 100 µm, with or without adhesive on the composite side (CLEARFIL SE Bond). Interfaces were either bonded or not bonded, as in run 1. Microcosm biofilms were grown on dentin-composite samples for 14 days. Caries lesion outcomes were analyzed by transversal wavelength-independent microradiography at 3 locations: the outer surface, and the interface wall at a distance of 200 and 500 µm from the gap entrance. Linear regression analyses showed that pretreatment with MMP inhibitor did not influence progression of the wall lesion at any location (p ≥ 0.218). Interfaces with intentional gaps showed positive and significant effect on the wall lesion progression at 200 µm from the gap entrance (p ≤ 0.005). A small trend of increase in wall lesion development was observed at the 200-µm location when bonding was present on the composite side. In conclusion, the dentin pretreatment with CHX 2% was not able to slow down the development of secondary caries wall lesions in small and wide gaps in this biofilm model.

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Section: Doi: 101159/000490195supporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Chlorhexidine, a Matrix Metalloproteinase Inhibitor and the Development of Secondary Caries Wall Lesions in a Microcosm Biofilm Model

Maske¹,

Kuper²,

Cenci

et al. 2018

Caries Res

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show abstract

“…However, this may raise some doubts on the comparability of samples placed in the upper and lower slots. Although we estimate this to be unlikely, also based on a separate analysis of composite samples in the upper and lower slots [Montagner et al, 2015], we cannot be completely certain. In subsequent studies, the sample distribution should also be randomized for upper and lower slot position.…”

Section: Discussionmentioning

confidence: 83%

Secondary Caries Development in in situ<b> </b>Gaps next to Composite and Amalgam

et al. 2015

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This in situ study investigated the secondary caries development in dentin in gaps next to composite and amalgam. For 21 days, 14 volunteers wore a modified occlusal splint containing human dentin samples with an average gap of 215 µm (SD = 55 µm) restored with three different materials: Filtek Supreme composite, Clearfil AP-X composite and Tytin amalgam. Eight times a day, the splint with samples was dipped in a 20% sucrose solution for 10 min. Before and after caries development, specimens were imaged with transversal wavelength independent microradiography, and lesion depth (LD) and mineral loss (ML) were calculated. The LD and ML of the three restoration materials were compared within patients using paired t tests (α = 5%). In total 38 composite samples (Filtek n = 19 and AP-X n = 19) and 19 amalgam samples could be used for data analysis. AP-X composite presented the highest mean values of LD and ML of the three restorative materials. Amalgam showed statistically significantly less ML (Δ = 452 µm × vol%) than the combined composite materials (p = 0.036). When comparing amalgam to the separate composite materials, only AP-X composite showed higher ML (Δ = 515 µm × vol%) than amalgam (p = 0.034). Analysis of LD showed the same trends, but these were not statistically significant. In conclusion, amalgam showed reduced secondary caries progression in dentin in gaps compared to composite materials tested in this in situ model.

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“…The presence of these components in Clearfil SE Protect has been reported to prevent long-term deterioration of the adhesive interface to a greater extent than Clearfil SE Bond [20,32,33]. Recent studies have revealed Clearfil SE Protect inhibits mineral loss from the walls of the lesion [34]. Despite the excellent results described for this adhesive system, its performance can potentially be compromised if the air-drying is incomplete.…”

Section: Discussionmentioning

confidence: 99%

Clinical observation of the tooth surface during air-drying of self-etching primer under 3D video microscope

2016

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Wall-lesion development in gaps: The role of the adhesive bonding material

Abstract: The presence and location of an adhesive bonding material in the composite-dentin gaps plays a role on the wall caries lesion development.

Cited by 21 publications

References 18 publications

Chlorhexidine, a Matrix Metalloproteinase Inhibitor and the Development of Secondary Caries Wall Lesions in a Microcosm Biofilm Model

Chlorhexidine, a Matrix Metalloproteinase Inhibitor and the Development of Secondary Caries Wall Lesions in a Microcosm Biofilm Model

Secondary Caries Development in in situ<b> </b>Gaps next to Composite and Amalgam

Clinical observation of the tooth surface during air-drying of self-etching primer under 3D video microscope

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