Wall Irregularity Rather Than Intima-Media Thickness is Associated with Nearby Atherosclerosis

Graf, Iulia M.; Schreuder, Floris H.B.M.; Hameleers, Jeroen M.; Mess, Werner H.; Reneman, Robert S.; Hoeks, Arnold P.G.

doi:10.1016/j.ultrasmedbio.2008.12.016

Cited by 32 publications

(26 citation statements)

References 21 publications

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“…On the other hand, the mean values of AD and RD hardly vary with the stenosis degree, independent of the recording side (table 2), providing supplemental evidence that the variation is due to spatial inhomogeneities. This finding corroborates an earlier study on the same study population, which showed that the local variation in intima-media thickness rather than its absolute value is strongly related to the degree of carotid bulb stenosis [2]. …”

Section: Discussionsupporting

confidence: 92%

“…Surprisingly, the local variation of intima-media thickness of the common carotid artery (CCA) rather than its thickness is more strongly related to the degree of carotid bulb stenosis [2]. Even though the dynamics of the arterial walls are influenced by age [3], lifestyle [4] and drug therapy [5], they can be used as indicators for atherosclerotic vascular disease [6,7,8].…”

Section: Introductionmentioning

confidence: 99%

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Spatial Distension Variations Are Associated with Focal Atherosclerotic Plaques

Graf

Schreuder²,

Mess³

et al. 2009

Cerebrovasc Dis

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Background: Alterations in arterial absolute distension (AD) and relative distension (RD) in the common carotid artery (CCA), as observed by ultrasound, may relate to atherosclerotic processes in a nearby vascular segment. The main objective of the study was to establish to what extent these mechanical vascular alterations relate to carotid bulb stenosis. Methods: The AD, RD and their interrecording variation (ΔAD and ΔRD), representing the spatial inhomogeneity of AD and RD, were evaluated in 308 CCA and associated with the degree of bulb stenosis. Results: The mechanical CCA parameters were marginally correlated to the degree of ipsilateral (r = –0.14 for AD and r = –0.28 for RD) and contralateral stenosis (r = –0.21 for AD and r = –0.27 for RD). However, ΔAD (r = 0.54; p < 0.001) and ΔRD (r = 0.59; p < 0.001) were significantly correlated to ipsilateral stenosis, independent of age, gender and pulse pressure. Conclusions: The indices of CCA arterial stiffness are weakly associated with ipsilateral bulb stenosis, but their interrecording variation is a good indicator for atherosclerotic alterations in the carotid bulb. The results indicate that a focal atherosclerotic lesion is associated with modifications in the dynamic characteristics of a nearby vascular segment.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Spatial Distension Variations Are Associated with Focal Atherosclerotic Plaques

Graf

Schreuder²,

Mess³

et al. 2009

Cerebrovasc Dis

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“…Inhomogeneity of the cIMT has been associated to the individual risk of vascular events, as quantified by the Framingham Score and Framingham Vascular Score [32]. Also, structural abnormality of the cIMT was found to exhibit the strongest correlation to carotid artery stenosis [32]. In dialysis patients, spatial inhomogeneity of the common carotid artery intima-media-thickness was found to be increased compared to controls [33].…”

Section: Discussionmentioning

confidence: 99%

“…To anticipate subclinical changes of carotid wall structure before irreversible atherosclerotic plaque formation, structural changes of the intimal layer have been addressed in a few studies [6,8,22,31e33]. Inhomogeneity of the cIMT has been associated to the individual risk of vascular events, as quantified by the Framingham Score and Framingham Vascular Score [32]. Also, structural abnormality of the cIMT was found to exhibit the strongest correlation to carotid artery stenosis [32].…”

Section: Discussionmentioning

confidence: 99%

Beyond intima-media-thickness: Analysis of the carotid intima-media-roughness in a paediatric population

et al. 2016

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“…Although other measurements of the carotid artery can be used to diagnose atherosclerosis [4,5], the IMT is the most frequently used measure for cardiovascular risk assessment in clinical practice [6]. The bifurcation and the internal carotid artery (ICA) are more prone to atherosclerosis, due to stronger hemodynamic stresses in the bifurcation and branching zones.…”

Section: Introductionmentioning

confidence: 99%