Walking speed during single and dual tasks in Parkinson's disease: Which characteristics are important?

Rochester, Lynn; Nieuwboer, Alice; Baker, Katherine; Hetherington, V.; Willems, Anne‐Marie; Kwakkel, Gert; Wegen, Erwin E. H. van; Lim, Inge; Jones, Diana

doi:10.1002/mds.22219

Cited by 90 publications

(120 citation statements)

References 28 publications

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“…Disparities in testing protocols and disease duration between the samples (mean 13 years), compared to the current study (mean 6 years) may account for these observed differences (Sustakoski, Perera, VanSwearingen, Studenski, & Brach, 2015). Although similar investigations of the relationships between the Walk‐12G and performance‐based gait measures are lacking, fear of falling has been associated with slower gait speeds in healthy older adults (Maki, 1997) and people with PD (Bryant, Rintala, Hou, & Protas, 2014; Rochester et al., 2008). Additionally, Curtze et al.…”

Section: Discussionmentioning

confidence: 99%

Patient‐reported and performance‐based measures of walking in mild–moderate Parkinson's disease

et al. 2018

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BackgroundKnowledge of the relationships between patient‐reported and performance‐based walking measures in Parkinson's disease (PD) should inform clinical decision‐making. The Walk‐12G reliably captures perceived walking difficulties but has not been compared to performance‐based walking in laboratory or free‐living settings or across different groups.ObjectivesTo investigate the relationship between patient‐reported walking difficulties (Walk‐12G) and performance‐based walking in laboratory and free‐living conditions and to determine whether the Walk‐12G can distinguish between the subgroups, (i) people with/without PD and (ii) mild/moderate disease stages.MethodsForty‐seven people without and 49 people with PD (Hoehn and Yahr stage II and III) were assessed in relation to patient‐reported walking difficulties (Walk‐12G scale); spatiotemporal gait characteristics (Pace; Rhythm; Asymmetry; Variability; and Postural control) using a laboratory‐based electronic walkway; and walking behavior (mean steps/day and minutes of brisk walking/day) using accelerometers in free‐living conditions.ResultsThe Walk‐12G correlated moderately with the spatiotemporal domain step velocity (r = −0.46) and walking behavior, measured as mean steps/day (r = −0.46). Weaker correlations were observed for step length and minutes spent in brisk walking (r = −0.36 and r = −0.35, respectively). Poor correlations were observed for all other spatiotemporal domains. The Walk‐12G could distinguish between people with and without PD (Effect size, r = 0.82) and between those at mild/moderate disease stages (r = 0.34).ConclusionsPerceived walking difficulties showed weak to moderate associations with performance‐based measures of walking in mild–moderate PD. As the strongest associations were observed for step velocity and walking behavior, targeting these specific gait aspects could improve perceived walking difficulties in daily life.

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Section: Discussionmentioning

confidence: 99%

Patient‐reported and performance‐based measures of walking in mild–moderate Parkinson's disease

et al. 2018

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“…Idiopathic PD results from basal ganglia dysfunction, and as a consequence, task automaticity is reduced and cognitive resources must be drawn on to maintain performance of both tasks. Studies investigating the impact of concurrent tasks on gait in PD reveal lack of automaticity and increased cognitive demands (Rochester, Nieuwboer, Baker, Hetherington, Willems, Kwakkel, Wegen, Lim, & Jones, 2008).…”

Section: Concurrent Task Effects In Parkinson's Diseasementioning

confidence: 99%

“…Consequently, individuals with basal ganglia dysfunction will have difficulty coping with concurrent tasks, and performance deficits are often exacerbated in individuals with PD (Rochester et al, 2008). …”

Section: Concurrent Task Effects In Parkinson's Diseasementioning

confidence: 99%

“…Walking in the real world is a very complex activity that requires cognitive flexibility to meet the changing demands of the environment (Rochester et al, 2008).…”

Section: Diseasementioning

confidence: 99%

“…This creates additional challenges for individuals with basal ganglia dysfunction (i.e., PD), as substantial conscious control is needed for the walking performance, making it difficult to adapt to the changing walking environment (Rochester et al, 2008).…”

Section: Diseasementioning

confidence: 99%

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Effect of concurrent walking and interlocutor distance on conversational speech intensity and rate in Parkinson's disease

et al. 2016

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This study examined the effects of concurrent walking tasks and interlocutor distance on conversational speech production in fifteen individuals with idiopathic Parkinson's disease (PD) and fourteen age-equivalent controls. Recent studies of speech in PD have demonstrated that changes in the behavioural conditions and the environmental context can have a powerful effect on the severity of speech symptoms in PD. This investigation focused on changes in speech intensity and speech rate in response to changes in walking speed and interlocutor distance. Results suggest that the introduction of a concurrent walking task significantly increased the conversational speech intensity of both controls and individuals with PD. When compared to sitting and talking or standing and talking, current walking and talking appeared to have an energizing effect on conversational speech intensity. In addition, walking faster was associated with a significant increase in conversational speech intensity relative to normal and slow walking speeds. These results provide important new information about the effect of concurrent walking on speech motor performance and speech symptom severity in PD. The potential energizing effect of concurrent walking conditions on conversational speech intensity may be an important consideration in the assessment and treatment of individuals with low speech intensity in PD.

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Early effects of rituximab on the synovial cell infiltrate in patients with rheumatoid arthritis

Vos¹,

Thurlings²,

Wijbrandts³

et al. 2007

Arthritis & Rheumatism

164

120

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Objective. To study the specific effects of rituximab treatment on the synovium in patients with rheumatoid arthritis (RA) early after initiation of treatment.Methods. Seventeen RA patients underwent an arthroscopic synovial biopsy procedure directly before and 1 month after receiving 2 infusions of the chimeric anti-CD20 monoclonal antibody rituximab (1,000 mg on days 1 and 15; both without methylprednisolone premedication). Immunohistochemical analysis was performed to characterize the cell infiltrate. Stained tissue sections were analyzed by digital image analysis. Statistical analysis was performed using Wilcoxon's signed rank test. Conclusion. Rituximab treatment leads to a rapid and significant decrease in synovial B cell numbers, but not in all patients. Whether the variable tissue response is related to the clinical response over time remains to be clarified. Results. No significant change in the Disease

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Walking speed during single and dual tasks in Parkinson's disease: Which characteristics are important?

Cited by 90 publications

References 28 publications

Patient‐reported and performance‐based measures of walking in mild–moderate Parkinson's disease

Patient‐reported and performance‐based measures of walking in mild–moderate Parkinson's disease

Effect of concurrent walking and interlocutor distance on conversational speech intensity and rate in Parkinson's disease

Early effects of rituximab on the synovial cell infiltrate in patients with rheumatoid arthritis

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