Waldenstrom's Macroglobulinemia Presenting as a Pulmonary Mass

Major, David A.; Meltzer, Mae H.; Nedwich, Alexander; Hayes, Brian; Oaks, Wilbur W.

doi:10.1378/chest.64.6.760

Cited by 12 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding tumor infiltration to bone marrow and other organs, approximately 30% of patients experience lymphadenopathy, hepatomegaly, or splenomegaly 10 . Infiltration in the lung, kidney, stomach, or conjunctivae is also reported in some cases of WM 11,12 . Other disease manifestations are due to a rise in immunoglobulins.…”

Section: Introductionmentioning

confidence: 99%

“… 10 Infiltration in the lung, kidney, stomach, or conjunctivae is also reported in some cases of WM. 11 , 12 Other disease manifestations are due to a rise in immunoglobulins. Since these large proteins contain a high volume of carbohydrates, an aggregated form of these paraproteins can bind to water and increase osmotic pressure and blood flow resistance.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Waldenström's macroglobulinemia with necrotic extremities: A case with challenging diagnosis

Nekooghadam,

Ghadirzadeh,

Lapevandani

et al. 2023

Clinical Case Reports

View full text Add to dashboard Cite

Key Clinical MessageWaldenström's macroglobulinemia may begin with constitutional symptoms that are common in primary care settings and it is crucial for physicians to be aware of the potential complications of hyperviscosity syndrome and to employ the appropriate diagnostic methods in order to achieve better outcomes.AbstractWaldenström's macroglobulinemia (WM) refers to a type of lymphoplasmacytic lymphoma distinguished by the hyperproliferation of plasma cells, lymphocytes, and plasmacytoid lymphocytes. The disease is primarily diagnosed by increased monoclonal immunoglobulin M (IgM) levels and lymphoplasmacytic cell infiltration into the bone marrow. Individuals exhibit a high risk for hyperviscosity syndrome (HVS) as immunoglobulin levels increase. In addition to constitutional symptoms (fever, night sweats, and unintentional weight loss), clinical findings such as cytopenia, hepatosplenomegaly, and lymphadenopathy, this condition may cause hyperviscosity‐related organ failures. Here we discuss a patient with WM who presented with neurological complaints and blurry vision and developed necrosis at distal portions of his body during the 6‐month course of the disease.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Waldenström's macroglobulinemia with necrotic extremities: A case with challenging diagnosis

Nekooghadam,

Ghadirzadeh,

Lapevandani

et al. 2023

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

Pulmonary manifestations of waldenstrom macroglobulinemia

Rausch

Herion

1980

American J Hematol

View full text Add to dashboard Cite

Waldenstrom macroglobulinemia (WMG), a proliferation of malignant monoclonal IgM secreting plasmacytoid lymphocytes in lymph nodes, spleen, and marrow, usually pursues a chronic clinical course. A patient with WMG for five years who developed pulmonary tumors consisting of plasmacytoid lymphocytes prompted a review of the literature for pulmonary manifestations of WMG. Twenty-six males and 18 females, ranging in age from 33 to 84 years, have been reported with histologically proven pulmonary involvement by WMG. The x-ray findings, evident in most patients when first seen, consisted of masses (22 patients), inflitrates (31 patients), and pleural effusions (19 patients). Most patients (24) had two or more of these manifestations but only five, in addition to our patient, had isolated pulmonary nodules. Isolated pulmonary infiltrates were found in ten patients and isolated pleural effusions in only four. Symptoms at the onset of pulmonary involvement included dyspnea (54%), nonproductive cough (33%), and chest pain (7%); 15% were asymptomatic. Pulmonary manifestations, like other features of WMG, respond to alkylating agents or irradiation and do not appear to affect prognosis adversely. Pulmonary involvement should be suspected in any patient with WMG who develops an abnormal chest x-ray.

show abstract