Waldenstrom's macroglobulinemia and neuropathy

Propp, Richard P.; Means, Eugene D.; Deibel, Rudolf; Sherer, Gabriela; Barron, Kevin D.

doi:10.1212/wnl.25.10.980

Cited by 102 publications

(18 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No specific lesion of the nerve fiber has been identified in every case, and both axonal and myelin sheath abnormalities have been described. In a number of instances monoclonal immunoglobulins have been demonstrated immunohistochemically to have adhered to myelin in vivo { S , 12,17,22,23,271, to bind to myelin components or myelin itself in vitro { 11, 22), or both. Abnormal globulin has also been demonstrated in the endoneurial interstitium of one patient with immunoglobulin G, myeloma and cryoglobulinemia {251.…”

mentioning

confidence: 99%

Microangiopathy of vasa nervorum in dysglobulinemic neuropathy

Powell¹,

Rodriguez²,

Hughes³

1984

Annals of Neurology

View full text Add to dashboard Cite

Thickening of vessel walls resulting from endothelial proliferation was observed in the vasa nervorum of eleven patients with peripheral neuropathy associated with dysglobulinemia. Electron microscopy showed endothelial proliferation accompanied by abnormal accumulation of masses of intracytoplasmic filaments in each case. Of the eleven patients with dysglobulinemia, nine had monoclonal gammopathy and two were found to have polyclonal elevation of gamma globulin levels. Symptoms of neuropathy characteristically preceded detection of serum protein abnormalities by months to years. Nerve fiber lesions involved primarily the axon in four cases; segmental demyelination was the principal abnormality in the other seven. Both abnormalities were present to some degree in all eleven patients. Biphasic myelinopathy with uniform separation of myelin lamellae attributable to globulin deposition was observed in four cases. The microvascular changes included endothelial cytoplasmic enlargement, virtually obliterating the vessel lumen in many instances, with thickening of pericytes, in which intracytoplasmic filaments were prominent and pinocytotic vesicles numerous. No extracellular filaments were noted, and amyloid stains were negative. Possible effects of these microvascular changes include ischemia resulting from severe vascular luminal narrowing, and altered vascular permeability. Severe loss of axons in this group of neuropathies may be the result of ischemia, whereas altered vascular permeability may admit globulin into the endoneurium, where it may directly affect the myelin sheath and precipitate demyelination.

show abstract

mentioning

confidence: 99%

Microangiopathy of vasa nervorum in dysglobulinemic neuropathy

Powell¹,

Rodriguez²,

Hughes³

1984

Annals of Neurology

View full text Add to dashboard Cite

show abstract

“…Our indirect immunofluorescent studies ( Propp et al (1975), showed no such affinity. None of these nerves showed direct immunofluorescent staining (Table 1).…”

Section: Indirect Immunofluorescencementioning

confidence: 58%

“…1). (Propp et al, 1975;Hobbs et al, 1975), and in the endoneurium and perineurium (Chazot et al, 1974(Chazot et al, , 1976 in patients with Waldenstrom's macroglobulinaemia and peripheral neuropathy. In addition, monoclonal IgG and IgA has been found in nerve biopsy samples of patients with myeloma and peripheral neuropathy (Chazot et al.…”

Section: Indirect Immunofluorescencementioning

confidence: 99%

Significance of immunoglobulin deposition in peripheral nerve in neuropathies associated with paraproteinaemia.

Swash¹,

Perrin²,

Schwartz³

1979

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

“…Although the etiology of this type of neuropathy remains unknown, the deposition of antibodies on the myelin sheaths of nerves (2)(3)(4)(5)(6)(7)(8) and the binding of IgM and IgG paraproteins to peripheral nerve myelin (6)(7)(8)(9)(10)(11)(12) suggest that the paraproteins play a causative role in neuropathy. Moreover, IgM paraproteins from some polyneuropathy patients have been found to react with human myelin-associated glycoprotein (MAG) by several groups (13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Polyneuropathy with monoclonal gammopathy: glycolipids are frequently antigens for IgM paraproteins.

Ilyas¹,

Quarles

Dalakas

et al. 1985

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Immunoglobulins from patients with paraproteinemic polyneuropathy were screened for reactivity with nerve and brain glycolipids by ELISA and/or a thin-layerchromatogram-overlay technique. The myelin-associated glycoprotein (MAG) has been shown to be an antigen in many neuropathy patients with IgM gammopathy, but this study focused on seven neuropathy patients in which the IgM paraproteins had been shown not to react with this glycoprotein. Five of these seven had IgM that reacted with components in the acidic glycolipid fraction of human sciatic nerve, and three of these IgMs also reacted with components in the acidic glycolipid fraction of human brain. Little or no reactivity with glycolipids was detected for two patients with neuropathy and IgG gammopathy or for two with neuropathy and IgA gammopathy. The results suggest that neuropathy-patient IgM paraproteins not reactive with MAG often react with acidic glycolipids and thus define a subset of paraproteinemic neuropathies. Since the IgM paraproteins that react with MAG also react with acidic glycolipids of nerve, glycolipid antigens appear to be quite common among the IgM paraproteinemic neuropathies.

show abstract

Waldenstrom's macroglobulinemia and neuropathy

Cited by 102 publications

References 0 publications

Microangiopathy of vasa nervorum in dysglobulinemic neuropathy

Microangiopathy of vasa nervorum in dysglobulinemic neuropathy

Significance of immunoglobulin deposition in peripheral nerve in neuropathies associated with paraproteinaemia.

Polyneuropathy with monoclonal gammopathy: glycolipids are frequently antigens for IgM paraproteins.

Contact Info

Product

Resources

About