Waist-to-hip ratio correlates with homocysteine levels in male patients with coronary artery disease

Lin, Yen‐Hung; Pao, Kuan-Yin; Yang, Wei‐Shiung; Wu, Vin-Cent; Chen, Yu-Jen; Lin, Yu‐Li; Tsai, Wei-Shan; Tsai, I-Jung; Gau, Churn-Shiouh; Hwang, Juey‐Jen

doi:10.1515/cclm.2008.016

Cited by 12 publications

(9 citation statements)

References 42 publications

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“…Considering the association between hyperhomocysteinemia and raised risk of CVD, this observation is consistent with previous reports that WHR is the best predictor of CVD risk, premature death, stroke, non-insulin-dependent diabetes mellitus and female carcinomas [24], while BMI is negatively correlated to cardiovascular disease, premature death, and stroke, but positively to diabetes [25]. Lin et al [26] has shown that in male patients with coronary artery disease homocysteine levels are strongly associated with WHR, but not with BMI. Association between homocysteine and TGA blood levels also indicates a potential impact of homocysteine on CVD risk.…”

Section: Discussionsupporting

confidence: 90%

Homocysteine Levels in Patients with Schizophrenia on Clozapine Monotherapy

Wysokiński

Kłoszewska

2013

Neurochem Res

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We tested the hypothesis that homocysteine levels are higher in blood of schizophrenic subjects on clozapine monotherapy than in healthy controls and they correlate with anthropometric measurements, laboratory tests and results of bioimpedance analysis of body composition. Data for 24 subjects with schizophrenia treated with clozapine and 24 age- and sex-matched healthy volunteers was analyzed. Regarding the whole group, homocysteine levels were significantly higher in men (17.0 ± 3.4 vs. 12.1 ± 4.0 μmol/L, p = 0.009). Homocysteine levels correlated with waist circumference (R = 0.58, p = 0.003), waist-to-hip ratio (R = 0.57, p = 0.003), basal metabolic rate (R = 0.48, p = 0.01), lean body mass [kg] (R = 0.53, p = 0.008), body water [L] (R = 0.53, p = 0.008) and triglycerides (R = 0.57, p = 0.003). There were no significant differences of homocysteine levels for impaired fasting glucose, abdominal obesity, obesity/overweight, and dyslipidemia. Homocysteine levels did not correlate with age, treatment duration, clozapine dose, weight, body mass index, abdominal circumference, blood pressure, total body fat, cholesterol, high density lipoproteins, low density lipoproteins, uric acid, calcium, glucose, insulin, homoeostasis model assessment of insulin resistance 1, and homoeostasis model assessment of insulin resistance 2. We did not find significant differences in blood homocysteine levels between subjects with schizophrenia and controls. Association with waist circumference may support homocysteine role as an important cardiovascular risk factor. Association with lean weight may explain why men have higher levels of homocysteine than women.

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Section: Discussionsupporting

confidence: 90%

Homocysteine Levels in Patients with Schizophrenia on Clozapine Monotherapy

Wysokiński

Kłoszewska

2013

Neurochem Res

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“…Patients with elevated homocysteine levels had significantly lower BMI with no significant correlation between homocysteine level and BMI. The lack of significant association was similar to the findings by some groups,32 although other groups found at least a weak correlation 33,34…”

Section: Discussionsupporting

confidence: 88%

Association between plasma homocysteine and myocardial SPECT abnormalities in patients referred for suspected myocardial ischaemia

Ankrah¹,

Buscombe²,

Sathekge³

2012

CVJA

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BackgroundElevated plasma homocysteine level has emerged as a relatively newly recognised risk factor for coronary artery disease (CAD). However, reduction of plasma homocysteine levels in large prospective studies did not appear to reduce the risk for subsequent cardiac events. In this study, we investigated the association between plasma homocysteine levels and quantitative indices of myocardial perfusion SPECT imaging in patients referred for myocardial ischaemia.MethodsQuantitative myocardial perfusion SPECT indices were obtained for 120 patients who were recruited for the study. All patients underwent a two-day rest–stress myocardial perfusion imaging. Plasma venous sampling was done on all patients after an overnight fast. Of the 120 participants (mean age 56 years, 53% males), 33% had elevated plasma homocysteine levels. The plasma homocysteine level was then compared to the results of imaging and other known risk factors.ResultsAfter adjustment for traditional risk factors of coronary artery disease, patients with elevated homocysteine levels had a significantly higher mean summed stress score (SSS) (11.3 vs 6.9, p = 0.02) than patients with a normal homocysteine level. This was true for both single- and multivessel disease. Also, patients with elevated homocysteine levels had a higher stress end-systolic volume (SESV) (137 vs 105 ml, p = 0.03) and lower post-stress left ventricular ejection fraction (SEF) (54 vs 64%, p = 0.02). The patients with elevated plasma homocysteine levels also had a significantly lower mean body mass index (BMI) (26.6 vs 30.6 kg/m2, p = 0.002). There was a significant relationship between the total number of known risk factors in a patient with CAD and the proportion of patients presenting with elevated plasma homocysteine levels (p = 0.03). Also, the extent of infarct, as measured by the summed rest score (SRS), was more closely correlated with an elevated homocysteine level than with the degree of ischaemia.ConclusionThere was a correlation between plasma homocysteine level and the presence and extent of myocardial perfusion abnormalities in patients with established coronary artery disease, in particular those with multiple risk factors and multi-vessel infarction.

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“…The relationship between the B vitamins and obesity is not clear. A number of studies have found that overweight and obese adults have low blood concentrations of thiamine, vitamins B 6 , B 12 , and folic acid 2,80–88 (Table 4). The B vitamin that is deficient varies among studies.…”

Section: B‐complex Vitamins and Obesitymentioning

confidence: 99%

“…A cross-sectional study reported low blood concentrations of vitamin B6 among obese individuals but adequate concentrations of vitamins B1, B2, B12, and folic acid. 2 Lin et al 81 reported that obese men with coronary artery disease and high homocysteine concentrations had low vitamin B12 and folic acid blood concentrations. In contrast, overweight and obese Thai men and women were found to have low concentrations of folic acid but normal concentrations of B12 compared to normal-weight adults.…”

Section: B-complex Vitamins and Obesitymentioning

confidence: 99%

Impact of micronutrient deficiencies on obesity

2009

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Micronutrient deficiencies have been found in obese individuals across age groups worldwide. While the effects of micronutrient deficiencies on human functions have been studied widely in different populations, there is limited information on how these micronutrient deficiencies affect obese populations. An examination of the available literature suggests associations exist between micronutrient deficiencies and obesity in different populations. These associations and possible mechanisms of the deficiencies' metabolic effects, such as their influence on leptin and insulin metabolism, are discussed here. Further studies are needed to clarify the roles of the different micronutrient deficiencies with respect to obesity and its comorbid conditions.

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Waist-to-hip ratio correlates with homocysteine levels in male patients with coronary artery disease

Abstract: WHR, but not BMI, is a strong independent predictor of plasma tHcy level in male patients with CAD.

Cited by 12 publications

References 42 publications

Homocysteine Levels in Patients with Schizophrenia on Clozapine Monotherapy

Homocysteine Levels in Patients with Schizophrenia on Clozapine Monotherapy

Association between plasma homocysteine and myocardial SPECT abnormalities in patients referred for suspected myocardial ischaemia

Impact of micronutrient deficiencies on obesity

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