Waist to height ratio in nonalcoholic fatty liver disease – Systematic review and meta-analysis

Background Cardiometabolic index (CMI), a novel indicator that combines abdominal obesity and lipid levels, has been confirmed to correlate with non-alcoholic fatty liver disease (NAFLD). However, limited research has been conducted on the relationship between CMI and controlled attenuation parameter (CAP), a parameter measured by transient elastography and reflecting the extent of fat accumulation in the liver. The objective of our study was to investigate the relationship between the two variables. Methods This was a cross-sectional study with a sample size of 1,759 U.S. adults with NAFLD sourced from the NHANES 2017–2020. Participants with a median CAP ≥ 248 dB/m were considered to have hepatic steatosis. CMI was calculated as [waist circumference (cm)/height(cm)]×[TG (mmol/L)/HDL-C (mmol/L)]. Multivariate linear regression, generalized additive model and subgroup analysis were employed to examine the association of CMI and CAP. Results The average age of the 1,759 participants was 50.2 years, with males accounting for 50.76% and females 49.24%. The average BMI was 32.23 kg/m². The multivariate linear regression model indicated that with every 1-unit increase in CMI, there was an associated rise of 10.40 dB/m in CAP (95% CI, 7.14–13.67) after adjusting for covariates and a p for trend < 0.05 suggested the existence of a linear association between the two variables. Similarly, generalized additive model also found it a roughly linear relationship between the two. Subgroup analysis revealed a positive correlation in the majority of subgroups. Conclusions CMI was positively associated with CAP in U.S. adults with NAFLD. Our findings indicated that CMI may serve as an ideal indicator for monitoring the degree of hepatic steatosis among patients with NAFLD.

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Prediction of insulin resistance and non-alcoholic fatty liver disease using serum uric acid and related markers in children and adolescents

Song,

Choi,

Yang

et al. 2024

Preprint

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Objective To investigate the relationship between serum uric acid (Uacid) and related parameters with insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD)and their potential as predictors of IR and NAFLD in children and adolescents Methods The data of 1,648 participants aged 10–18 years was analyzed using nationwide survey. Logistic regression analysis was performed with IR and NAFLD as dependent variables, and odds ratios (ORs) and 95% confidence intervals (CIs) were computed for tertiles 2 and 3 of each parameter in comparison to tertile 1, which served as the reference group. Receiver operating characteristic (ROC) curves were generated to assess predictability of the parameters for IR and NAFLD. Results Hyperuricemia, IR, and NAFLD were significantly associated each other. All Uacid and related markers showed continuous increase in ORs and 95% CIs across the tertiles for IR and NAFLD (all p < 0.001). In ROC curve, all Uacid and related markers demonstrated significant predictability for IR and NAFLD. Overall, Uacid combined with obesity indices showed higher ORs and AUC compared to Uacid alone. Uacid-body mass index (BMI) standard deviation score presented the largest AUC for IR. For NAFLD, Uacid-BMI and Uacid-waist-to-height ratio showed the largest AUC. Conclusions Uacid combined with obesity indices are robust markers for prediction of IR and NAFLD in children and adolescents, which was superior to Uacid. Uacid and related markers have potential as simple markers which does not require fasting for screening of IR and NAFLD in children and adolescents

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Waist to height ratio in nonalcoholic fatty liver disease – Systematic review and meta-analysis

Cited by 3 publications

References 69 publications

Prediction of insulin resistance and elevated liver transaminases using serum uric acid and derived markers in children and adolescents

Prediction of insulin resistance and elevated liver transaminases using serum uric acid and derived markers in children and adolescents

Association between cardiometabolic index and controlled attenuation parameter in U.S. adults with NAFLD: findings from NHANES (2017–2020)

Prediction of insulin resistance and non-alcoholic fatty liver disease using serum uric acid and related markers in children and adolescents

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