Waist circumference predicts increased cardiometabolic risk in normal weight adolescent males

Taylor, Sharonda Alston; Hergenroeder, Albert C.

doi:10.3109/17477166.2011.575149

Cited by 31 publications

(23 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A study among 359,387 European adults showed that the associations of waist circumference with risk of death were stronger among subjects with a lower BMI (4). Similarly, a study among 2,003 adolescents showed that males with a normal BMI and elevated waist circumference were more likely to have elevated levels of cardiovascular risk factors (23). We observed that the associations of higher abdominal fat mass measures with cardiovascular risk factors were stronger among obese children.…”

Section: Interpretation Of Main Findingssupporting

confidence: 48%

BMI, total and abdominal fat distribution, and cardiovascular risk factors in school-age children

Gishti

Gaillard

Durmuş³

et al. 2015

Pediatr Res

View full text Add to dashboard Cite

Background: More specific total body and abdominal fat mass measures might be stronger associated with cardiovascular risk factors in childhood, than BMI. We examined the independent associations of total and abdominal fat measures with cardiovascular risk factors in school age children. Methods:We performed a population-based cohort study among 6,523 children. At the age of 6 y, we measured childhood BMI, and general and abdominal fat mass, using dual-energy X-ray absorptiometry, and ultrasound and cardiovascular risk factors. results: Conditional on BMI, higher fat mass percentage and abdominal fat mass were associated with higher blood pressure, total-and low-density lipoprotein (LDL)-cholesterol, insulin and c-peptide levels, but with lower left ventricular mass and high-density lipoprotein (HDL)-cholesterol (P values < 0.05). These associations differed between underweight, normal weight, overweight, and obese children. Higher childhood adiposity measures were associated with increased odds of cardiovascular risk factors clustering, with the strongest effect for fat mass percentage (odds ratios: 3.01 (95% confidence interval: 2.67, 3.9). conclusion: Our results suggest that general and abdominal fat measures are associated with cardiovascular risk factors in childhood, independent from BMI. These measures may provide additional information for identification of children with an adverse cardiovascular profile.c hildhood obesity is a major public health problem (1). It seems that not only overweight and obesity, but also higher body mass across the full range is associated with risk factors for cardiovascular and metabolic diseases in childhood and adulthood (2-5). BMI does not distinguish lean mass from fat mass (6). Among adults and children, total body fat mass assessed by dual-energy X-ray absorptiometry (DXA) seems to be, independent from BMI, associated with cardiovascular risk factors (3,7). Also, waist circumference, as proxy for abdominal fat mass, was independent of BMI related to the risk of mortality in adults, suggesting that central or abdominal adiposity is more strongly associated with adverse health outcomes (4,8). Abdominal fat mass is an accumulation of both subcutaneous and visceral adipose tissues. In adults, visceral adipose tissue accumulation is stronger related with an adverse glucose and lipid profile than subcutaneous adipose tissue accumulation (8). Thus far, population-based studies focused on the associations of different detailed total body and abdominal fat mass measures with cardiovascular risk factors in children show inconsistent results. Abdominal fat mass in children has been identified as a stronger predictor of cardiovascular risk factors, as compared to BMI, though results are not consistent (2,3,9). These inconsistent findings may be explained by different measures of fat mass and variation of children's age included in these studies.Therefore, we examined in a population-based cohort study among 6,523 school-age children, the independent associations of BMI and total ...

show abstract

Section: Interpretation Of Main Findingssupporting

confidence: 48%

BMI, total and abdominal fat distribution, and cardiovascular risk factors in school-age children

Gishti

Gaillard

Durmuş³

et al. 2015

Pediatr Res

View full text Add to dashboard Cite

show abstract

“…Some authors 38,39 argue that measures of abdominal adiposity might be more useful predictors of cardiometabolic risk in non-obese adolescents, once excess abdominal adiposity could be missed if using a whole body measure such as BMI. There may also exist differences between sexes as Cartier et al 40 highlighted, although in adults, that CRP concentrations seem to be influenced to a greater extent by visceral adiposity in men, as opposed to subcutaneous adiposity in women.…”

Section: Discussionmentioning

confidence: 99%

“…According to Taylor et al, 39 youths have the WC equivalent of adult abdominal obesity at percentiles lower than the frequently used pediatric threshold of 90%. Besides, the WC cut-off values for pediatric ages have to be age and sex specific, so, a fixed cut-off point for WC not taking account of height might underestimate the relative amount of abdominal fat in short subjects and overestimate it in tall subjects.…”

Section: Discussionmentioning

confidence: 99%

Ability of Measures of Adiposity in Identifying Adverse Levels of Inflammatory and Metabolic Markers in Adolescents

et al. 2016

View full text Add to dashboard Cite

Background: Overweight and obesity have been associated with a pro-inflammatory state. We aimed to assess the ability of different measures of overall and abdominal adiposity for identifying adverse levels of inflammatory and metabolic markers in adolescents. Methods: This is a cross-sectional analysis with 529 Portuguese adolescents (267 girls), mean age 14.3 ± 1.7 years. Weight, height, sitting height, waist circumference (WC), and body fat percentage (BF%) were measured; and BMI, waist-to-height ratio (WHtR), and waist-to-sitting-height ratio (WsHtR) were calculated. We measured C-reactive protein (CRP), fibrinogen, erythrocyte sedimentation rate (ESR), complements C3 and C4, leptin, and adiponectin levels. Receiver operating characteristic (ROC) curves were used to estimate the ability of the adiposity measures to discriminate between low/high values of biomarkers. Results: The highest areas under the ROC curves were presented by BF% for fibrinogen and complement C3 in both sexes and for ESR, complement C4, and adiponectin only in girls; by BMI for CRP in girls and for leptin in both sexes; by WHtR for leptin in both sexes and for CRP, fibrinogen, and adiponectin only in girls; by waist circumference for CRP, fibrinogen, and complement C3 only in boys and for complement C4 in girls; and by WsHtR for complement C3 in girls; p < 0.05 for all. Conclusions: The measures that more often presented discriminatory power were, for overall adiposity, BF% in both sexes, and for abdominal adiposity, WHtR in girls and WC in boys. However, small differences in discriminatory capabilities don't allow us to clearly defend the adoption of a single measure above all others.

show abstract

“…Previous studies found that people with abdominal obesity are more likely to have diabetes 21,22 and to be at increased risk for cardiovascular disease. 23,24 Also, as abdominal obesity in midlife may develop an elevated risk of diabetes in older age, it is an important factor in predicting diabetes. 25 It is important to note that abdominal obesity is just one of several factors that are associated with prediabetes.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Prediabetes and Abdominal Obesity Among Healthy-Weight Adults: 18-Year Trend

Mainous

Tanner

et al. 2016

The Annals of Family Medicine

View full text Add to dashboard Cite

PURPOSE Trends in sedentary lifestyle may have influenced adult body composition and metabolic health among individuals at presumably healthy weights. This study examines the nationally representative prevalence of prediabetes and abdominal obesity among healthy-weight adults in 1988 through 2012. METHODSWe analyzed the National Health and Nutrition Examination Survey (NHANES) III (1988III ( -1994 and NHANES for the years 1999 to 2012, focusing on adults aged 20 years and older who have a body mass index (BMI) of 18.5 to 24.99 and do not have diabetes, either diagnosed or undiagnosed. We defined prediabetes using glycated hemoglobin (HbA 1c ) level ranges from 5.7% to 6.4%, as specified by the American Diabetes Association. Abdominal obesity was measured by waist circumference and waist-to-height ratio. RESULTSThe prevalence of prediabetes among healthy-weight adults, aged 20 years and older and without diagnosed or undiagnosed diabetes, increased from 10.2% in 1988-1994 to 18.5% in 2012. Among individuals aged 45 years and older, the prevalence of prediabetes increased from 22.0% to 33.1%. The percentage of adults aged 20 years and older with an unhealthy waist circumference increased from 5.6% in 1988-1994 to 7.6% in 2012. The percentage of individuals with an unhealthy waist-to-height ratio increased from 27.2% in 1988-1994 to 33.7% in 2012. Adjusted models found that measures of abdominal obesity were not independent predictors of prediabetes among adults with a healthy BMI.CONCLUSIONS Among individuals within a healthy BMI range, the prevalence of prediabetes and abdominal obesity has substantially increased. Abdominal obesity does not appear to be the primary cause of the increase.

show abstract

Waist circumference predicts increased cardiometabolic risk in normal weight adolescent males

Abstract: WC within BMI categories may identify those who have cardiometabolic disease risk factors despite having normal or overweight BMI.

Cited by 31 publications

References 22 publications

BMI, total and abdominal fat distribution, and cardiovascular risk factors in school-age children

BMI, total and abdominal fat distribution, and cardiovascular risk factors in school-age children

Ability of Measures of Adiposity in Identifying Adverse Levels of Inflammatory and Metabolic Markers in Adolescents

Prevalence of Prediabetes and Abdominal Obesity Among Healthy-Weight Adults: 18-Year Trend

Contact Info

Product

Resources

About