Waist circumference is associated with pulmonary function in normal-weight, overweight, and obese subjects

Chen, Yue; Rennie, Donna; Cormier, Yvon; Dosman, James A.

doi:10.1093/ajcn/85.1.35

Cited by 214 publications

(183 citation statements)

References 36 publications

(34 reference statements)

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“…These mechanical mechanisms may be more pronounced in people with abdominal than with general obesity. As evidence, reduced pulmonary function has been demonstrated among subjects with large waist circumference irrespective of BMI [9]. Although non-significant, there seemed to be a sex-specific association between waist circumference and incident asthma after adjustment for BMI in our study.…”

Section: Discussioncontrasting

confidence: 50%

“…However, BMI cannot distinguish between fat mass and muscle mass [7]. Most notably, BMI has limitations in predicting abdominal fat deposition, which is associated with reduced pulmonary function, metabolic syndrome and cardiovascular complications [8][9][10]. Abdominal subcutaneous and visceral fat deposits as measured by waist circumference may be metabolically different from other body fat, indicating a separate risk for common medical complications from peripheral fatness measured by BMI [8].…”

mentioning

confidence: 99%

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General and abdominal obesity and incident asthma in adults: the HUNT study

et al. 2012

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Measures of body mass index (BMI) and waist circumference define general obesity and abdominal obesity respectively. While high BMI has been established as a risk factor for asthma in adults, waist circumference has seldom been investigated.To determine the association between BMI, waist circumference and incident asthma in adults, we conducted a prospective study (n523,245) in a population living in Nord-Trøndelag, Norway in 1995 Baseline BMI and waist circumference were measured and categorised as general obesity (BMI o30.0 kg?m 2 ) and abdominal obesity (waist circumference o88 cm in females and o102 cm in males). Incident asthma was self-reported new-onset cases during an 11-yr follow-up period. Odds ratios for asthma associated with obesity were calculated using multivariable logistic regression.General obesity was a risk factor for asthma in females (OR 1.96, 95% CI 1.52-2.52) and males (OR 1.84, 95% CI 1.30-2.59). In females, after additional adjustment for BMI, abdominal obesity remained a risk factor for asthma development (OR 1.46, 95% CI 1.04-2.05). Abdominal obesity seems to increase the risk of incident asthma in females in addition to BMI, indicating that using both measures of BMI and waist circumference in females may be a superior clinical assessment for asthma risk than any measure alone.

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Section: Discussioncontrasting

confidence: 50%

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confidence: 99%

General and abdominal obesity and incident asthma in adults: the HUNT study

et al. 2012

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“…[26][27][28] A consistent negative association between WC and pulmonary function has recently been demonstrated in normal weight, overweight and obese subjects, suggesting that FM stored in the abdominal cavity, particularly visceral fat, most likely directly impedes the descent of the diaphragm leading to primarily restrictive respiration impairment. 28 Among obese subjects, there is evidence of peripheral airway obstruction, as manifested by air trapping and reduced maximum expiratory flow rates. 29,30 Thus, independent of smoking status, excess FM in the abdomen may contribute to airflow limitation.…”

Section: Discussionmentioning

confidence: 73%

Body composition and pulmonary function in the elderly: a 7-year longitudinal study

et al. 2008

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Objective: To evaluate over a 7-year follow-up period the relationships between changes in body composition, fat distribution and pulmonary function in a sample of elderly men and women. Design: Longitudinal clinical study. Subjects: A total of 47 women and 30 men aged 71.6±2.3 and 71.7±2.2 years, respectively, at baseline with body mass index (BMI) values of 24.96 ± 3.28 and 27.04 ± 3.35 kg m À2 were followed for 7 years. Measurements: Body weight, waist circumference, sagittal abdominal diameter (SAD), fat-free mass (FFM) and fat mass as measured by dual energy X-ray absorptiometry (DXA) and forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) by spirometry were evaluated at baseline and after a 7-year mean follow-up. Results: In women as in men there were no significant changes in weight, SAD and BMI. A significant decrease in height and FFM was observed in both women and men. Height-adjusted FEV1 and FVC decreased significantly in women and men over the 7-year follow-up. Changes in SAD were the most powerful predictors of 7-year follow-up of FEV1 and FVC after taking into account, respectively, baseline FEV1 and FVC. Linear regression analysis, performed by using 7-year follow-up lung function variables as dependent variables and changes in body composition variables as independent variables, showed that 1 cm SAD increase predicted a decrease in FEV1 and FVC of 31 and 46 ml, respectively, and 1 kg FFM decrease predicted a decrease in FVC of 38 ml. After subdividing our study population into four categories of change in FFM and SAD, patients with decreased FFM and increased SAD showed the highest probability of having a worsening in FEV1 and FVC. Conclusion: Increase in abdominal fat and FFM decline are significant predictors of lung function decline in the elderly. Old subjects developing both abdominal fat gain and FFM loss show the highest probability of developing worsening in lung function.

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“…Body mass index (BMI) is the most commonly used measure of obesity in population-based studies but the impact of increasing BMI on respiratory function is variable [1][2][3][4][5][6][7]. Other investigations have estimated body fat composition from skin-fold thickness or by bio-electrical impedance, and have demonstrated a negative association with respiratory function [4,7].…”

mentioning

confidence: 99%

The effect of adiposity measured by dual-energy X-ray absorptiometry on lung function

Sutherland

Goulding²,

Grant³

et al. 2008

European Respiratory Journal

100

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Respiratory function is impaired in obesity but there are limitations with body mass index and skin-fold thickness in assessing this effect. The present authors hypothesised that the regional distribution of body fat and lean mass, as measured by dual-energy X-ray absorptiometry (DXA), might be more informative than conventional measurements of total body fat.In total, 107 subjects (55 female, 51.4%) aged 20-50 yrs with no respiratory disease were recruited. Respiratory function tests, anthropometric measurements and a DXA scan were performed. Partial correlation and linear regression analyses were used to explore the effect of adiposity and lean body mass on respiratory function.The majority of respiratory function parameters were significantly correlated with DXA and non-DXA measurements of body fat. Neither thoracic nor abdominal fat had a greater effect. There were some differences in the effect of adiposity between the sexes. Respiratory function was negatively associated with lean body mass in females but positively associated in males. This disappeared after adjustment in females but remained in males.The effects of thoracic and abdominal body fat on respiratory function are comparable but cannot be separated from one another.

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Waist circumference is associated with pulmonary function in normal-weight, overweight, and obese subjects

Cited by 214 publications

References 36 publications

General and abdominal obesity and incident asthma in adults: the HUNT study

General and abdominal obesity and incident asthma in adults: the HUNT study

Body composition and pulmonary function in the elderly: a 7-year longitudinal study

The effect of adiposity measured by dual-energy X-ray absorptiometry on lung function

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