Waist circumference is a better predictor of risk for frailty than BMI in the community-dwelling elderly in Beijing

Liao, Qiuju; Zhang, Zheng; Xiu, Shuangling; Chan, Piu

doi:10.1007/s40520-018-0933-x

Cited by 69 publications

(57 citation statements)

References 42 publications

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“…In the present study, obesity was also associated with a higher risk of frailty before adjusting for WHtR, but it was not associated with the risk of frailty after adjusting for WHtR. Previous epidemiological studies consistently reported that abdominal obesity defined by WC (8,9,16,17,40) and WHtR (21) was associated with a higher prevalence and incidence of frailty in the older adults. Older adults with high WC had high levels of oxidative stress markers, independent of BMI, suggesting a possible involvement of oxidative stress in the genesis of frailty (18,19) .…”

Section: Discussioncontrasting

confidence: 44%

“…Garcia-Esquinas et al (16) reported that obesity was positively associated with the risk of frailty in the older adults, but the association was not significant after adjusting for waist circumference (WC), suggesting that the association between BMI and frailty could be mediated by abdominal obesity. A few previous studies reported that abdominal obesity was associated with higher prevalence and incidence of frailty in the older adults (8,9,16,17) . Increased WC has been suggested to be associated with a marker of oxidative stress and inflammation, independent of BMI (18) , which may be the major mechanism leading to frailty (19) .…”

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confidence: 98%

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Mediating effect of waist:height ratio on the association between BMI and frailty: the Korean Frailty and Aging Cohort Study

et al. 2019

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Body weight is a major risk determinant of frailty, but the effect of obesity on frailty is controversial. The present study aimed to confirm the hypothesis that the risk of frailty is positively associated with obesity (BMI ≥ 30 kg/m2), but the association is mediated by the waist:height ratio (WHtR) in older women and men. A total of 2862 community-dwelling older individuals aged 70–84 years were assessed for frailty using the Korean version of Fatigue, Resistance, Ambulation, Illnesses, and Loss of weight index. Obesity (BMI ≥ 30 kg/m2) was associated with a higher risk of frailty compared with BMI 18·5–<23 kg/m2 in all the older individuals (OR 1·88; 95 % CI 1·11, 3·17; P = 0·018) and in older women (OR 1·86; 95 % CI 1·01, 3·42; P = 0·047) before adjusting for WHtR but was not associated with BMI after adjusting for WHtR. Additionally, obesity was not significantly associated with the risk of frailty before and after adjusting for WHtR in older men. Mediation analysis revealed that the association between BMI and frailty score was mediated by WHtR. Moreover, the mediating effect of WHtR on frailty score was positive in both women and men, but the frailty score was associated with BMI positively in women and negatively in men. The present study suggests that the risk of frailty is higher in obese women, which is mediated by WHtR, but not in obese men.

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Section: Discussioncontrasting

confidence: 44%

mentioning

confidence: 98%

Mediating effect of waist:height ratio on the association between BMI and frailty: the Korean Frailty and Aging Cohort Study

et al. 2019

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“…The prevalence of frailty increased with low BMI. Our ndings corroborate the views that a lower BMI may indicate insu cient reserve capacity and weight loss, which was a key factor in the formation of frailty [44]. Underweight may be due to chronic illness or malnutrition and sarcopenia, which were also associated with increased risk of frailty [45].…”

Section: Discussionsupporting

confidence: 87%

A cross-sectional survey of prevalence and related factors for frail status among middle-aged and elderly people in Chinese communities

Sun

Yang

et al. 2020

Preprint

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Background: With the aggravation of social competition and work burden pressure, the health condition of the middle-aged and above population in China has declined significantly. Frailty can be used as a criterion for evaluating a person's unhealthy state. However, there is limited data on the prevalence and related factors of frail status in Chinese middle-aged and older people.The objective of this study was to explore the correlation between frail status, chronic diseases, abnormal physical examination indicators among middle-aged and older populations.Methods: Participants were 9,985 community-dwelling adults over the age of 40 years living in China. Data were from the 2015 China Health and Retirement Longitudinal Survey which was a nationally representative sample and frailty phenotype was based on Fried frailty criteria. We analyzed the demographics of participants and multivariate-adjusted related factors for frail and pre-frail population.Results: The overall prevalence of frailty and pre-frailty was 3.1% (95% CI: 2.8, 3.5) and 53.66% (95% CI: 52.7, 54.6) among the general Chinese population aged 40 years or older. Hypertension (OR: 1.8, 95% CI: 1.3, 2.593), pain (OR: 1.8, 95% CI: 1.3, 2.5), and hip fracture (OR: 2.2, 95% CI: 1.1, 4.4) were associated with prevalent frailty. Relative factors for frailty also included increased cystatin C (OR: 4.5, 95% CI: 3.0, 6.7) and glycated hemoglobin (OR: 1.2, 95% CI: 1.1, 1.4), as well as decreased peak expiratory flow (OR: 0.993, 95% CI: 0.991, 0.994).Conclusions: Fried-defined frailty and pre-frailty are highly prevalent in the Chinese population over 40 years older. Hypertension, pain, hip fracture, low education, and underweight are major related factors for frailty. The decrease in peak expiratory flow and the increase in cystatin C and glycated hemoglobin are good indicators for detecting frailty. Thus, frailty is an increasingly common condition and will become a major important health issue for people over middle age.

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“…Previous analyses within Nutrition UP 65 had shown that overweight and obesity assessed by BMI were associated with slow GS . However, the BMI can be more prone to errors in the estimation of the body composition of older adults . First, older individuals are generally shorter than younger adults .…”

Section: Discussionmentioning

confidence: 99%

“…16 However, the BMI can be more prone to errors in the estimation of the body composition of older adults. [41][42][43] First, older individuals are generally shorter than younger adults. 42 Second, the amount of muscle mass decreases with age in sarcopenia, and the BMI does not distinguish fat mass from fat-free mass.…”

Section: Discussionmentioning

confidence: 99%

Association of Anthropometric and Nutrition Status Indicators with Hand Grip Strength and Gait Speed in Older Adults

Mendes

Afonso

Moreira

et al. 2018

J Parenter Enteral Nutr

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Waist circumference is a better predictor of risk for frailty than BMI in the community-dwelling elderly in Beijing

Cited by 69 publications

References 42 publications

Mediating effect of waist:height ratio on the association between BMI and frailty: the Korean Frailty and Aging Cohort Study

Mediating effect of waist:height ratio on the association between BMI and frailty: the Korean Frailty and Aging Cohort Study

A cross-sectional survey of prevalence and related factors for frail status among middle-aged and elderly people in Chinese communities

Association of Anthropometric and Nutrition Status Indicators with Hand Grip Strength and Gait Speed in Older Adults

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