Waist circumference correlates with liver fibrosis in children with non-alcoholic steatohepatitis

Manco, Melania; Bedogni, Giorgio; Marcellini, Matilde; Vito, Rita De; Ciampalini, Paolo; Sartorelli, Maria Rita; Comparcola, Donatella; Piemonte, Fiorella; Nobili, Valério

doi:10.1136/gut.2007.142919

Cited by 133 publications

(90 citation statements)

References 55 publications

(49 reference statements)

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“…The prevalence of NAFLD was increased according to the increase of BMI or abdominal circumference reported from Japan 24 . But other report concluded that waist circumference is an independent predictor of advance histological changes in NAFLD than BMI 25,26 . But waist circumference was similar in NASH and NNFL in our series.…”

Section: Discussionmentioning

confidence: 96%

Prevalence and Predictor of Nonalcoholic Steatohepatitis (NASH) in Nonalcoholic Fatty Liver Disease (NAFLD)

Alam¹,

Alam²,

Alam³

et al. 2015

J. Bangladesh Coll. Phys.

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Fatty liver is a common cause of chronic liver disease in developed as well as developing countries.We have designed this study to estimate the prevalence and predictors for non alcoholic steatohepatitis (NASH) in non alcoholic fatty liver disease (NAFLD). We have included 493 patients with sonographic evidence of fatty change in liver and 177 of them had done liver biopsy for histopathological study. Other causes of liver disease and alcohol consumption were excluded. Metabolic syndrome and biochemical and anthropometric evaluation was done.

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Section: Discussionmentioning

confidence: 96%

Prevalence and Predictor of Nonalcoholic Steatohepatitis (NASH) in Nonalcoholic Fatty Liver Disease (NAFLD)

Alam¹,

Alam²,

Alam³

et al. 2015

J. Bangladesh Coll. Phys.

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“…Noteworthy, in children with NAFLD [32], [33] and [34], waist circumference was the only component of the metabolic syndrome associated with liver fibrosis. It is possible that this reflects the lower number of confounding factors in pediatric patients, i.e.…”

Section: Discussionmentioning

confidence: 99%

Risk of nonalcoholic steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease and low visceral adiposity

Fracanzani

Valenti

Bugianesi

et al. 2011

Journal of Hepatology

111

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“…The body mass index (BMI) and BMI Z-score were calculated according to established criteria (18,19). Metabolic syndrome was defined by the presence of three or more of the following five criteria: abdominal obesity (defined by waist circumference ≥90th percentile for age), hypertriglyceridemia (triglycerides >95th percentile for age, gender and race), low HDL cholesterol (HDL cholesterol <5th percentile for age and gender), elevated blood pressure (defined as systolic or diastolic blood pressure >95th percentile for age and gender), and impaired fasting glucose or known type 2 diabetes mellitus.…”

Section: Methodsmentioning

confidence: 99%

Oxidative stress parameters in paediatric non-alcoholic fatty liver disease

Nobili

Parola

Alisi³

et al. 2010

Int J Mol Med

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Abstract.We have investigated the presence and the possible clinical implications of oxidative stress in children with nonalcoholic fatty liver disease (NAFLD). The present study was an observational study of oxidative stress parameters in the progression of paediatric NAFLD. We observed the role of oxidative stress in children diagnosed with NAFLD by evaluating: serum protein carbonyls, hepatic expression of 8-hydroxy-2-deoxyguanosine (8-OHG), and circulating antibody against malondialdehyde adducted human serum albumin (MDA-HSA). Forty consecutive children with biopsy-proven NAFLD (27 male; 13 female) referred to Bambino Gesù Children's Hospital, Rome, Italy, from January 2007 to April 2008 were included in the study. Serum variations of protein carbonyls, 8-OHG, and circulating antibody against MDA-HSA were evaluated. Elevated protein carbonyls were evident in 33 subjects (83%) irrespective of obesity and insulin resistance. Moreover, liver biopsies of NAFLD patients positive for circulating protein carbonyls also showed a significant increase in the nuclear staining for 8-OHG (p=0.006; 95% CI 3.1-17.7). Anti-MDA-HSA IgG above control threshold was detected in 25 (63%) children. Although protein carbonyl levels were unrelated with disease severity, patients with elevated anti-MDA-HSA IgG had scores for lobular inflammation significantly higher (p=0.019) than subjects with antibodies within the control range, while steatosis, hepatocyte ballooning and fibrosis were similar. High anti-MDA-HSA reactivity was also associated with a 13-fold increased risk (OR=12.9; 95% CI 1.5-113.8; p=0.013) of a NAFLD activity score (NAS) ≥5. These results demonstrate that oxidative stress has an high prevalence in children with NAFLD and is associated with an increased severity of steatohepatitis.

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Waist circumference correlates with liver fibrosis in children with non-alcoholic steatohepatitis

Cited by 133 publications

References 55 publications

Prevalence and Predictor of Nonalcoholic Steatohepatitis (NASH) in Nonalcoholic Fatty Liver Disease (NAFLD)

Prevalence and Predictor of Nonalcoholic Steatohepatitis (NASH) in Nonalcoholic Fatty Liver Disease (NAFLD)

Risk of nonalcoholic steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease and low visceral adiposity

Oxidative stress parameters in paediatric non-alcoholic fatty liver disease

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