WAIS factor pattern for neuropsychiatric inpatients

The corpus callosum, with its ∼200 million axons, remains enigmatic in its contribution to cognition and behaviour. Agenesis of the corpus callosum is a congenital condition in which the corpus callosum fails to develop; such individuals exhibit localized deficits in non-literal language comprehension, humour, theory of mind and social reasoning. These findings together with parent reports suggest that behavioural and cognitive impairments in subjects with callosal agenesis may overlap with the profile of autism spectrum disorders, particularly with respect to impairments in social interaction and communication. To provide a comprehensive test of this hypothesis, we directly compared a group of 26 adults with callosal agenesis to a group of 28 adults with a diagnosis of autism spectrum disorder but no neurological abnormality. All participants had full-scale intelligence quotient scores >78 and groups were matched on age, handedness, and gender ratio. Using the Autism Diagnostic Observation Schedule together with current clinical presentation to assess autistic symptomatology, we found that 8/26 (about a third) of agenesis subjects presented with autism. However, more formal diagnosis additionally involving recollective parent-report measures regarding childhood behaviour showed that only 3/22 met complete formal criteria for an autism spectrum disorder (parent reports were unavailable for four subjects). We found no relationship between intelligence quotient and autism symptomatology in callosal agenesis, nor evidence that the presence of any residual corpus callosum differentiated those who exhibited current autism spectrum symptoms from those who did not. Relative to the autism spectrum comparison group, parent ratings of childhood behaviour indicated children with agenesis were less likely to meet diagnostic criteria for autism, even for those who met autism spectrum criteria as adults, and even though there was no group difference in parent report of current behaviours. The findings suggest two broad conclusions. First, they support the hypothesis that congenital disruption of the corpus callosum constitutes a major risk factor for developing autism. Second, they quantify specific features that distinguish autistic behaviour associated with callosal agenesis from autism more generally. Taken together, these two findings also leverage specific questions for future investigation: what are the distal causes (genetic and environmental) determining both callosal agenesis and its autistic features, and what are the proximal mechanisms by which absence of the callosum might generate autistic symptomatology?

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Agenesis of the corpus callosum and autism: a comprehensive comparison

Paul

Corsello

Kennedy

et al. 2014

Brain

110

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Iq Discrepancies Among Impulsive and Non-Impulsive Inmates

Myers

Ellis

1992

soc behav pers

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The intention of this study was to examine the relationship between the right and left hemispheres of the brain and criminal behaviour. It was predicted that prisoners scoring higher on the Verbal scale than the Performance scale of the WAIS-R would tend to commit more analytical thought-out crimes. Those scoring higher on the Performance scale may be more impulsive type criminals and tend to commit crimes less thought out. A total of 51 inmates were tested with the WAIS-R. Inmates who scored lower on the Verbal scale than the Performance scale tended to be more impulsive. Due to the overlap in crimes committed by both types of criminals, it was recommended that future research in this area may include a third category of both impulsive-non-impulsive along with the separation of the two categories.

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WAIS factor pattern for neuropsychiatric inpatients

Cited by 2 publications

References 21 publications

Agenesis of the corpus callosum and autism: a comprehensive comparison

Agenesis of the corpus callosum and autism: a comprehensive comparison

Iq Discrepancies Among Impulsive and Non-Impulsive Inmates

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