Implicit response-effect learning was examined in 2 experiments, using a visual search version of the serial reaction time task introduced by M. J. Nissen and P. Bullemer (1987). In Experiment 1, the relation between the response to the current stimulus and the location of the stimulus on the next trial (i.e., effect) was varied systematically. In Experiment 2, both the frequency of the association between stimuli and responses and the frequency of the association between responses and effects were manipulated. Only the frequency of the response-effect relation influenced learning. These results indicate that response-effect learning is an important component of serial learning. It is argued that response-effect relations constitute the initial implicit component of learning in serial reaction time tasks. From this implicit knowledge, knowledge about the stimulus sequence as well as the response sequence develops later.This research was supported by Grant WIP 014665/W from the German government (program for the integration of scientists from the former East-German Academy of Sciences into German universities). I thank Henry Schroder, Diana Mehnert, and Dorle Henning for their assistance in performing the experiments, Joachim Hoffmann, and especially Peter Frensch for very helpful comments on earlier versions of this article. Moreover, Peter Frensch helped me very much in improving the English writing.