Waddington’s epigenetics or the pictorial meetings of development and genetics

Nicoglou, Antonine

doi:10.1007/s40656-018-0228-8

Cited by 28 publications

(18 citation statements)

References 32 publications

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“…In 1939, the term “epigenetics” was coined by Conrad Hal Waddington (13). Today, one of the most accepted definitions of the term explains that “epigenetics is the study of the heritable changes in gene expression that cannot be explained by alterations in the DNA sequence” (14).…”

Section: An Overview Of Epigeneticsmentioning

confidence: 99%

The Regulatory Roles of Non-coding RNAs in Angiogenesis and Neovascularization From an Epigenetic Perspective

et al. 2019

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Angiogenesis is a crucial process for organ morphogenesis and growth during development, and it is especially relevant during the repair of wounded tissue in adults. It is coordinated by an equilibrium of pro- and anti-angiogenic factors; nevertheless, when affected, it promotes several diseases. Lately, a growing body of evidence is indicating that non-coding RNAs (ncRNAs), such as miRNAs, circRNAs, and lncRNAs, play critical roles in angiogenesis. These ncRNAs can act in cis or trans and alter gene transcription by several mechanisms including epigenetic processes. In the following pages, we will discuss the functions of ncRNAs in the regulation of angiogenesis and neovascularization, both in normal and disease contexts, from an epigenetic perspective. Additionally, we will describe the contribution of Next-Generation Sequencing (NGS) techniques to the discovery and understanding of the role of ncRNAs in angiogenesis.

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Section: An Overview Of Epigeneticsmentioning

confidence: 99%

The Regulatory Roles of Non-coding RNAs in Angiogenesis and Neovascularization From an Epigenetic Perspective

et al. 2019

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“…Epigenetics is defined as the study of heritable changes in gene function without alteration of DNA sequence. 1,2 Epigenetic marks primarily include DNA methylation, histone marks, noncoding RNA (ncRNA), and chromatin remodeling. Many studies have linked epigenetic modifications to both short-term and long-term environmental exposures in plants and animals (recently reviewed in Cavalli and Heard 3 ).…”

Section: Introductionmentioning

confidence: 99%

The Emerging Role of Ten-Eleven Translocation 1 in Epigenetic Responses to Environmental Exposures

Zhu

Brown

2020

Genet Epigenet

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Mounting evidence from epidemiological studies and animal models has linked exposures to environmental factors to changes in epigenetic markers, especially in DNA methylation. These epigenetic changes may lead to dysregulation of molecular processes and functions and mediate the impact of environmental exposures in complex diseases. However, detailed molecular events that result in epigenetic changes following exposures remain unclear. Here, we review the emerging evidence supporting a critical role of ten-eleven translocation 1 (TET1) in mediating these processes. Targeting TET1 and its associated pathways may have therapeutic potential in alleviating negative impacts of environmental exposures, preventing and treating exposure-related diseases.

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“…Despite the diversity of functional molecules in an individual cell type, nearly all cell types in an organism contain the same genetic information or genome. To explain how this diversity of cell types can be achieved from a single cell or zygote, Conrad Waddington proposed the concept of “ epigenesis ” in 1956, where pluripotent cells have the “potential” to generate all other cell types of restricted potential, in which they gradually lose this “potential” during differentiation, famously depicted by the Waddington landscape [1]. This so-called potential was later associated with a physical phenomenon, the methylation of DNA [2], which is a methyl group added to position 5 on the cytosine ring.…”

Section: Introductionmentioning

confidence: 99%

From Genotype to Phenotype: Through Chromatin

Romanowska

Joshi

2019

Genes

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Advances in sequencing technologies have enabled the exploration of the genetic basis for several clinical disorders by allowing identification of causal mutations in rare genetic diseases. Sequencing technology has also facilitated genome-wide association studies to gather single nucleotide polymorphisms in common diseases including cancer and diabetes. Sequencing has therefore become common in the clinic for both prognostics and diagnostics. The success in follow-up steps, i.e., mapping mutations to causal genes and therapeutic targets to further the development of novel therapies, has nevertheless been very limited. This is because most mutations associated with diseases lie in inter-genic regions including the so-called regulatory genome. Additionally, no genetic causes are apparent for many diseases including neurodegenerative disorders. A complementary approach is therefore gaining interest, namely to focus on epigenetic control of the disease to generate more complete functional genomic maps. To this end, several recent studies have generated large-scale epigenetic datasets in a disease context to form a link between genotype and phenotype. We focus DNA methylation and important histone marks, where recent advances have been made thanks to technology improvements, cost effectiveness, and large meta-scale epigenome consortia efforts. We summarize recent studies unravelling the mechanistic understanding of epigenetic processes in disease development and progression. Moreover, we show how methodology advancements enable causal relationships to be established, and we pinpoint the most important issues to be addressed by future research.

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Waddington’s epigenetics or the pictorial meetings of development and genetics

Cited by 28 publications

References 32 publications

The Regulatory Roles of Non-coding RNAs in Angiogenesis and Neovascularization From an Epigenetic Perspective

The Regulatory Roles of Non-coding RNAs in Angiogenesis and Neovascularization From an Epigenetic Perspective

The Emerging Role of Ten-Eleven Translocation 1 in Epigenetic Responses to Environmental Exposures

From Genotype to Phenotype: Through Chromatin

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