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Hassan, Emad Eldin; Gallo, James M.

doi:10.1023/a:1015812615635

Cited by 389 publications

(127 citation statements)

References 7 publications

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“…In particular, MUC5B is likely to play a role in this process because pig gastric mucin, which is often used as model for the MUC5B, has shown strong interaction with cationic macromolecules such as gelatins and chitosan 68 . Besides MUC5B, other salivary proteins such as amylase could also interact with the positively charged droplets, explaining therefore the small difference observed when the two different types of saliva were used.…”

Section: Discussionmentioning

confidence: 99%

Rheological Behavior of Food Emulsions Mixed with Saliva: Effect of Oil Content, Salivary Protein Content, and Saliva Type

et al. 2008

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In this paper, we studied the effect of saliva on the rheological properties of β-lactoglobulin-and lysozyme-stabilized emulsions, prepared at pH=6.7 in relation to variation of emulsions-and saliva-related parameters. The effect of oil-volume fraction (2.5% w/w to 10% w/w), salivary protein concentration (0.1 to 0.8 mg ml −1 ), and the use of both stimulated and unstimulated saliva was investigated. Viscosity and storage modulus were measured before (η emul and G′ emul , respectively) and after addition of saliva (η mix and G′ mix ). To better estimate the changes due to saliva-induced flocculation of the emulsions, the ratios η mix /η emul , G′ mix /G′ emul were calculated. In addition, tan δ (=the ratio of the loss and storage moduli) was investigated to evaluate the viscoelastic behavior of the emulsion/saliva mixtures. Increasing the oil-volume fraction and salivary protein concentration resulted in an increase in η mix /η emul and G′ mix /G′ emul , while a decrease in tan δ of the emulsion/ saliva mixtures is occurring. When compared with unstimulated saliva, mixing β-lactoglobulin-stabilized emulsions with stimulated saliva led to a reduction in η mix / η emul and G′ mix /G′ emul , and an augment of tan δ at all measured deformations. In case of lysozyme-stabilized emulsions, the use of stimulated saliva increased G′ mix / G′ emul for +<3 when compared to unstimulated saliva. The effect of stimulated saliva on the η mix /η emul and tan δ in this mixture is similar to that of unstimulated saliva. These results indicate that the influence of stimulated saliva on the rheological parameters of emulsion/saliva mixtures largely depends on the type of emulsions. To conclude, our findings demonstrate that the rheological behavior of emulsions upon mixing with saliva is greatly affected by both saliva and emulsion properties.

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Section: Discussionmentioning

confidence: 99%

Rheological Behavior of Food Emulsions Mixed with Saliva: Effect of Oil Content, Salivary Protein Content, and Saliva Type

et al. 2008

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“…Essa categoria de métodos é realizada totalmente in vitro e foi proposta primeiramente por Hassan e Gallo [38] . Neste teste, o polímero é previamente misturado com a mucina para realização das medidas reológicas.…”

Section: Métodos Baseados Em Medidas Reológicasunclassified

Plataformas bio(muco)adesivas poliméricas baseadas em nanotecnologia para liberação controlada de fármacos propriedades, metodologias e aplicações

Carvalho¹,

Chorilli²,

Gremião³

2014

Polímeros

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Resumo: Nos últimos tempos, grande destaque tem sido dado no estudo de sistemas bio(muco)adesivos de liberação de fármacos, os quais podem promover um direcionamento e uma retenção mais específica do fármaco incorporado no sistema de liberação, empregando as mais variadas membranas de absorção do organismo. Esta plataforma tecnológica combinada com a nanotecnologia oferece possibilidades como a proteção e o controle da liberação; portanto, são excelentes estratégias para aumentar a biodisponibilidade de fármacos. O objetivo deste trabalho foi estudar as plataformas bio(muco)adesivas poliméricas baseadas em nanotecnologia para liberação controlada de fármacos, enfatizando suas propriedades, metodologias para mensuração e possíveis aplicações para diferentes vias de administração. Palavras-chave: Bio(muco)adesão, bioadesão, sistemas de liberação de fármacos, nanotecnologia, Mecanismos de bio(muco)adesão, medidas de bio(mucoadesão). Nanotechnology-based Polymeric Bio(muco)Adhesive Platforms for Controlling Drug Delivery -properties, Methodologies and ApplicationsAbstract: Studies using bio(muco)adhesive drug delivery systems have recently gained great interest, which can promote drug targeting and more specific contact of the drug delivery system with the various absorptive membranes of the body. This technological platform associated with nanotechnology offers potential for controlling drug delivery; therefore, they are excellent strategies to increase the bioavailability of drugs. The objective of this work was to study nanotechnology-based polymeric bio(muco)adhesive platforms for controlling drug delivery, highlighting their properties, how the bio(muco)adhesion can be measured and their potential applications for different routes of administration.

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“…Some authors investigated the behaviour of mucin/bioadhesive polymer dispersions by rheology 21,22) or by turbidimetric measurements.…”

Section: )mentioning

confidence: 99%

“…Another method was to evaluate the amount of attached or non-adherent nanoparticles after placing on the rat intestinal mucosa. 20) Some authors investigated the behaviour of mucin/bioadhesive polymer dispersions by rheology 21,22) or by turbidimetric measurements. 23) Thus, the interaction between mucin and mucoadhesive products caused changes in the viscosity or turbidity of the dispersions.…”

mentioning

confidence: 99%

Influence of the Homogenisation Procedure on the Physicochemical Properties of PLGA Nanoparticles

Vandervoort

Yoncheva

Ludwig

2004

CHEMICAL & PHARMACEUTICAL BULLETIN

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One of the most popular techniques for the preparation of PLGA nanoparticles is emulsification solvent evaporation and its modifications such as the use of a double emulsion for the encapsulation of water soluble drugs. 1,2) In the current study, a homogenisation step was added to the preparation procedure. The effect of the stirring speed used during emulsification on the PLGA particle properties has been extensively examined.3,4) However, high stirring speed and even sonication are often not sufficient to achieve a small particle size and/or a narrow particle size distribution. Therefore, the high-pressure homogenisation technique was successfully adapted.5) This method is mainly used for the production of microemulsions [6][7][8] and liposomes, 9,10) but there is only a limited number of studies concerning polymeric nanoparticle preparations. 11-13)The particle size is, however, an important parameter codetermining the particle distribution and drug release. More specifically for ophthalmic use, it has been observed that large particles may irritate the eye. Consequently, smaller particles are preferred for ophthalmic delivery systems. 14)Additionally, Calvo et al. have reported that poly(e-caprolactone) nanoparticles (0.20-0.25 mm) improve ocular bioavailibility of indomethacin rather than poly(e-caprolactone) microparticles (6 mm).15) Thus, one of the most important characteristics of nanoparticles is their size.The present study aimed to evaluate the feasibility of homogenisation as a tool to adapt the properties of pilocarpine HCl-loaded PLGA nanoparticles. The influence of the homogenisation procedure on the size, the zeta potential value, drug encapsulation and drug release of the particles prepared was studied.The homogenisation parameters studied were the pressure applied, as well as the number of cycles.PLGA particles were prepared using three different stabilisers: polyvinylalcohol (PVA), carbomer (Carbopol 980 NF) and poloxamer (Lutrol F-68). PVA is the reference stabilising agent for the emulsification-solvent evaporation method.3) The feasibility of the use of Carbopol and poloxamer has been demonstrated in earlier work.16) Apart from these three stabilisers, mixtures of PVA and poloxamer as well as mixtures of PVA and Carbopol were also employed.The ocular bioavailibility can be improved using mucoadhesive particulate drug delivery systems.17) Various methods have been developed to evaluate the mucoadhesion of nanoparticulate drug delivery systems. Determination of the detachment force for microspheres from pig intestinal mucosa 18) or from mucus model gel 19) was proposed. Another method was to evaluate the amount of attached or non-adherent nanoparticles after placing on the rat intestinal mucosa. 20)Some authors investigated the behaviour of mucin/bioadhesive polymer dispersions by rheology 21,22) or by turbidimetric measurements.23) Thus, the interaction between mucin and mucoadhesive products caused changes in the viscosity or turbidity of the dispersions. Since these techniques are easily ...

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Untitled

Cited by 389 publications

References 7 publications

Rheological Behavior of Food Emulsions Mixed with Saliva: Effect of Oil Content, Salivary Protein Content, and Saliva Type

Rheological Behavior of Food Emulsions Mixed with Saliva: Effect of Oil Content, Salivary Protein Content, and Saliva Type

Plataformas bio(muco)adesivas poliméricas baseadas em nanotecnologia para liberação controlada de fármacos propriedades, metodologias e aplicações

Influence of the Homogenisation Procedure on the Physicochemical Properties of PLGA Nanoparticles

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