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Tefera, Solomon; Gilja, Odd Helge; Hatlebakk, Jan Gunnar; Berstad, Arnold

doi:10.1023/a:1005619803917

Cited by 30 publications

(3 citation statements)

References 36 publications

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“…13 Ultrasonography offers a safe, well-tolerated alternative to these methods. Ultrasound examination has been used to assess gastric emptying, gastric volumes, and accommodation in healthy patients, 17–19 as well as in patients with functional dyspepsia, 48 diabetes, 49 gastroesophageal reflux and esophagitis, 50 recurrent abdominal pain, 51 and obesity. 52 Ultrasonography has been shown to yield comparable results to the gold standard tests, 20,21 with antral diameter providing a measure of gastric accommodation and RGV reflecting gastric emptying, and to have good reliability and reproducibility, as well as low interobserver variation and error.…”

Section: Discussionmentioning

confidence: 99%

Effect of Nutritional Rehabilitation on Gastric Motility and Somatization in Adolescents with Anorexia

Pérez

Coley

Crandall

et al. 2013

The Journal of Pediatrics

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Objective To examine gastric function, as well as the presence of somatic complaints, anxiety symptoms, and functional gastrointestinal disorders (FGIDs), in adolescents with anorexia nervosa (AN) before and after nutritional rehabilitation. Study design Sixteen females with AN and 22 healthy controls with similar demographic profiles were included. Gastric emptying (measured as residual gastric volume) and gastric accommodation (measured as postprandial antral diameter) were assessed with abdominal ultrasonography. Participants completed the Children's Somatization Inventory (CSI), the Screen for Child Anxiety-Related Emotional Disorders, and the Questionnaire on Pediatric Gastrointestinal Symptoms–Rome III version. All testing was repeated 3–4 months later. Results Body mass index in the AN group improved over time (P = .012). Fasting gastric parameters were similar in the 2 groups. Maximum postprandial antral diameter was significantly greater in controls compared with the AN group (P = .008). Only adolescents with AN demonstrated a significant increase in maximum postprandial diameter at repeat testing (P = .009). There was no difference in residual gastric volume between the 2 groups. Initial CSI scores were higher in adolescents with AN (P < .0001), including higher scores for nausea and abdominal pain. CSI scores were significantly lower in adolescents with AN (P = .035). Initial scores on the Screen for Child Anxiety-Related Emotional Disorders were significantly higher in adolescents with AN (P = .0005), but did not change over time. Adolescents with AN met significantly more criteria for FGIDs (P = .003). Conclusion Adolescents with AN have impaired gastric accommodation that improves after nutritional rehabilitation, have significantly more somatic complaints, and meet more criteria for anxiety disorders and FGIDs. After nutritional rehabilitation, somatization improves and FGIDs become less common, but symptoms of anxiety persist.

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Section: Discussionmentioning

confidence: 99%

Effect of Nutritional Rehabilitation on Gastric Motility and Somatization in Adolescents with Anorexia

Pérez

Coley

Crandall

et al. 2013

The Journal of Pediatrics

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“…Several studies demonstrated that impaired GA is associated with functional dyspepsia1,8,19 whereas excessive GA is associated with gastroesophageal reflux disease 20. The impaired GA may lead to increased intragastric distribution to the antrum in functional dyspepsia 21.…”

Section: Discussionmentioning

confidence: 99%

The Reproducibility of Tc-Pertechnetate Single Photon Emission Computed Tomography (SPECT) for Measurement of Gastric Accommodation in Healthy Humans: Evaluation of the Test Results Performed at the Same Time and Different Time of the Day

Vasavid

Chaiwatanarata²,

Gonlachanvit³

2010

J Neurogastroenterol Motil

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Background/AimsTechnetium-99m (99mTc)-pertechnetate single photon emission computed tomography (SPECT) allows non-invasive measurement of gastric accommodation (GA) and has been reported to provide the results comparable to the gold standard barostat. The reproducibility of the test when it is performed at different time of the day is not known. The aim of this study was to assess the reproducibility of GA measurement by 99mTc-pertechnetate SPECT at the same and different time of the day.MethodsThree GA studies were performed in each of 20 healthy volunteers (9 males, age 35 ± 9 years), 2 studies in the morning and 1 study in the afternoon. Each study was performed on separate days at least 3 days apart, in random order. The fasting gastric scintigraphy images were acquired using SPECT at 30 minutes after iv 99mTc-pertechnetate. Then, the scintigraphic images were acquired 50 minutes after liquid meal (250 mL, Ensure®) ingestions. Gastric volumes were calculated from transaxial gastric images using Image J software. The GA was defined as the maximum postprandial gastric volume minus fasting gastric volume.ResultsGA measurement by SPECT show good reproducibility at both the same and different time of the day. The intraclass correlation coefficients of GA results for the same time, the first different time and the second different time studies were 0.681, 0.630 and 0.774, respectively, and the intra-subject coefficients of variation were 13.9%, 14.1% and 8.7%, respectively.ConclusionsGA measurement by 99mTc-pertechnetate SPECT shows good reproducibility at both the same and different time of the day. This result suggests that the schedule time does not appear to extremely affect the gastric accommodation value.

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“…Apart from abnormalities in gastric emptying, regional disturbances in gastric motility have also been implicated in the development of GERD, although conflicting results were reported. Most studies have reported either prolonged or abnormally enhanced postprandial gastric relaxation [97,98,99]. Similar to delayed gastric emptying, an abnormal increase in proximal gastric relaxation leads to increased gastric distension and may increase the number of TLESRs.…”

Section: Gastric Dysmotilitymentioning

confidence: 99%

The Spectrum of Motor Function Abnormalities in Gastroesophageal Reflux Disease and Barrett’s Esophagus

et al. 2009

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Barrett’s esophagus has traditionally been regarded as the most severe end of the spectrum of gastroesophageal reflux disease and is of great clinical importance in view of the association with esophageal adenocarcinoma. Studies have documented high levels of esophageal acid exposure in Barrett’s esophagus. Various pathogenetic mechanisms underlie this phenomenon. These include abnormalities in esophageal peristalsis, defective lower esophageal sphincter pressures, gastric dysmotility and bile reflux. Whilst these factors provide evidence for an acquired cause of Barrett’s esophagus, an underlying genetic predisposition cannot be ruled out. Although the past decade has brought about many new discoveries in the pathogenesis of Barrett’s esophagus, it has also added further controversy to this complex disorder. A detailed analysis of the gastrointestinal motor abnormalities occurring in Barrett’s esophagus follows, with a review of the currently available literature and an update on this condition that continues to be of interest to the gastroenterologist.

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Untitled

Cited by 30 publications

References 36 publications

Effect of Nutritional Rehabilitation on Gastric Motility and Somatization in Adolescents with Anorexia

Effect of Nutritional Rehabilitation on Gastric Motility and Somatization in Adolescents with Anorexia

The Reproducibility of Tc-Pertechnetate Single Photon Emission Computed Tomography (SPECT) for Measurement of Gastric Accommodation in Healthy Humans: Evaluation of the Test Results Performed at the Same Time and Different Time of the Day

The Spectrum of Motor Function Abnormalities in Gastroesophageal Reflux Disease and Barrett’s Esophagus

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