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Hanna, W.G.; Moawad, Mona M.

doi:10.1023/a:1012066612090

Cited by 56 publications

(15 citation statements)

References 9 publications

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“…Furthermore, this increases the delocalization of p-electrons over the whole chelating ring and enhances the penetration of the complexes into lipid membranes and the blocking of metal binding sites in the enzymes of microorganisms. Other factors which also increase the activity are the solubility, conductivity, and bond length between the metal and ligand [53][54][55][56]. The bactericidal and fungicidal investigation data of the compounds are summarized in Table 3.…”

Section: Biological Activitymentioning

confidence: 99%

Synthesis, spectroscopic characterization, thermal stability and biological studies of mixed ligand complexes of gemifloxacin drug and 2,2′-bipyridine with some transition metals

2015

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The mixed ligand Zn(II), Zr(IV), Pd(II), Ce(IV), Th(IV), and U(VI) complexes of gemifloxacin and N-donor 2,2 0 -bipyridine have been prepared. These complexes have been characterized by elemental, infrared (IR), ultraviolet-visible (UV-Vis), 1 H nuclear magnetic resonance (NMR), mass spectroscopy, thermal, molar conductance and magnetic susceptibility analyses. The infrared spectra indicate that gemifloxacin acts as a bidentate deprotonated ligand bound to the metal through the pyridone oxygen and one carboxylate oxygen, whereas the 2,2 0 -bipyridine coordinates through the two nitrogen atoms. The central metal in each complex is six-coordinate and a slightly distorted octahedral geometry is proposed. The calculated bond length and force constant, F(U=O), in the uranyl complex are 1.751 Å and 641.04 N m -1 , respectively. The thermodynamic parameters are calculated from the thermal analysis curves using the Coats-Redfern and HorowitzMetzger methods. The antibacterial and antifungal activities of the ligand, metal salt and metal complexes have been tested. The data show that the complexes exhibit significant action against some of the four bacterial species but no effect on two species of fungi compared with gemifloxacin. The antitumor activity of the ligands and their complexes has been evaluated against breast (MCF-7) and colon (HCT-116) cancer cells.

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Section: Biological Activitymentioning

confidence: 99%

Synthesis, spectroscopic characterization, thermal stability and biological studies of mixed ligand complexes of gemifloxacin drug and 2,2′-bipyridine with some transition metals

2015

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“…All Palladium (II) complexes were screened for their antifungal activity against Aspergllus flavus, a common fungicide using cupplate method reported in literature 20 . The solvent used was DMSO.…”

Section: Antifungal Activitymentioning

confidence: 99%

Structural and Anti-Fungal Evaluation of Palladium(II) Complexes Ligated by Triphenyl Phosphine and Isomeric 1-substituted phenyl tetrazoline-5-thione

Pandey¹,

Kumar²,

Shahi³

et al. 2013

Orientjchem.

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A series of phosphine complexes of palladium (II) ligated with 1-substituted phenyl tetrazoline-5-thione have been prepared and identification of complexes are established on the basis of elemental analysis, magnetic susceptibility, conductivity, IR, UV-vis and 1 H NMR spectral data. The phenyl ring was substituted to correlate the electronic effect of such substituents on the magnitude of the anti-fungal activity against Aspergillus favus species.Key words: Palladium (II), Thioamides, antifungal activity, structure and Bonding such substituents on the magnitude of the bioactivities.

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“…The ligand (L), ligand free metal ions and its complexes were evaluated against different species of bacteria and fungi as per the procedure reported earlier [21][22][23][24]. In both, antibacterial and antifungal studies ligand free metal ions in solution show inhibition capacity slightly more than the ligand but much less than complexes against all the species under study.…”

Section: Biological Studymentioning

confidence: 99%

“…Aspergillus-niger and Aspergillus-glaucus fungi were used as the test organism for all the newly synthesized compounds for the purpose of antifungal screening by agar plate technique [23][24]. The results are shown in Graph 1(b).…”

Section: Antifungal Screeningmentioning

confidence: 99%

Synthesis and spectroscopic characterization of transition metal complexes of a 12-membered tetraaza [N4] macrocyclic ligand and their biological activity

Chandra

Gautam

Tyagi

2007

Transition Met Chem

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Cobalt(II), nickel(II) and copper(II) complexes are synthesized with 1,3,7,9-tetraaza-4,6,10,12-tetraphenyl-2,8-dithiacyclododecane, a tetradentate ligand (L) and characterized by elemental analysis, molar conductance measurements, magnetic susceptibitity measurements, mass, i.r., electronic and e.p.r. spectral studies. All the complexes are non-electrolytes so they may be formulated as [M(L)X 2 ] [where, M = Co(II), Ni(II) and Cu(II) and X = Cl ) and NO 3 ) ]. All the complexes are of high spin type. On the basis of i.r., electronic and e.p.r. spectral studies an octahedral geometry has been assigned for Co(II) and Ni(II) complexes and tetragonal geometry for Cu(II) complexes. The antimicrobial activities of the ligand and its complexes, as growth inhibiting agents, have been screened in vitro against two different species of bacteria and plant pathogenic fungi.

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Untitled

Cited by 56 publications

References 9 publications

Synthesis, spectroscopic characterization, thermal stability and biological studies of mixed ligand complexes of gemifloxacin drug and 2,2′-bipyridine with some transition metals

Synthesis, spectroscopic characterization, thermal stability and biological studies of mixed ligand complexes of gemifloxacin drug and 2,2′-bipyridine with some transition metals

Structural and Anti-Fungal Evaluation of Palladium(II) Complexes Ligated by Triphenyl Phosphine and Isomeric 1-substituted phenyl tetrazoline-5-thione

Synthesis and spectroscopic characterization of transition metal complexes of a 12-membered tetraaza [N4] macrocyclic ligand and their biological activity

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