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Design, synthesis, and spectroscopic study of some new flavones containing two azo linkages

“…Flavones can be prepared by different methods such as Baker Venkatraman rearrangement [12], Allan -Robinson [13] and traditional method Claisen -Schmidt condensation reaction followed by oxidative cyclization with DMSO/I 2 [14] CsF with CaO [15] or Oxalic aicd/ethanol [16]. Flavones can react in several ways, including reduction reactions [17], oxidation [18] rearrangement [19], substitution [20] , addition [21], and reaction with organometallic reagents [22].…”

<b>Synthesis of substituted flavone derivatives as potent antimicrobial agents</b>

“…In general, the flavones are synthesized by oxidative cyclization of 2'-hydroxy chalcones [2], by the cyclodehydration of 1-(2-hydroxyphenyl-3-phenyl-1,3-propanedione) [3], by Auwers methods [4] and via intermolecular Witting reaction [5]. It has been observed that the substitution five or six member heterocyclic group in C-2 position instead of phenyl group improves the biological activity of flavones [6][7][8]. In view of these report, we extended our earlier work to synthesize new substituted flavone derivative as potent antimicrobial agent.…”

Microwave‐Induced, Iodine‐Alumina Catalyzed Transformations of 1‐(2′‐hydroxyaryl)‐3‐(2‐chloroquinolin‐3‐yl)‐prop‐2‐en‐1‐one

“…It has been observed that the substitution of five or six member heterocyclic group in C-2 position instead of phenyl group improves the biological activity of flavones [7][8][9] . Similarly, microwave (MW) irradiation is an efficient and environmentally-benign method to activate various organic transformations to afford products in higher yields in shorter reaction periods.…”