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Triwitayakorn, Anusorn; Suwajanakorn, Somchai; Pruksananonda, Kamthorn; Sereepapong, Wisan; Ahnonkitpanit, Vichuda

doi:10.1023/a:1022977002954

Cited by 51 publications

(17 citation statements)

References 25 publications

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“…However, the rate of in vivo– matured oocytes positively correlates with dominant follicle size (dominant follicle ≤10 mm, 6.9%; 10 to 14 mm, 10.6%; >14 mm, 15.1%) ( 233 ). Similarly, Triwitayakorn et al ( 238 ) observed that oocyte recovery rate increased from 57% of follicles <10 mm to 80% of follicles 10 to 14 mm and further to 86% of follicles >14 mm on the day of oocyte retrieval.…”

Section: Endocrine Requirements For Oocyte Maturation and Ovulationmentioning

confidence: 85%

Novel Concepts for Inducing Final Oocyte Maturation in In Vitro Fertilization Treatment

2018

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Infertility affects one in six of the population and increasingly couples require treatment with assisted reproductive techniques. In vitro fertilization (IVF) treatment is most commonly conducted using exogenous FSH to induce follicular growth and human chorionic gonadotropin (hCG) to induce final oocyte maturation. However, hCG may cause the potentially life-threatening iatrogenic complication “ovarian hyperstimulation syndrome” (OHSS), which can cause considerable morbidity and, rarely, even mortality in otherwise healthy women. The use of GnRH agonists (GnRHas) has been pioneered during the last two decades to provide a safer option to induce final oocyte maturation. More recently, the neuropeptide kisspeptin, a hypothalamic regulator of GnRH release, has been investigated as a novel inductor of oocyte maturation. The hormonal stimulus used to induce oocyte maturation has a major impact on the success (retrieval of oocytes and chance of implantation) and safety (risk of OHSS) of IVF treatment. This review aims to appraise experimental and clinical data of hormonal approaches used to induce final oocyte maturation by hCG, GnRHa, both GnRHa and hCG administered in combination, recombinant LH, or kisspeptin. We also examine evidence for the timing of administration of the inductor of final oocyte maturation in relationship to parameters of follicular growth and the subsequent interval to oocyte retrieval. In summary, we review data on the efficacy and safety of the major hormonal approaches used to induce final oocyte maturation in clinical practice, as well as some novel approaches that may offer fresh alternatives in future.

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Section: Endocrine Requirements For Oocyte Maturation and Ovulationmentioning

confidence: 85%

Novel Concepts for Inducing Final Oocyte Maturation in In Vitro Fertilization Treatment

2018

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“…However, the rate of in vivo matured oocytes positively correlated with follicle size (dominant follicle ≤10 mm 6.9%, 10–14 mm 10.6%, >14 mm 15.1%) ( 36 ). Finally, Triwitayakorn et al observed that oocyte recovery rate increased from 57% of follicles < 10 mm to 80% of follicles 10–14 mm and further to 86% of follicles > 14 mm on the day of oocyte retrieval ( 37 ).…”

Section: Discussionmentioning

confidence: 99%

Follicle Size on Day of Trigger Most Likely to Yield a Mature Oocyte

Abbara

Vuong

et al. 2018

Front. Endocrinol.

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ObjectiveTo identify follicle sizes on the day of trigger most likely to yield a mature oocyte following hCG, GnRH agonist (GnRHa), or kisspeptin during IVF treatment.DesignRetrospective analysis to determine the size of follicles on day of trigger contributing most to the number of mature oocytes retrieved using generalized linear regression and random forest models applied to data from IVF cycles (2014–2017) in which either hCG, GnRHa, or kisspeptin trigger was used.SettingHCG and GnRHa data were collected at My Duc Hospital, Ho Chi Minh City, Vietnam, and kisspeptin data were collected at Hammersmith Hospital, London, UK.PatientsFour hundred and forty nine women aged 18–38 years with antral follicle counts 4–87 were triggered with hCG (n = 161), GnRHa (n = 165), or kisspeptin (n = 173).Main outcome measureFollicle sizes on the day of trigger most likely to yield a mature oocyte.ResultsFollicles 12–19 mm on the day of trigger contributed the most to the number of oocytes and mature oocytes retrieved. Comparing the tertile of patients with the highest proportion of follicles on the day of trigger 12–19 mm, with the tertile of patients with the lowest proportion within this size range, revealed increases of 4.7 mature oocytes for hCG (P < 0.0001) and 4.9 mature oocytes for GnRHa triggering (P < 0.01). Using simulated follicle size profiles of patients with 20 follicles on the day of trigger, our model predicts that the number of oocytes retrieved would increase from a mean 9.8 (95% prediction limit 9.3–10.3) to 14.8 (95% prediction limit 13.3–16.3) oocytes due to the difference in follicle size profile alone.ConclusionFollicles 12–19 mm on the morning of trigger administration were most likely to yield a mature oocyte following hCG, GnRHa, or kisspeptin.

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“… Increasing n.e. Triwitayakorn 2003 [ 14 ] P 35.9 Long short Only ICSI 991 10-14 Always increasing together with oocyte recovery rate None n.e. none Rosen 2008 [ 19 ] P 34.1 Long shortantag IVF/ICSI 2934 10-13-16-19 IVF: n.e.…”

Section: Methodsmentioning

confidence: 99%

A critical review of bi-dimensional and three-dimensional ultrasound techniques to monitor follicle growth: do they help improving IVF outcome?

Revelli¹,

Martiny²,

Piane³

et al. 2014

Reprod Biol Endocrinol

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BackgroundThis review focuses on the possibility of improving the outcome of human IVF by studying the follicles where oocytes grow by ultrasound techniques. A comprehensive analysis of bi-dimensional (2D) and three-dimensional (3D) ultrasound (US) assessment of the follicle size and volume is presented.MethodsPublished reports from the year 1999 to 2014 analyzing the relationship between oocyte competence, IVF outcome and ultrasound assessment of the follicle size and volume have been critically analyzed.ResultsUS assessment of growing follicles has been performed mainly by 2D-US, and while overall very useful, it has been found to be of limited usefulness in predicting oocyte competence, recognize which follicles will release a mature metaphase II oocytes and decide the ideal time to trigger ovulation. In fact, a quite wide follicle size range (16–22 mm) has been reported to be associated with mature oocytes with good competence toward fertilization and embryo development. It has been also shown that smaller follicles sometimes contain mature, fertilizable oocytes. However, embryos derived from smaller follicles have probably a lower implantation potential, while follicles larger than 22 mm often contain post-mature eggs.ConclusionsThe study of follicular size by 2D-US is of limited usefulness in helping in the identification of follicles containing the best oocytes and in choosing the best moment to trigger ovulation. Possibly the value of US in this area will be improved by large prospective studies in which automated 3D-US will be used.

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Abstract: Collection of oocytes from small follicles, especially with a mean diameter less than 10 mm, and in vitro maturation of immature oocytes before fertilization may allow the total number of good quality and transferable embryos to be increased.

Cited by 51 publications

References 25 publications

Novel Concepts for Inducing Final Oocyte Maturation in In Vitro Fertilization Treatment

Novel Concepts for Inducing Final Oocyte Maturation in In Vitro Fertilization Treatment

Follicle Size on Day of Trigger Most Likely to Yield a Mature Oocyte

A critical review of bi-dimensional and three-dimensional ultrasound techniques to monitor follicle growth: do they help improving IVF outcome?

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